Method for preparing 3-trifluoromethyl chalcones

ABSTRACT

Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M 1  is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula 2 comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula 5 wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula 6 wherein Y is OR 11  or NR 12 R 13 , and R 11 , R 12  and R 13  are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula 7 wherein Q and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.

FIELD OF THE INVENTION

This invention pertains to a method for preparing 3-trifluoromethylchalcones and trifluoroacetyl intermediates. The present invention alsorelates to novel trifluoroacetyl and halo compounds useful as startingmaterials and intermediates for the aforedescribed method.

SUMMARY OF THE INVENTION

The present invention provides a method for preparing a compound ofFormula 1

wherein

-   -   Z is optionally substituted phenyl; and    -   Q is phenyl or 1-naphthalenyl, each optionally substituted;        comprising distilling water from a mixture comprising a compound        of Formula 2

a compound of Formula 3

a base comprising at least one compound selected from the groupconsisting of

-   -   alkaline earth metal hydroxides of Formula 4

M(OH)₂   4

-   -   -   wherein M is Ca, Sr or Ba,

    -   alkali metal carbonates of Formula 4a

(M¹)₂CO₃   4a

wherein M¹ is Li, Na or K,

-   -   1,5-diazabicyclo[4.3.0]non-5-ene and        1,8-diazabicyclo[5.4.0]undec-7-ene,        and an aprotic solvent capable of forming a low-boiling        azeotrope with water.

This invention also provides a method for preparing a compound ofFormula 2 wherein Z is optionally substituted phenyl, comprising

-   (1) forming a reaction mixture comprising a Grignard reagent derived    from a compound of Formula 5

Z X   5

-   wherein X is Cl, Br or I,-   by contacting the compound of Formula 5 with-   (a) magnesium metal, or-   (b) an alkylmagnesium halide-   in the presence of an ethereal solvent; and then-   (2) contacting the reaction mixture with a compound of Formula 6

-   wherein    -   Y is OR¹¹ or NR¹²R¹³;    -   R¹¹ is C₁-C₅ alkyl; and    -   R¹² and R¹³ are independently C₁-C₂ alkyl; or R¹² and R¹³ are        taken together as —CH₂CH₂OCH₂CH₂—.

This invention also provides a method for preparing a compound ofFormula 2 wherein Z is phenyl optionally substituted with up to 5substituents independently selected from R²; and each R² isindependently F, Cl, Br, C₁-C₆ alkyl, C₁-C₆ fluoroalkyl, C₁-C₆ alkoxy,C₁-C₆ fluoroalkoxy, C₁-C₆ alkylthio or C₁-C₆ fluoroalkylthio, comprising

-   (1) forming a reaction mixture comprising a Grignard reagent derived    from a compound of Formula 5

Z—X   5

-   wherein X is I,-   by contacting the compound of Formula 5 with-   (a) magnesium metal, or-   (b) an alkylmagnesium halide-   in the presence of an ethereal solvent; and then-   (2) contacting the reaction mixture with a compound of Formula 6

-   wherein    -   Y is OR¹¹ or NR¹²R¹³;    -   R11 ^(is) C₁-C₅ alkyl; and    -   R¹² and R¹³ are independently C₁-C₂ alkyl; or R¹² and R¹³ are        taken together as —CH₂CH₂OCH₂CH₂—.

This invention also relates to the method disclosed above for preparinga compound of Formula 1 from a compound of Formula 2 and a compound ofFormula 3 wherein the method is further characterized by preparing thecompound of Formula 2 from the compounds of Formulae 5 and 6 by themethod disclosed above.

The invention also relates to a method for preparing a compound ofFormula 7

wherein

-   -   Z is optionally substituted phenyl; and    -   Q is phenyl or 1-naphthalenyl, each optionally substituted;        using a compound of Formula 1. The method is characterized        by (a) preparing the compound of Formula 1 by the method        disclosed above, or (b) using as said compound of Formula 1 a        compound of Formula 1 prepared by the method disclosed above.

The present invention also relates to novel compounds of Formulae 2 and5, useful as starting materials for the aforedescribed methods.

DETAILS OF THE INVENTION

As used herein, the terms “comprises,” “comprising,” “includes,”“including,” “has,” “having,” “contains” or “containing,” or any othervariation thereof, are intended to cover a non-exclusive inclusion. Forexample, a composition, a mixture, process, method, article, orapparatus that comprises a list of elements is not necessarily limitedto only those elements but may include other elements not expresslylisted or inherent to such composition, mixture, process, method,article, or apparatus. Further, unless expressly stated to the contrary,“or” refers to an inclusive or and not to an exclusive or. For example,a condition A or B is satisfied by any one of the following: A is true(or present) and B is false (or not present), A is false (or notpresent) and B is true (or present), and both A and B are true (orpresent).

Also, the indefinite articles “a” and “an” preceding an element orcomponent of the invention are intended to be nonrestrictive regardingthe number of instances (i.e. occurrences) of the element or component.Therefore “a” or “an” should be read to include one or at least one, andthe singular word form of the element or component also includes theplural unless the number is obviously meant to be singular.

In the above recitations, the term “alkyl”, used either alone or incompound words such as “alkylthio” or “haloalkyl” includes straightchain or branched alkyl, such as, methyl, ethyl, n-propyl, i-propyl, orthe different butyl, pentyl or hexyl isomers.

“Alkoxy” includes, for example, methoxy, ethoxy, n-propyloxy,isopropyloxy and the different butoxy, pentoxy and hexyloxy isomers.“Alkylthio” includes branched or straight-chain alkylthio moieties suchas methylthio, ethylthio, and the different propylthio, butylthio,pentylthio and hexylthio isomers. “Alkylsulfinyl” includes bothenantiomers of an alkylsulfinyl group. Examples of “alkylsulfinyl”include CH₃S(O)—, CH₃CH₂S(O)—, CH₃CH₂CH₂S(O)—, (CH₃)₂CHS(O)— and thedifferent butylsulfinyl, pentylsulfinyl and hexylsulfinyl isomers.Examples of “alkylsulfonyl” include CH₃S(O)₂—, CH₃CH₂S(O)₂—,CH₃CH₂CH₂S(O)₂—, (CH₃)₂CHS(O)₂—, and the different butylsulfonyl,pentylsulfonyl and hexylsulfonyl isomers. “Alkylamino”, “dialkylamino”and the like, are defined analogously to the above examples.

“Cycloalkyl” includes, for example, cyclopropyl, cyclobutyl, cyclopentyland cyclohexyl. The term “alkylcycloalkyl” denotes alkyl substitution ona cycloalkyl moiety and includes, for example, ethylcyclopropyl,i-propylcyclobutyl, 3-methylcyclopentyl and 4-methylcyclohexyl. The term“cycloalkylalkyl” denotes cycloalkyl substitution on an alkyl moiety.Examples of “cycloalkylalkyl” include cyclopropylmethyl,cyclopentylethyl, and other cycloalkyl moieties bonded to straight-chainor branched alkyl groups.

The term “halogen”, either alone or in compound words such as“haloalkyl”, or when used in descriptions such as “alkyl substitutedwith halogen” includes fluorine, chlorine, bromine or iodine. Further,when used in compound words such as “haloalkyl”, or when used indescriptions such as “alkyl substituted with halogen” said alkyl may bepartially or fully substituted with halogen atoms which may be the sameor different. Similarly, “fluoroalkyl” means said alkyl may be partiallyor fully substituted with fluorine atoms. Examples of “haloalkyl” or“alkyl substituted with halogen” include F₃C—, C1CH₂—, CF₃CH₂— andCF₃CCl₂—. The terms “halocycloalkyl”, “haloalkoxy”, “haloalkylthio”,“haloalkylsulfinyl”, “haloalkylsulfonyl”, and the like, are definedanalogously to the term “haloalkyl”. Examples of “haloalkoxy” includeCF₃O—, CCl₃CH₂O—, HCF₂CH₂CH₂O— and CF₃CH₂O—. Examples of “haloalkylthio”include CCl₃S—, CF₃S—, CCl₃CH₂S— and C1CH₂CH₂CH₂S—. Examples of“haloalkylsulfinyl” include CF₃S(O)—, CCl₃S(O)—, CF₃CH₂S(O)— andCF₃CF₂S(O)—. Examples of “haloalkylsulfonyl” include CF₃S(O)₂—,CCl₃S(O)₂—, CF₃CH₂S(O)₂— and CF₃CF₂S(O)₂—. The term “halodialkylamino”denotes dialkylamino wherein at least one of the amino components issubstituted with at least one halogen. Examples of “halodialkylamino”include CH₂C1CH₂N(CH₃)— and (CF₃CH₂)₂N—.

“Alkylcarbonyl” denotes a straight-chain or branched alkyl moietiesbonded to a C(═O) moiety. Examples of “alkylcarbonyl” include CH₃C(═O)—,CH₃CH₂CH₂C(═O)— and (CH₃)₂CHC(═O)—. Examples of “alkoxycarbonyl” includeCH₃OC(═O)—, CH₃CH₂OC(═O)—, CH₃CH₂CH₂OC(═O)—, (CH₃)₂CHOC(═O)— and thedifferent butoxy or pentoxycarbonyl isomers.

In the present disclosure and claims, the radicals “SO₂” and S(O)₂” meansulfonyl, “—CN” means cyano, “—NO₂” means nitro, and “—OH” meanshydroxy.

The total number of carbon atoms in a substituent group is indicated bythe “C_(i)-C_(j)” prefix where i and j are numbers from 1 to 9. Forexample, C₁-C₄ alkylsulfonyl designates methylsulfonyl throughbutylsulfonyl, including possible isomers. C₂ alkoxycarbonyl designatesCH₃OC(O)—; C₃ alkoxycarbonyl designates CH₃CH₂C(O)—; and C₄alkoxycarbonyl includes (CH₃)₂CHC(O)— and CH₃CH₂CH₂C(O)—.

When a compound is substituted with a substituent bearing a subscriptthat indicates the number of said substituents can exceed 1, saidsubstituents (when they exceed 1) are independently selected from thegroup of defined substituents, e.g., for (R^(v))_(r) in U-1 of Exhibit1, r is 1, 2, 3, 4 or 5. When a group contains a substituent which canbe hydrogen (e.g., —NR⁴R⁵ in the definition of R³ wherein R⁴ or R⁵ maybe hydrogen in Embodiment 2), then when this substituent is taken ashydrogen, it is recognized that this is equivalent to said group beingunsubstituted. When a variable group is shown to be optionally attachedto a position, for example (R^(v))_(r) in U-41 of Exhibit 1 wherein rmay be 0, then hydrogen may be at the position even if not recited inthe variable group definition. When one or more positions on a group aresaid to be “not substituted” or “unsubstituted”, then hydrogen atoms areattached to take up any free valency.

The terms “heterocyclic ring” or “heterocycle” denote a ring or ring inwhich at least one atom forming the ring backbone is not carbon, e.g.,nitrogen, oxygen or sulfur. Typically a heterocyclic ring contains nomore than 4 nitrogens, no more than 2 oxygens and no more than 2sulfurs. The term “ring member” refers to an atom or other moiety (e.g.,C(═O), C(═S), S(O) or S(O)₂) forming the backbone of a ring. Unlessotherwise indicated, a heterocyclic ring can be a saturated, partiallyunsaturated or fully unsaturated ring, and furthermore, an unsaturatedheterocyclic ring can be partially unsaturated or fully unsaturated.Therefore recitation of “heterocyclic ring” without indicating whetherit is saturated or unsaturated is synonymous with recitation of“saturated or unsaturated heterocyclic ring”. When a fully unsaturatedheterocyclic ring satisfies Hückel's rule, then said ring is also calleda “heteroaromatic ring” or “aromatic heterocyclic ring”. “Aromatic”indicates that each of the ring atoms is essentially in the same planeand has a p-orbital perpendicular to the ring plane, and that (4n+2) πelectrons, where n is a positive integer, are associated with the ringto comply with Hückel's rule. Unless otherwise indicated, heterocyclicrings and ring systems can be attached through any available carbon ornitrogen by replacement of a hydrogen on said carbon or nitrogen.

The term “optionally substituted” in connection with phenyl or1-naphthalenyl in the definitions of Z and Q refers to groups which areunsubstituted or have at least one non-hydrogen substituent. As Z and Qare peripheral to the portions of the molecules undergoing reaction inthe present methods, a very broad range of both number and type ofsubstituents is compatible with the present methods. As used herein, thefollowing definitions shall apply unless otherwise indicated. The term“optionally substituted” is used interchangeably with the phrase“substituted or unsubstituted” or with the term “(un)substituted.”Unless otherwise indicated, an optionally substituted group may have asubstituent at each substitutable position of the group, and eachsubstitution is independent of the other.

When R³ or Q¹ is a 5- or 6-membered nitrogen-containing heterocyclicring, it may be attached to the remainder of Formula 1 though anyavailable carbon or nitrogen ring atom, unless otherwise described. Asnoted in Embodiment 1B, R³ or Q¹ can be (among others) phenyl optionallysubstituted with one or more substituents selected from a group ofsubstituents as defined in Embodiment 1B. An example of phenyloptionally substituted with one to five substituents is the ringillustrated as U-1 in Exhibit 1, wherein R^(v) is as defined inEmbodiment 1B for R³ or Q¹ and r is an integer from 0 to 5. As notedabove, R³ or Q¹ can be (among others) 5- or 6-membered heterocyclicring, which may be saturated or unsaturated, optionally substituted withone or more substituents selected from a group of substituents asdefined in Embodiment 2. Examples of a 5- or 6-membered unsaturatedaromatic heterocyclic ring optionally substituted with from one or moresubstituents include the rings U-2 through U-61 illustrated in Exhibit 1wherein R^(v) is any substituent as defined in Embodiment 2 for R³ or Q¹and r is an integer from 0 to 4, limited by the number of availablepositions on each U group. As U-29, U-30, U-36, U-37, U-38, U-39, U-40,U-41, U-42 and U-43 have only one available position, for these U groupsr is limited to the integers 0 or 1, and r being 0 means that the Ugroup is unsubstituted and a hydrogen is present at the positionindicated by (R^(v))_(r).

Exhibit 1

Note that when R³ or Q¹ is a 5- or 6-membered saturated or unsaturatednon-aromatic heterocyclic ring optionally substituted with one or moresubstituents selected from the group of substituents as defined inEmbodiment 2 for R³ or Q¹, one or two carbon ring members of theheterocycle can optionally be in the oxidized form of a carbonyl moiety.

Examples of a 5- or 6-membered saturated or non-aromatic unsaturatedheterocyclic ring include the rings G-1 through G-35 as illustrated inExhibit 2. Note that when the attachment point on the G group isillustrated as floating, the G group can be attached to the remainder ofFormula 1 through any available carbon or nitrogen of the G group byreplacement of a hydrogen atom. The optional substituents correspondingto R^(v) can be attached to any available carbon or nitrogen byreplacing a hydrogen atom. For these G rings, r is typically an integerfrom 0 to 4, limited by the number of available positions on each Ggroup.

Note that when R³ or Q¹ comprises a ring selected from G-28 throughG-35, G² is selected from O, S or N. Note that when G² is N, thenitrogen atom can complete its valence by substitution with either H orthe substituents corresponding to R^(v) as defined in Embodiment 1B.

Exhibit 2

Note that when R^(v) is H when attached to an atom, this is the same asif said atom is unsubstituted. The nitrogen atoms that requiresubstitution to fill their valence are substituted with H or R^(v). Notethat when the attachment point between (R^(v))_(r) and the U group isillustrated as floating, (R^(v))_(r) can be attached to any availablecarbon atom or nitrogen atom of the U group. Note that when theattachment point on the U group is illustrated as floating, the U groupcan be attached to the remainder of Formula 1 through any availablecarbon or nitrogen of the U group by replacement of a hydrogen atom.Note that some U groups can only be substituted with less than 4 R^(v)groups (e.g., U-2 through U-5, U-7 through U-48, and U-52 through U-61).

A wide variety of synthetic methods are known in the art to enablepreparation of aromatic and nonaromatic heterocyclic rings; forextensive reviews see the eight volume set of Comprehensive HeterocyclicChemistry, A. R. Katritzky and C. W. Rees editors-in-chief, PergamonPress, Oxford, 1984 and the twelve volume set of ComprehensiveHeterocyclic Chemistry II, A. R. Katritzky, C. W. Rees and E. F. V.Scriven editors-in-chief, Pergamon Press, Oxford, 1996.

In some instances herein ratios are recited as single numbers, which arerelative to the number 1; for example, a ratio of 4 means 4:1.

In the context of the present invention, “decanter” refers to a devicecapable of separately removing an upper (i.e. less dense) liquid phaseand/or a lower (i.e. more dense) liquid phase from a liquid (e.g.,azeotrope condensate) comprising two liquid phases. A Dean-Stark trap isan example of one type of decanter.

Embodiments of the present invention include:

-   -   Embodiment 1. The method described in the Summary of the        Invention for preparing the compound of Formula 1 comprising        distilling water from the mixture comprising the compound of        Formula 2, the compound of Formula 3, the base, and the aprotic        solvent capable of forming a low-boiling azeotrope with water.    -   Embodiment 1A. The method of Embodiment 1 wherein the base is an        alkaline earth metal hydroxide of Formula 4 and the mixture        further comprises a polar aprotic solvent.    -   Embodiment 1B. The method of Embodiment 1 wherein the base        comprises an alkali metal carbonate of Formula 4a.    -   Embodiment 1C. The method of Embodiment 1 wherein the base        comprises 1,5-diazabicyclo[4.3.0]non-5-ene,        1,8-diazabicyclo[5.4.0]undec-7-ene or a mixture thereof.    -   Embodiment 1D. The method described in the Summary of the        Invention for preparing a compound of Formula 7 using a compound        of Formula 1, the method characterized by preparing the compound        of Formula 1 by the method of Embodiment 1.    -   Embodiment 1E. The method described in the Summary of the        Invention for preparing a compound of Formula 7 using a compound        of Formula 1, the method characterized by preparing the compound        of Formula 1 by the method of Embodiment 1A.    -   Embodiment 1F. The method described in the Summary of the        Invention for preparing a compound of Formula 7 using a compound        of Formula 1, the method characterized by preparing the compound        of Formula 1 by the method of Embodiment 1B.    -   Embodiment 1G. The method described in the Summary of the        Invention for preparing a compound of Formula 7 using a compound        of Formula 1, the method characterized by preparing the compound        of Formula 1 by the method of Embodiment 1C.    -   Embodiment 2. The method of any one of Embodiments 1 through 1G        wherein        -   Q is phenyl or 1-naphthalenyl, each optionally substituted            with up to four substituents independently selected from R³;        -   each R³ is independently halogen, C₁-C₆ alkyl, C₁-C₆            haloalkyl, C₂-C₆ alkenyl, C₂-C₆ haloalkenyl, C₂-C₆ alkynyl,            C₃-C₆ haloalkynyl, C₃-C₆ cycloalkyl, C₃-C₆ halocycloalkyl,            C₁-C₆ alkoxy, C₁-C₆ haloalkoxy, C₁-C₆ alkylthio, C₂-C₇            alkylcarbonyl, C₂-C₇ haloalkylcarbonyl, C₁-C₆ haloalkylthio,            C₁-C₆ alkylsulfinyl, C₁-C₆ haloalkylsulfinyl, C₁-C₆            alkylsulfonyl, C₁-C₆ haloalkylsulfonyl, —N(R⁴)R⁵,            —C(═W)N(R⁴)R⁵, —C(═W)OR⁵, —CN, —OR¹¹ or —NO₂; or a phenyl            ring or a 5- or 6-membered saturated or unsaturated            heterocyclic ring, each ring optionally substituted with one            or more substituents independently selected from halogen,            C₁-C₆ alkyl, C₁-C₆ haloalkyl, C₃-C₆ cycloalkyl, C₃-C₆            halocycloalkyl, C₁-C₆ alkoxy, C₁-C₆ haloalkoxy, C₁-C₆            alkylthio, C₁-C₆ haloalkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆            haloalkylsulfinyl, C₁-C₆ alkylsulfonyl, C₁-C₆            haloalkylsulfonyl, —CN, —NO₂, —N(R⁴)R⁵, —C(═W)N(R⁴)R⁵,            —C(═O)OR⁵ and R⁷;        -   each R⁴ is independently H, C₁-C₆ alkyl, C₂-C₆ alkenyl,            C₂-C₆ alkynyl, C₃-C₆ cycloalkyl, C₄-C₇ alkylcycloalkyl,            C₄-C₇ cycloalkylalkyl, C₂-C₇ alkylcarbonyl or C₂-C₇            alkoxycarbonyl;        -   each R⁵ is independently H; or C₁-C₆ alkyl, C₂-C₆ alkenyl,            C₂-C₆ alkynyl, C₃-C₆ cycloalkyl, C₄-C₇ alkylcycloalkyl or            C₄-C₇ cycloalkylalkyl, each optionally substituted with one            or more substituents independently selected from R⁶;        -   each R⁶ is independently halogen, C₁-C₆ alkyl, C₁-C₆ alkoxy,            C₁-C₆ alkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆ alkylsulfonyl,            C₁-C₆ alkylamino, C₂-C₈ dialkylamino, C₃-C₆ cycloalkylamino,            C₂-C₇ alkylcarbonyl, C₂-C₇ alkoxycarbonyl, C₂-C₇            alkylaminocarbonyl, C₃-C₉ dialkylaminocarbonyl, C₂-C₇            haloalkylcarbonyl, C₂-C₇ haloalkoxycarbonyl, C₂-C₇            haloalkylaminocarbonyl, C₃-C₉ halodialkylaminocarbonyl, —OH,            —NH₂, —CN or —NO₂; or Q¹;        -   each R⁷ is independently a phenyl ring or a pyridinyl ring,            each ring optionally substituted with one or more            substituents independently selected from R⁸;        -   each R⁸ is independently halogen, C₁-C₆ alkyl, C₁-C₆            haloalkyl, C₁-C₆ alkoxy, C₁-C₆ haloalkoxy, C₁-C₆ alkylthio,            C₁-C₆ haloalkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆            haloalkylsulfinyl, C₁-C₆ alkylsulfonyl, C₁-C₆            haloalkylsulfonyl, C₁-C₆ alkylamino, C₂-C₆ dialkylamino,            C₂-C₄ alkylcarbonyl, C₂-C₄ alkoxycarbonyl, C₂-C₇            alkylaminocarbonyl, C₃-C₇ dialkylaminocarbonyl, —OH, —NH₂,            —C(═O)OH, —CN or —NO₂;        -   each Q¹ is independently a phenyl ring or a 5- or 6-membered            saturated or unsaturated heterocyclic ring, each ring            optionally substituted with one or more substituents            independently selected from halogen, C₁-C₆ alkyl, C₁-C₆            haloalkyl, C₃-C₆ cycloalkyl, C₃-C₆ halocycloalkyl, C₁-C₆            alkoxy, C₁-C₆ haloalkoxy, C₁-C₆ alkylthio, C₁-C₆            haloalkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆ haloalkylsulfinyl,            C₁-C₆ alkylsulfonyl, C₁-C₆ haloalkylsulfonyl, C₁-C₆            alkylamino, C₂-C₆ dialkylamino, —CN, —NO₂, —C(═W)N(R⁹)R¹⁰            and —C(═O)OR¹⁰;        -   each R⁹ is independently H, C₁-C₆ alkyl, C₁-C₆ haloalkyl,            C₂-C₆ alkenyl, C₂-C₆ alkynyl, C₃-C₆ cycloalkyl, C₄-C₇            alkylcycloalkyl, C₄-C₇ cycloalkylalkyl, C₂-C₇ alkylcarbonyl            or C₂-C₇ alkoxycarbonyl;        -   each R¹⁰ is independently H; or C₁-C₆ alkyl, C₁-C₆            haloalkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, C₃-C₆ cycloalkyl,            C₄-C₇ alkylcycloalkyl or C₄-C₇ cycloalkylalkyl;        -   each R¹¹ is independently H; or C₂-C₆ alkenyl, C₂-C₆            alkynyl, C₃-C₆ cycloalkyl, C₄-C₇ alkylcycloalkyl, C₄-C₇            cycloalkylalkyl, C₂-C₇ alkylcarbonyl, C₂-C₇ alkoxycarbonyl,            C₁-C₆ alkylsulfonyl or C₁-C₆ haloalkylsulfonyl; and        -   each W is independently O or S.    -   Embodiment 2A. The method of Embodiment 2 wherein Q is phenyl        optionally substituted with up to four substituents        independently selected from R³.    -   Embodiment 2B. The method of Embodiment 2 wherein Q is        1-naphthalenyl optionally substituted with up to four        substituents independently selected from R³.    -   Embodiment 2C. The method of Embodiment 2 wherein each R³ is        independently halogen, C₁-C₆ alkyl, C₁-C₆ haloalkyl,        —C(W)N(R⁴)R⁵, —C(W)OR⁵ or —CN; or a phenyl ring or a 5- or        6-membered saturated or unsaturated heterocyclic ring, each ring        optionally substituted with substituents independently selected        from halogen, C₁-C₆ alkyl, C₁-C₆ haloalkyl, —CN, —C(W)N(R⁴)R⁵        and —C(O)OR⁵.    -   Embodiment 2D. The method of Embodiment 2 wherein each R⁴ is        independently H or C₁-C₆ alkyl.    -   Embodiment 2E. The method of Embodiment 2 wherein each R⁵ is        independently H; or C₁-C₆ alkyl optionally substituted with        substituents independently selected from R⁶.    -   Embodiment 2F. The method of Embodiment 2 wherein each R⁶ is        independently halogen, C₁-C₆ alkyl, C₁-C₆ alkoxy, C₁-C₆        alkylthio, C₂-C₇ alkoxycarbonyl, C₂-C₇ alkylaminocarbonyl, C₃-C₉        dialkylaminocarbonyl, C₂-C₇ haloalkylaminocarbonyl, C₃-C₉        halodialkylaminocarbonyl or —CN; or Q¹.    -   Embodiment 2G. The method of Embodiment 2 wherein each Q¹ is        independently a pyridinyl ring optionally substituted with up to        four halogen.    -   Embodiment 2H. The method of Embodiment 2B wherein        -   Q is

and

-   -   -   R³ is C(O)N(R⁴)R⁵ or C(O)OR⁵.

    -   Embodiment 2I. The method of Embodiment 2H wherein        -   R⁴ is H, C₂-C₇ alkylcarbonyl or C₂-C₇ alkoxycarbonyl.

    -   Embodiment 2J. The method of Embodiment 2I wherein R⁴ is H.

    -   Embodiment 2K. The method of any one of Embodiments 2H through        2J wherein        -   R³ is C(O)N(R⁴)R⁵ or C(O)OR^(5a);        -   R⁵ is C₁-C₆ alkyl or C₁-C₆ haloalkyl, each substituted with            one substituent independently selected from hydroxy, C₁-C₆            alkoxy, C₁-C₆ alkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆            alkylsulfonyl, C₂-C₇ alkylaminocarbonyl, C₃-C₉            dialkylaminocarbonyl, C₂-C₇ haloalkylaminocarbonyl and C₃-C₉            halodialkylaminocarbonyl; and        -   R^(5a) is C₁-C₆ alkyl, C₂-C₆ alkenyl or C₂-C₆ alkynyl, each            optionally substituted with one or more substituents            independently selected from halogen, C₁-C₂ alkoxy and phenyl            optionally substituted with up to 5 substituents selected            from halogen and C₁-C₃ alkyl.

    -   Embodiment 2L. The method of any one of Embodiments 2H through        2K wherein        -   R^(5a) is C₁-C₆ alkyl optionally substituted with phenyl.

    -   Embodiment 2M. The method of any one of Embodiments 2H through        2L wherein        -   R³ is C(O)N(R⁴)R⁵.

    -   Embodiment 2N. The method of any one of Embodiments 2H through        2J wherein        -   R³ is C(O)OR⁵.

    -   Embodiment 2O. The method of any one of Embodiments 2K through        2L wherein        -   R³ is C(O)OR^(5a).

    -   Embodiment 3. The method of any one of Embodiments 1 through 2O        wherein        -   Z is phenyl optionally substituted with up to 5 substituents            independently selected from R² (i.e.

wherein n is 0, 1, 2, 3, 4 or 5); and

-   -   -   each R² is independently halogen, C₁-C₆ alkyl, C₁-C₆            haloalkyl, C₁-C₆ alkoxy, C₁-C₆ haloalkoxy, C₁-C₆ alkylthio,            C₁-C₆ haloalkylthio, C₁-C₆ alkylamino, C₂-C₆ dialkylamino,            —CN or —NO₂.

    -   Embodiment 3A. The method of Embodiment 3 wherein Z is a phenyl        ring substituted with up to 3 substituents independently        selected from R², said substituents attached at the 3, 4 or 5        positions of the phenyl ring.

    -   Embodiment 3B. The method of Embodiment 3 or 3A wherein each R²        is independently F, Cl, Br, C₁-C₆ alkyl, C₁-C₆ fluoroalkyl,        C₁-C₆ alkoxy, C₁-C₆ fluoroalkoxy, C₁-C₆ alkylthio or C₁-C₆        fluoroalkylthio.

    -   Embodiment 3C. The method of Embodiment 3 or 3A wherein each R²        is independently halogen, C₁-C₆ alkyl, C₁-C₆ haloalkyl or —CN.

    -   Embodiment 3D. The method of Embodiment 3C wherein each R² is        independently halogen or C₁-C₆ haloalkyl.

    -   Embodiment 3E. The method of Embodiment 3D wherein each R² is        independently halogen or CF₃.

    -   Embodiment 3F. The method of Embodiment 3E wherein each R² is        independently F, Cl or CF₃.

Embodiment 3G. The method of Embodiment 3A wherein Z is

-   -   -   R^(2a) is halogen, C₁-C₂ haloalkyl or C₁-C₂ haloalkoxy;            R^(2b) is H, halogen or cyano; and R^(2c) is H, halogen or            CF₃.

    -   Embodiment 3H. The method of Embodiment 3G wherein R^(2a) is CF₃        or halogen; and R^(2c) is H, CF₃ or halogen.

    -   Embodiment 3I. The method of Embodiment 3H wherein R^(2a) is        CF₃.

    -   Embodiment 3J. The method of any one of Embodiments 3G through        3I wherein R^(2b) is H.

    -   Embodiment 3K. The method of any one of Embodiments 3G through        3J wherein R^(2c) is CF₃ or halogen.

    -   Embodiment 3L. The method of Embodiment 3K wherein R^(2c) is        CF₃, F, Cl or Br.

    -   Embodiment 3M. The method of Embodiment 3L wherein R^(2c) is F,        Cl or Br.

    -   Embodiment 3N. The method of Embodiment 3L wherein R^(2c) is        CF₃, Cl or Br.

    -   Embodiment 3O. The method of Embodiment 3N wherein R^(2c) is Cl        or Br.

    -   Embodiment 3P. The method of Embodiment 3O wherein R^(2b) is H        and R^(2c) is Cl.

    -   Embodiment 3Q. The method of Embodiment 3O wherein R^(2b) is H        and R^(2c) is Br.

    -   Embodiment 4. The method described in the Summary of the        Invention for preparing a compound of Formula 2, comprising (1)        forming a reaction mixture comprising a Grignard reagent derived        from a compound of Formula 5 by contacting the compound of        Formula 5 with (a) magnesium metal, or (b) an alkylmagnesium        halide in the presence of an ethereal solvent; and then (2)        contacting the reaction mixture with a compound of Formula 6.

    -   Embodiment 4A. The method of any one of Embodiments 1 through 2O        and 3 through 3Q further characterized by preparing the compound        of Formula 2 by the method of Embodiment 4.

    -   Embodiment 4B. The method of Embodiment 4 or 4A wherein X is Cl        or I.

    -   Embodiment 4C. The method of Embodiment 4 or 4A wherein X is Br        or I.

    -   Embodiment 4D. The method of Embodiment 4 or 4A wherein X is Cl        or Br.

    -   Embodiment 4E. The method of Embodiment 4 or 4A wherein X is Cl.

    -   Embodiment 4F. The method of Embodiment 4 or 4A wherein X is Br.

    -   Embodiment 4G. The method of Embodiment 4 or 4A wherein X is I.

    -   Embodiment 4H. The method of any one of Embodiments 4 through 4G        wherein        -   Z is phenyl optionally substituted with up to 5 substituents            independently selected from R² (i.e.

wherein n is 0, 1, 2, 3, 4 or 5); and

-   -   -   each R² is independently F, Cl, Br, C₁-C₆ alkyl, C₁-C₆            fluoroalkyl, C₁-C₆ alkoxy, C₁-C₆ fluoroalkoxy, C₁-C₆            alkylthio or C₁-C₆ fluoroalkylthio;        -   provided that when X is Cl then each R² is independently F,            Cl, C₁-C₆ alkyl, C₁-C₆ fluoroalkyl, C₁-C₆ alkoxy, C₁-C₆            fluoroalkoxy, C₁-C₆ alkylthio or C₁-C₆ fluoroalkylthio.

    -   Embodiment 4I. The method of Embodiment 4H wherein when X is Br        then each R² is independently F, Cl, C₁-C₆ alkyl, C₁-C₆        fluoroalkyl, C₁-C₆ alkoxy, C₁-C₆ fluoroalkoxy, C₁-C₆ alkylthio        or C₁-C₆ fluoroalkylthio; and when X is Cl then each R² is        independently F, C₁-C₆ alkyl, C₁-C₆ fluoroalkyl, C₁-C₆ alkoxy,        C₁-C₆ fluoroalkoxy, C₁-C₆ alkylthio or C₁-C₆ fluoroalkylthio.

    -   Embodiment 4J. The method of any one of Embodiments 3, 4H and 4I        wherein Z is a phenyl ring substituted with up to 3 substituents        independently selected from R², said substituents attached at        the 3, 4 or 5 positions of the phenyl ring.

    -   Embodiment 4K. The method of any one of Embodiments 4H, 4I and        4J wherein each R² is independently F, Cl, Br, C₁-C₆ alkyl or        C₁-C₆ fluoroalkyl.

    -   Embodiment 4L. The method of Embodiment 4K wherein each R² is        independently F, Cl, Br or C₁-C₆ fluoroalkyl.

    -   Embodiment 4M. The method of Embodiment 4L wherein each R² is        independently F, Cl, Br or CF₃.

    -   Embodiment 4N. The method of any one of Embodiments 4H through        4M wherein Z is a phenyl ring substituted with 2 substituents        independently selected from R², said substituents attached at        the 3 and 5 positions of the phenyl ring.

    -   Embodiment 4O. The method of Embodiment 4N wherein each R² is        independently F, Cl, Br or CF₃.

    -   Embodiment 4P. The method of Embodiment 4O wherein at least one        R² is CF₃.

    -   Embodiment 4Q. The method of Embodiment 4P wherein one R² is CF₃        and the other R² is Cl or Br.

    -   Embodiment 4R. The method of Embodiment 4Q wherein one R² is CF₃        and the other R² is Cl.

    -   Embodiment 4S. The method of Embodiment 3A or 3H wherein Z is

R^(2a) is F, Cl, Br, C₁-C₂ fluoroalkyl or C₁-C₂ fluoroalkoxy; R^(2b) isH, F, Cl or Br; and

-   -   -   -   R^(2c) is H, F, Cl, Br or CF₃.

    -   Embodiment 4T. The method of Embodiment 4S wherein R^(2a) is        CF₃, F, Cl or Br; and        -   R^(2c) is H, CF₃, F, Cl or Br.

    -   Embodiment 4U. The method of Embodiment 4T wherein R^(2a) is        CF₃.

    -   Embodiment 4V. The method of any one of Embodiments 4S through        4U wherein R^(2b) is H.

    -   Embodiment 4W. The method of any one of Embodiments 4S through        4V wherein R^(2c) is CF₃, F, Cl or Br.

    -   Embodiment 4X. The method of Embodiment 4W wherein R^(2c) is F,        Cl or Br.

    -   Embodiment 4Y. The method of Embodiment 4W wherein R^(2a) is        CF₃, Cl or Br.

    -   Embodiment 4Z. The method of Embodiment 4Y wherein R^(2c) is Cl        or Br.

    -   Embodiment 4ZA. The method of Embodiment 4Z wherein R^(2b) is H        and R^(2c) is Cl.

    -   Embodiment 4ZB. The method of Embodiment 4Z wherein R^(2b) is H        and R^(2c) is Br.

    -   Embodiment 4ZC. The method of any one of Embodiments 4S through        4ZB wherein X is I.

    -   Embodiment 5. A compound of Formula 2 as described in the        Summary of the Invention wherein        -   Z is

-   -   -   R^(2a) is CF₃; R^(2b) is H or halogen; and R^(2c) is            halogen.

    -   Embodiment 5A. A compound of Embodiment 5 wherein R^(2b) is H.

    -   Embodiment 5B. A compound of Embodiment 5 or 5A wherein R^(2c)        is F, Cl or Br.

    -   Embodiment 5C. A compound of Embodiment 5B wherein R^(2c) is Cl        or Br.

    -   Embodiment 5D. A compound of Embodiment 5C selected from the        group consisting of:        -   1-[3-chloro-5-(trifluoromethyl)]-2,2,2-trifluoroethanone;            and        -   1-[3-bromo-5-(trifluoromethyl)]-2,2,2-trifluoroethanone.

    -   Embodiment 5E. A compound of Formula 5 as described in the        Summary of the Invention which is        1-chloro-3-iodo-5-(trifluoromethyl)benzene.

    -   Embodiment 6. The method of Embodiment 1A or 1E wherein M is Ca        (i.e. the alkaline earth metal hydroxide is calcium hydroxide).

    -   Embodiment 6A. The method of Embodiment 1A, 1E or 6 wherein the        molar ratio of the alkaline earth metal hydroxide to the        compound of Formula 2 is at least about 0.1.

    -   Embodiment 6A1. The method of Embodiment 6A wherein the molar        ratio of the alkaline earth metal hydroxide to the compound of        Formula 2 is at least about 0.5.

    -   Embodiment 6B. The method of Embodiment 6A1 wherein the molar        ratio of the alkaline earth metal hydroxide to the compound of        Formula 2 is at least about 0.8.

    -   Embodiment 6C. The method of any one of Embodiments 1A, 1E or 6        through 6B wherein the molar ratio of the alkaline earth metal        hydroxide to the compound of Formula 2 is no more than about 1.

    -   Embodiment 6D. The method of Embodiment 1B or 1F wherein M¹ is K        (i.e. the alkali metal carbonate is potassium carbonate).

    -   Embodiment 6E. The method of Embodiment 1B, 1F or 6D wherein the        molar ratio of the alkali metal carbonate to the compound of        Formula 2 is at least about 0.01.

    -   Embodiment 6F. The method of Embodiment 6E wherein the molar        ratio of the alkali metal carbonate to the compound of Formula 2        is at least about 0.03.

    -   Embodiment 6G. The method of any one of Embodiments 1B, 1F or 6D        through 6F wherein the molar ratio of the alkali metal carbonate        to the compound of Formula 2 is no more than about 0.2.

    -   Embodiment 6H. The method of Embodiment 1C or 1G wherein the        molar ratio of the 1,5-diazabicyclo[4.3.0]non-5-ene,        1,8-diazabicyclo[5.4.0]undec-7-ene or a mixture thereof to the        compound of Formula 2 is at least about 0.01.

    -   Embodiment 6I. The method of Embodiment 6H wherein the molar        ratio of the 1,5-diazabicyclo[4.3.0]non-5-ene,        1,8-diazabicyclo[5.4.0]undec-7-ene or a mixture thereof to the        compound of Formula 2 is at least about 0.03.

    -   Embodiment 6J. The method of any one of Embodiments 1C, 1G, 6H        or 6I wherein the molar ratio of the        1,5-diazabicyclo[4.3.0]non-5-ene,        1,8-diazabicyclo-[5.4.0]undec-7-ene or a mixture thereof to the        compound of Formula 2 is no more than about 0.2.

    -   Embodiment 7. The method of Embodiment 1A or 1E wherein the        polar aprotic solvent comprises an amide or sulfoxide (including        mixtures thereof).

    -   Embodiment 7A. The method of Embodiment 7 wherein the polar        aprotic solvent comprises one or more of N,N-dimethylformamide,        N,N-dimethylacetamide, N-methylpyrrolidinone and methyl        sulfoxide.

    -   Embodiment 7B. The method of Embodiment 7 wherein the polar        aprotic solvent comprises an amide.

    -   Embodiment 7C. The method of Embodiment 7B wherein the polar        aprotic solvent comprises one or more of N,N-dimethylformamide,        N,N-dimethylacetamide, N-methylpyrrolidinone.

    -   Embodiment 7D. The method of Embodiment 7C wherein the polar        aprotic solvent comprises N,N-dimethylformamide.

    -   Embodiment 8. The method of Embodiment 1A or 1E wherein the        aprotic solvent capable of forming a low-boiling azeotrope with        water comprises an ether.

    -   Embodiment 8A. The method of Embodiment 8 wherein the aprotic        solvent capable of forming a low-boiling azeotrope with water        comprises tert-butyl methyl ether.

    -   Embodiment 8B. The method of any one of Embodiments 1B, 1C, 1F,        1G or 6D through 6J wherein the aprotic solvent capable of        forming a low-boiling azeotrope with water comprises        acetonitrile.

    -   Embodiment 8C. The method of Embodiment 8A wherein the polar        aprotic solvent comprises N,N-dimethylformamide.

    -   Embodiment 8D. The method of Embodiment 8C wherein the        tert-butyl methyl ether and the N,N-dimethylformamide are in a        weight ratio in a range from about 0.5 to about 2.

    -   Embodiment 9. The method of Embodiment 1A or 1E wherein the        mixture is at a temperature of at least about 65° C.

    -   Embodiment 9A. The method of Embodiment 9 wherein the mixture is        at a temperature of at least about 70° C.

    -   Embodiment 9B. The method of Embodiment 9A wherein the mixture        is at a temperature of at least about 75° C.

    -   Embodiment 9C. The method of Embodiment 1B, 1C, 1F or 1G wherein        the mixture is at a temperature of at least about 65° C.

    -   Embodiment 9D. The method of Embodiment 9C wherein the mixture        is at a temperature of at least about 80° C.

    -   Embodiment 9E. The method of Embodiment 9D wherein the mixture        is at a temperature of at least about 85° C.

    -   Embodiment 9F. The method of any one of Embodiments 9 through 9E        wherein the mixture is at a temperature of no more than about        110° C.

    -   Embodiment 9G. The method of Embodiment 9F wherein the mixture        is at a temperature of no more than about 100° C.

    -   Embodiment 9H. The method of Embodiment 9G wherein the mixture        is at a temperature of no more than about 90° C.

    -   Embodiment 10. The method of Embodiment 4 or 4A wherein the        compound of Formula 5 is contacted with magnesium metal.

    -   Embodiment 10A. The method of Embodiment 10 wherein the molar        ratio of magnesium metal to the compound of Formula 5 is at        least about 1.

    -   Embodiment 10B. The method of Embodiment 10A wherein the molar        ratio of magnesium metal to the compound of Formula 5 is at        least about 1.02.

    -   Embodiment 10C. The method of Embodiment 10B wherein the molar        ratio of magnesium metal to the compound of Formula 5 is at        least about 1.05.

    -   Embodiment 10D. The method of any one of Embodiments 10 through        10C wherein the molar ratio of magnesium metal to the compound        of Formula 5 is no more than about 1.2.

    -   Embodiment 10E. The method of Embodiment 10D wherein the molar        ratio of magnesium metal to the compound of Formula 5 is no more        than about 1.1.

    -   Embodiment 10F. The method of Embodiment 4 or 4A wherein the        compound of Formula 5 is contacted with an alkylmagnesium        halide.

    -   Embodiment 10G. The method of Embodiment 10F wherein the        alkylmagnesium halide is a C₁-C₄ alkylmagnesium halide.

    -   Embodiment 10H. The method of Embodiment 10F or 10G wherein the        alkylmagnesium halide is a secondary alkylmagnesium halide.

    -   Embodiment 10I. The method of Embodiment 10H wherein the        alkylmagnesium halide is an isopropylmagnesium halide.

    -   Embodiment 10J. The method of Embodiment 10I wherein the        alkylmagnesium halide is isopropylmagnesium chloride.

    -   Embodiment 10K. The method of any one of Embodiments 10F through        10J wherein the molar ratio of the alkylmagnesium halide to the        compound of Formula 5 is at least about 1.

    -   Embodiment 10L. The method of Embodiment 10K wherein the molar        ratio of the alkylmagnesium halide to the compound of Formula 5        is at least about 1.05.

    -   Embodiment 10M. The method of any one of Embodiments 10F through        10L wherein the molar ratio of the alkylmagnesium halide to the        compound of Formula 5 is no more than about 1.2.

    -   Embodiment 10N. The method of Embodiment 10M wherein the molar        ratio of the alkylmagnesium halide to the compound of Formula 5        is no more than about 1.15.

    -   Embodiment 10O. The method of Embodiment 4 or 4A wherein the        compound of Formula 6 is methyl trifluoroacetate or ethyl        trifluoroacetate.

    -   Embodiment 11. The method of Embodiment 4 or 4A wherein the        ethereal solvent comprises one or more of ethyl ether,        1,4-dioxane, tetrahydrofuran and 1,2-dimethoxyethane.

    -   Embodiment 11A. The method of Embodiment 11 wherein the ethereal        solvent comprises ethyl ether or tetrahydrofuran.

    -   Embodiment 11B. The method of Embodiment 11A wherein the        ethereal solvent comprises tetrahydrofuran.

    -   Embodiment 11C. The method of any one of Embodiments 4, 4A or 11        through 11B wherein the compound of Formula 5 is contacted        with (a) magnesium metal, or (b) an alkylmagnesium halide in the        presence of an aromatic hydrocarbon solvent in addition to the        ethereal solvent.

    -   Embodiment 11D. The method of Embodiment 11C wherein the        aromatic hydrocarbon solvent comprises one or more of benzene,        toluene and xylene.

    -   Embodiment 11E. The method of Embodiment 11D wherein the        aromatic hydrocarbon solvent comprises toluene.

Embodiments of this invention, including Embodiments 1-11E above as wellas any other embodiments described herein, can be combined in anymanner, and the descriptions of variables in the embodiments pertain notonly to the aforedescribed methods for preparing compounds of Formulae1, 2 and 7 but also to the starting compounds and intermediate compoundsuseful for preparing the compounds of Formulae 1, 2 and 7 by thesemethods.

Combinations of Embodiments 1-11E are illustrated by:

-   -   Embodiment A. The method described in the Summary of the        Invention for preparing the compound of Formula 1 comprising        distilling water from the mixture comprising the compound of        Formula 2, the compound of Formula 3, the base, and the aprotic        solvent capable of forming a low-boiling azeotrope with water,        wherein        -   Z is phenyl optionally substituted with up to 5 substituents            independently selected from R²;        -   Q is phenyl or 1-naphthalenyl, each optionally substituted            with up to four substituents independently selected from R³;        -   each R² is independently halogen, C₁-C₆ alkyl, C₁-C₆            haloalkyl, C₁-C₆ alkoxy, C₁-C₆ haloalkoxy, C₁-C₆ alkylthio,            C₁-C₆ haloalkylthio, C₁-C₆ alkylamino, C₂-C₆ dialkylamino,            —CN or —NO₂;        -   each R³ is independently halogen, C₁-C₆ alkyl, C₁-C₆            haloalkyl, C₂-C₆ alkenyl, C₂-C₆ haloalkenyl, C₂-C₆ alkynyl,            C₃-C₆ haloalkynyl, C₃-C₆ cycloalkyl, C₃-C₆ halocycloalkyl,            C₁-C₆ alkoxy, C₁-C₆ haloalkoxy, C₁-C₆ alkylthio, C₂-C₇            alkylcarbonyl, C₂-C₇ haloalkylcarbonyl, C₁-C₆ haloalkylthio,            C₁-C₆ alkylsulfinyl, C₁-C₆ haloalkylsulfinyl, C₁-C₆            alkylsulfonyl, C₁-C₆ haloalkylsulfonyl, —N(R⁴)R⁵,            —C(═W)N(R⁴)R⁵, —C(═W)OR⁵, —CN, —OR¹¹ or —NO₂; or a phenyl            ring or a 5- or 6-membered saturated or unsaturated            heterocyclic ring, each ring optionally substituted with one            or more substituents independently selected from halogen,            C₁-C₆ alkyl, C₁-C₆ haloalkyl, C₃-C₆ cycloalkyl, C₃-C₆            halocycloalkyl, C₁-C₆ alkoxy, C₁-C₆ haloalkoxy, C₁-C₆            alkylthio, C₁-C₆ haloalkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆            haloalkylsulfinyl, C₁-C₆ alkylsulfonyl, C₁-C₆            haloalkylsulfonyl, —CN, —NO₂, —N(R⁴)R⁵, —C(═W)N(R⁴)R⁵,            —C(═O)OR⁵ and R⁷;        -   each R⁴ is independently H, C₁-C₆ alkyl, C₂-C₆ alkenyl,            C₂-C₆ alkynyl, C₃-C₆ cycloalkyl, C₄-C₇ alkylcycloalkyl,            C₄-C₇ cycloalkylalkyl, C₂-C₇ alkylcarbonyl or C₂-C₇            alkoxycarbonyl;        -   each R⁵ is independently H; or C₁-C₆ alkyl, C₂-C₆ alkenyl,            C₂-C₆ alkynyl, C₃-C₆ cycloalkyl, C₄-C₇ alkylcycloalkyl or            C₄-C₇ cycloalkylalkyl, each optionally substituted with one            or more substituents independently selected from R⁶;        -   each R⁶ is independently halogen, C₁-C₆ alkyl, C₁-C₆ alkoxy,            C₁-C₆ alkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆ alkylsulfonyl,            C₁-C₆ alkylamino, C₂-C₈ dialkylamino, C₃-C₆ cycloalkylamino,            C₂-C₇ alkylcarbonyl, C₂-C₇ alkoxycarbonyl, C₂-C₇            alkylaminocarbonyl, C₃-C₉ dialkylaminocarbonyl, C₂-C₇            haloalkylcarbonyl, C₂-C₇ haloalkoxycarbonyl, C₂-C₇            haloalkylaminocarbonyl, C₃-C₉ halodialkylaminocarbonyl, —OH,            —NH₂, —CN or —NO₂; or Q¹;        -   each R⁷ is independently a phenyl ring or a pyridinyl ring,            each ring optionally substituted with one or more            substituents independently selected from R⁸;        -   each R⁸ is independently halogen, C₁-C₆ alkyl, C₁-C₆            haloalkyl, C₁-C₆ alkoxy, C₁-C₆ haloalkoxy, C₁-C₆ alkylthio,            C₁-C₆ haloalkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆            haloalkylsulfinyl, C₁-C₆ alkylsulfonyl, C₁-C₆            haloalkylsulfonyl, C₁-C₆ alkylamino, C₂-C₆ dialkylamino,            C₂-C₄ alkylcarbonyl, C₂-C₄ alkoxycarbonyl, C₂-C₇            alkylaminocarbonyl, C₃-C₇ dialkylaminocarbonyl, —OH, —NH₂,            —C(═O)OH, —CN or —NO₂;        -   each Q¹ is independently a phenyl ring or a 5- or 6-membered            saturated or unsaturated heterocyclic ring, each ring            optionally substituted with one or more substituents            independently selected from halogen, C₁-C₆ alkyl, C₁-C₆            haloalkyl, C₃-C₆ cycloalkyl, C₃-C₆ halocycloalkyl, C₁-C₆            alkoxy, C₁-C₆ haloalkoxy, C₁-C₆ alkylthio, C₁-C₆            haloalkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆ haloalkylsulfinyl,            C₁-C₆ alkylsulfonyl, C₁-C₆ haloalkylsulfonyl, C₁-C₆            alkylamino, C₂-C₆ dialkylamino, —CN, —NO₂, —C(═W)N(R⁹)R¹⁰            and —C(═O)OR¹⁰;        -   each R⁹ is independently H, C₁-C₆ alkyl, C₁-C₆ haloalkyl,            C₂-C₆ alkenyl, C₂-C₆ alkynyl, C₃-C₆ cycloalkyl, C₄-C₇            alkylcycloalkyl, C₄-C₇ cycloalkylalkyl, C₂-C₇ alkylcarbonyl            or C₂-C₇ alkoxycarbonyl;        -   each R¹⁰ is independently H; or C₁-C₆ alkyl, C₁-C₆            haloalkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, C₃-C₆ cycloalkyl,            C₄-C₇ alkylcycloalkyl or C₄-C₇ cycloalkylalkyl;        -   each R¹¹ is independently H; or C₂-C₆ alkenyl, C₂-C₆            alkynyl, C₃-C₆ cycloalkyl, C₄-C₇ alkylcycloalkyl, C₄-C₇            cycloalkylalkyl, C₂-C₇ alkylcarbonyl, C₂-C₇ alkoxycarbonyl,            C₁-C₆ alkylsulfonyl or C₁-C₆ haloalkylsulfonyl; and        -   each W is independently O or S.    -   Embodiment A1. The method of Embodiment A wherein the base is an        alkaline earth metal hydroxide of Formula 4 and the mixture        further comprises a polar aprotic solvent.    -   Embodiment A2. The method of Embodiment A or A1 wherein Q is        phenyl optionally substituted with up to four substituents        independently selected from R³.    -   Embodiment A3. The method of Embodiment A or A1 wherein Q is        1-naphthalenyl optionally substituted with up to four        substituents independently selected from R³.    -   Embodiment A4. The method of Embodiment A, A1 or A2 wherein        -   each R² is independently halogen or C₁-C₆ haloalkyl;        -   each R³ is independently halogen, C₁-C₆ alkyl, C₁-C₆            haloalkyl, —C(W)N(R⁴)R⁵, —C(W)OR⁵ or —CN; or a phenyl ring            or a 5- or 6-membered heterocyclic ring, each ring            optionally substituted with one or more substituents            independently selected from halogen, C₁-C₆ alkyl, C₁-C₆            haloalkyl, —CN, —C(W)N(R⁴)R⁵ and —C(O)OR⁵;        -   each R⁴ is independently H or C₁-C₆ alkyl;        -   each R⁵ is independently H; or C₁-C₆ alkyl optionally            substituted with one or more substituents independently            selected from R⁶;        -   each R⁶ is independently halogen, C₁-C₆ alkyl, C₁-C₆ alkoxy,            C₁-C₆ alkylthio, C₂-C₇ alkoxycarbonyl, C₂-C₇            alkylaminocarbonyl, C₃-C₉ dialkylaminocarbonyl, C₂-C₇            haloalkylaminocarbonyl, C₃-C₉ halodialkylaminocarbonyl or            —CN; or Q¹; and        -   each Q¹ is independently a pyridinyl ring optionally            substituted with up to 4 halogen.    -   Embodiment A5. The method of Embodiment A3 wherein        -   Z is

-   -   -   Q is

-   -   -   R^(2a) is halogen, C₁-C₂ haloalkyl or C₁-C₂ haloalkoxy;        -   R^(2b) is H, halogen or cyano;        -   R^(2c) is H, halogen or CF₃;        -   R³ is C(O)N(R⁴)R⁵ or C(O)OR^(5a);        -   R⁴ is H, C₂-C₇ alkylcarbonyl or C₂-C₇ alkoxycarbonyl; and        -   R⁵ is C₁-C₆ alkyl or C₁-C₆ haloalkyl, each substituted with            one substituent independently selected from hydroxy, C₁-C₆            alkoxy, C₁-C₆ alkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆            alkylsulfonyl, C₂-C₇ alkylaminocarbonyl, C₃-C₉            dialkylaminocarbonyl, C₂-C₇ haloalkylaminocarbonyl and C₃-C₉            halodialkylaminocarbonyl; and        -   R^(5a) is C₁-C₆ alkyl, C₂-C₆ alkenyl or C₂-C₆ alkynyl, each            optionally substituted with one or more substituents            independently selected from halogen, C₁-C₂ alkoxy and phenyl            optionally substituted with up to 5 substituents selected            from halogen and C₁-C₃ alkyl.

    -   Embodiment A6. The method of Embodiment A5 wherein R³ is        C(O)N(R⁴)R⁵.

    -   Embodiment A7. The method of Embodiment A5 wherein R³ is        C(O)OR^(5a).

    -   Embodiment B. The method described in the Summary of the        Invention for preparing the compound of Formula 1 comprising        distilling water from the mixture comprising the compound of        Formula 2, the compound of Formula 3, the base, and the aprotic        solvent capable of forming a low-boiling azeotrope with water,        wherein        -   Z is phenyl optionally substituted with up to 5 substituents            independently selected from R² (i.e.

-   -   -   -   wherein n is 0, 1, 2, 3, 4 or 5); and

        -   each R² is independently F, Cl, Br, C₁-C₆ alkyl, C₁-C₆            fluoroalkyl, C₁-C₆ alkoxy, C₁-C₆ fluoroalkoxy, C₁-C₆            alkylthio or C₁-C₆ fluoroalkylthio;

    -   further comprising preparing the compound of Formula 2 by

    -   (1) forming a reaction mixture comprising a Grignard reagent        derived from a compound of Formula 5

Z—X   5

-   -   wherein X is Cl, Br or I,    -   by contacting the compound of Formula 5 with    -   (a) magnesium metal, or    -   (b) an alkylmagnesium halide    -   in the presence of an ethereal solvent; and then    -   (2) contacting the reaction mixture with a compound of Formula 6

-   -   wherein        -   Y is OR¹¹ or NR¹²R¹³;        -   R¹¹ is C₁-C₅ alkyl; and        -   R¹² and R¹³ are independently C₁-C₂ alkyl; or R¹² and R¹³            are taken together as —CH₂CH₂OCH₂CH₂—.    -   Embodiment B1. The method of Embodiment B wherein the base is an        alkaline earth metal hydroxide of Formula 4 and the mixture        further comprises a polar aprotic solvent.    -   Embodiment B2. The method of Embodiment B or B1 wherein Z is

-   -   -   R^(2a) is F, Cl, Br, C₁-C₂ fluoroalkyl or C₁-C₂            fluoroalkoxy;        -   R^(2b) is H, F, Cl or Br; and        -   R^(2c) is H, F, Cl, Br or CF₃.

    -   Embodiment C. The method described in the Summary of the        Invention for preparing a compound of Formula 2, comprising (1)        forming a reaction mixture comprising a Grignard reagent derived        from a compound of Formula 5 by contacting the compound of        Formula 5 with (a) magnesium metal, or (b) an alkylmagnesium        halide in the presence of an ethereal solvent; and then (2)        contacting the reaction mixture with a compound of Formula 6,        wherein        -   X is I;        -   Z is phenyl optionally substituted with up to 5 substituents            independently selected from R² (i.e.

-   -   -   -   wherein n is 0, 1, 2, 3, 4 or 5); and

        -   each R² is independently F, Cl, Br, C₁-C₆ alkyl, C₁-C₆            fluoroalkyl, C₁-C₆ alkoxy, C₁-C₆ fluoroalkoxy, C₁-C₆            alkylthio or C₁-C₆ fluoroalkylthio.

    -   Embodiment C1. The method of Embodiment C wherein Z is

-   -   -   R^(2a) is F, Cl, Br, C₁-C₂ fluoroalkyl or C₁-C₂            fluoroalkoxy;        -   R^(2b) is H, F, Cl or Br; and        -   R^(2c) is H, F, Cl, Br or CF₃.

    -   Embodiment D. A method for preparing a compound of Formula 7

-   -   wherein        -   Z is optionally substituted phenyl; and        -   Q is phenyl or 1-naphthalenyl, each optionally substituted;    -   using a compound of Formula 1

-   -   characterized by: preparing said compound of Formula 1 by the        method described in the Summary of the Invention for preparing        the compound of Formula 1 comprising distilling water from the        mixture comprising the compound of Formula 2, the compound of        Formula 3, the base, and the aprotic solvent capable of forming        a low-boiling azeotrope with water.    -   Embodiment D1. The method of Embodiment D wherein the base is an        alkaline earth metal hydroxide of Formula 4 and the mixture        further comprises a polar aprotic solvent.    -   Embodiment D2. The method of Embodiment D or D1 wherein        -   Z is

-   -   -   Q is

-   -   -   R^(2a) is halogen, C₁-C₂ haloalkyl or C₁-C₂ haloalkoxy;        -   R^(2b) is H, halogen or cyano;        -   R^(2c) is H, halogen or CF₃;        -   R⁴ is H, C₂-C₇ alkylcarbonyl or C₂-C₇ alkoxycarbonyl; and        -   R⁵ is C₁-C₆ alkyl or C₁-C₆ haloalkyl, each substituted with            one substituent independently selected from hydroxy, C₁-C₆            alkoxy, C₁-C₆ alkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆            alkylsulfonyl, C₂-C₇ alkylaminocarbonyl, C₃-C₉            dialkylaminocarbonyl, C₂-C₇ haloalkylaminocarbonyl and C₃-C₉            halodialkylaminocarbonyl.

    -   Embodiment E. A method for preparing a compound of Formula 7

-   -   wherein        -   Z is optionally substituted phenyl; and        -   Q is phenyl or 1-naphthalenyl, each optionally substituted;    -   using a compound of Formula 1

-   -   characterized by: using as said compound of Formula 1 a compound        of Formula 1 prepared by the method described in the Summary of        the Invention for preparing the compound of Formula 1 comprising        distilling water from the mixture comprising the compound of        Formula 2, the compound of Formula 3, the base, and the aprotic        solvent capable of forming a low-boiling azeotrope with water.    -   Embodiment E1. The method of Embodiment E wherein the base is an        alkaline earth metal hydroxide of Formula 4 and the mixture        further comprises a polar aprotic solvent.    -   Embodiment E2. The method of Embodiment E or E1 wherein        -   Z is

-   -   -   Q is

-   -   -   R^(2a) is halogen, C₁-C₂ haloalkyl or C₁-C₂ haloalkoxy;        -   R^(2b) is H, halogen or cyano;        -   R^(2c) is H, halogen or CF₃;        -   R⁴ is H, C₂-C₇ alkylcarbonyl or C₂-C₇ alkoxycarbonyl; and        -   R⁵ is C₁-C₆ alkyl or C₁-C₆ haloalkyl, each substituted with            one substituent independently selected from hydroxy, C₁-C₆            alkoxy, C₁-C₆ alkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆            alkylsulfonyl, C₂-C₇ alkylaminocarbonyl, C₃-C₉            dialkylaminocarbonyl, C₂-C₇ haloalkylaminocarbonyl and C₃-C₉            halodialkylaminocarbonyl.

In the following Schemes 1-10 the definitions of Z, Q, R², R³, R⁴, R⁵,R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹², R¹³ and W in the compounds of Formulae 1through 7 and 11 through 15 are as defined above in the Summary of theInvention and description of Embodiments unless otherwise indicated.Formula la is a subset of Formula 1. Formula 5a is a subset of Formula5. Formulae 7a, 7b, 7c, 7d, 7e and 7f are subsets of Formula 7. Formula13a is a subset of Formula 13.

In the method of the invention illustrated in Scheme 1, a compound ofFormula 1 is prepared by distilling water from a mixture comprising acompound of Formula 2, a compound of Formula 3, an alkaline earth metalhydroxide base of Formula 4, a polar aprotic solvent, and an aproticsolvent capable of forming a low-boiling azeotrope with water.

wherein M is Ca, Sr or Ba.

The first step of this reaction involves an aldol condensation to form acompound of Formula 11. The compound of Formula 11 is not isolated, butinstead under the reaction conditions is converted to the compound ofFormula 1.

The stoichiometry of this reaction involves equimolar amounts of thecompounds of Formula 2 and Formula 3, and using equimolar amountstypically is most cost-effective. However, small molar excesses of oneof the reactants are not deleterious to the reaction, and if one of thereactants is much less expensive or more preparatively accessible, usingit in a slight excess (e.g., 1.05 molar equivalents) may be desirable toensure complete conversion of the more expensive or less preparativelyaccessible reactant.

Alkaline earth metal hydroxides of Formula 4 and compounds capable offorming said alkaline earth metal hydroxides on contact with water havebeen discovered to be particularly efficacious in providing high yieldsof compounds of Formula 1. These alkaline earth metal hydroxide basesinclude calcium, strontium or barium hydroxides, with calcium hydroxidepreferred for its low cost. The alkaline earth metal hydroxides ofFormula 4 can be formed in situ from compounds capable of formingalkaline earth metal hydroxides on contact with water (identified hereinas “alkaline earth metal hydroxide precursors”) such as alkaline earthmetal hydrides. Alkaline earth metal hydroxide precursors can react withwater present in the reaction mixture, including water formed by thereaction, to form the corresponding alkaline earth metal hydroxides.Alkaline earth metal hydrides are preferred as precursors, as theirreaction to form alkaline earth metal hydroxides removes water formed bythe reaction without distillation. Calcium hydride is particularlypreferred as an alkaline earth metal hydroxide precursor because of itscommercial availability and relatively low cost. Although calciumhydride is advantageous for directly removing water, adding calciumhydroxide to form the reaction mixture is preferred for the method ofScheme 1, in which water is removed by azeotropic distillation, becausecalcium hydroxide does not form hydrogen gas and is easier to scale up,and inherently safer to use than a metal hydride on a large scale.

The alkaline earth metal hydroxide is added to form the reaction mixturesuch that the molar ratio of alkaline earth metal hydroxide to thecompound of Formula 3 is typically in the range of about 0.1 to about 1.Typically a ratio in the range of about 0.5 to about 1 provides a rapidrate of reaction and high product yields.

In the present method the reaction mixture comprises both a polaraprotic solvent and an aprotic solvent capable of forming a low-boilingazeotrope with water. The polar aprotic solvent can comprise a mixtureof polar aprotic solvent compounds, but typically is a single polaraprotic solvent compound. As is generally understood in the art, aproticsolvent means a liquid compound that does not have —OH or —NH moietiesin its molecular structure. Also as is generally understood in the art,polar solvent means a liquid compound that has a dielectric constantgreater than 15. For the present method, polar aprotic solvents ofparticular note are sufficiently polar to be miscible with water in allproportions at room temperature (e.g., about 20 to 25° C.). The polaraprotic solvent most preferably has a boiling point higher than theboiling point of the low-boiling azeotrope, so that the polar aproticsolvent is not removed from the reaction mixture. These properties arebest provided by amide and sulfoxide solvents, which are commerciallyavailable at relatively low cost. By amide solvents is meant solventcompounds containing a carboxamide molecular moiety. Common examples ofamide solvents are N,N-dimethylformamide, NN-dimethylacetamide andN-methylpyrrolidinone. Sulfoxide solvents comprise a sulfoxide molecularmoiety; common examples include dimethyl sulfoxide (also known as methylsulfoxide) and sulfolane. N,N-dimethylformamide is most preferred, as itprovides excellent results, has a boiling point substantially greaterthan water but still can be readily removed by distillation, and iscommercially available at relatively low cost.

In the present method, inclusion of an aprotic solvent capable offorming a low-boiling azeotrope with water facilitates removal bydistillation of water formed as a byproduct. The aprotic solvent isordinarily a single solvent compound, but can also be a mixture ofsolvent compounds (e.g., xylene isomers). By low-boiling azeotrope ismeant an azeotrope having a boiling point less than both the boilingpoint of water and the boiling point of the aprotic solvent. Bydefinition, low-boiling azeotropes containing water have normal boilingpoints of less than 100° C. (i.e. the normal boiling point of water).Thus the boiling point of the low-boiling azeotrope will besubstantially less than the boiling points of the compounds of Formulae1, 2 and 3, and these compounds will remain in the reaction mixtureduring distillation. As already mentioned, preferably the polar aproticsolvent and the aprotic solvent capable of forming a low-boilingazeotrope are selected so that the polar aprotic solvent has a boilingpoint higher than the azeotrope so that the polar aprotic solvent is notremoved during the distillation. Aprotic solvents forming azeotropeswith water are well known in the art, and compendia have been publishedlisting their boiling points (see, for example, Azeotropic Data, Number6 in the Advances in Chemistry Series, American Chemical Society,Washington, D.C., 1952, particularly pages 6-12). Examples of suitableaprotic solvents forming low-boiling azeotropes with water includeesters such as ethyl acetate, aromatic hydrocarbons such as benzene andtoluene, and ethers such as tert-butyl methyl ether, tetrahydrofuran and1,4-dioxane. Preferably, the azeotrope formed by the aprotic solvent andwater contains a higher percentage of water than is soluble in theaprotic solvent at room temperature (e.g., 15-35° C.), thus facilitatinglarge-scale separation of water from the condensed azeotrope in adecanter trap, and recycling the water-depleted aprotic solvent to themiddle of the distillation column. Therefore water-immiscible aproticsolvents such as ethyl acetate, benzene, toluene and tert-butyl methylether are preferred over tetrahydrofuran and 1,4 dioxane, which aremiscible with water.

Tert-butyl methyl ether has been discovered to be particularly useful asan aprotic solvent in the present method. Tert-butyl methyl ether formsa water azeotrope boiling at 52.6° C. and containing 4% water and 96%tert-butyl methyl ether, and therefore is able to rapidly transfer waterby distillation from the reaction mixture. Furthermore, water is solublein tert-butyl methyl ether to the extent of only about 1%. Therefore inlarge-scale preparations wherein the amount of tert-butyl methyl etherin the decanter trap is not sufficient to dissolve all the water formedby the reaction, the condensate in the trap will separate into an upperlayer comprising tert-butyl methyl ether containing only about 1% water,which can be returned to the middle of the distillation column, and alower layer comprising predominately water, which can be removed. Inaddition, the relatively low boiling points of tert-butyl methyl etherand its azeotrope with water accommodate selecting a wide range ofreaction temperatures by adjusting the proportion of tert-butyl methylether combined with a polar aprotic solvent having a boiling point above100° C., particularly above 120° C. (e.g., N,N-dimethylformamide). Forexample, reaction mixtures comprising much more tert-butyl methyl etherthan N,N-dimethylformamide (DMF) can boil at pot temperatures not muchabove 55° C., while a reaction mixtures comprising little tert-butylmethyl ether relative to DMF can boil at a pot temperatures above 100°C. Typically the tert-butyl methyl ether and N,N-dimethylformamide arein a weight ratio in a range from about 0.5 to about 2.

The reaction of the method of Scheme 1 can be conducted over a widerange of temperatures. Typically the reaction temperature is at leastabout 65° C. Although the reaction proceeds at lower temperatures, therates are slower, and aprotic solvent-water azeotropes boiling below 50°C. typically comprise relatively little water (e.g., dichloromethaneforms azeotrope containing 1.5% water), which slows water removal. Moretypically the reaction temperature is at least about 70° C. and mosttypically at least about 75° C. Although high temperatures increase thereaction rate, they can also cause side reactions decreasing productpurity and yield. Therefore typically the reaction temperature is notmore than about 110° C., more typically not more than about 100° C., andmost typically not more than about 90° C.

The compounds of Formulae 2 and 3, alkaline earth metal hydroxide ofFormula 4 (or a precursor such as an alkaline earth metal hydride),polar aprotic solvent and aprotic solvent capable of forming alow-boiling azeotrope can be combined in any convenient order to formthe reaction mixture.

Reaction progress can be monitored by conventional methods such as thinlayer chromatography, HPLC and ¹H NMR analyses of aliquots. Aftercompletion of the reaction, the mixture is typically cooled to roomtemperature and the product isolated by conventional methods, such asfiltration, extraction, distillation and crystallization. For example,alkali metal hydroxides and other solids can be mostly removed byfiltration. Water can be added to the filtrate, followed by a strongacid (such as hydrochloric acid) to neutralize any remaining base andhelp remove polar solvents such as DMF. Separation of the organic phase,further washing with water to remove polar solvents such as DMF, dryingover desiccants such as magnesium sulfate or molecular sieves, and thenevaporation of the solvent leaves the product, often as a crystallinesolid, which can be recrystallized from solvents such as hexanes.

For large-scale preparations in which drying with desiccants isimpractical, the separated organic phase can be dried and concentratedby removing by distillation both water and the aprotic solvent capableof forming an azeotrope with water (subsequently referred to herein asthe “Reaction Azeotrope Solvent”). The residue can then be diluted witha nonpolar solvent having a boiling point higher than the ReactionAzeotrope Solvent (e.g., hexanes fraction having a 65-70° C. normalboiling point when the Reaction Azeotrope Solvent is tert-butyl methylether) and distillation continued to remove the residual ReactionAzeotrope Solvent and optionally some of the nonpolar solvent. Oftencooling the mixture comprising product and the nonpolar solvent causescrystallization of the product. Alternatively, the nonpolar solvent canbe removed by further distillation or evaporation to leave the product.

Instead of isolating the product, transferring the product to a solventuseful for a subsequent reaction (e.g., the method of Scheme 6) may bemore convenient. After removing by distillation both water and theReaction Azeotrope Solvent, the residue can be diluted with a solventuseful in the subsequent reaction (referred to herein as the“Replacement Reaction Solvent”). Minor amounts of residual ReactionAzeotrope Solvent may be acceptable in the subsequent reaction.Alternatively, if the Replacement Reaction Solvent has a boiling pointhigher than the Reaction Azeotrope Solvent (e.g., tetrahydrofuran asReplacement Reaction Solvent when the Reaction Azeotrope Solvent istert-butyl methyl ether), the residual Reaction Azeotrope Solvent can beeasily removed by distillation.

The method of Scheme 1 typically provides the compound of Formula 1 as amixture of E and Z geometric isomers (denoted by the wavy line inFormula 1), in which one isomer may predominate. Purification methodssuch as recrystallization often provide purified products containingmostly or exclusively a single geometric isomer.

In an alternative method for preparing compounds of Formula 1, compoundsof Formulae 2 and 3 are contacted with an alkaline earth metal hydridesuch as calcium hydride in the presence of a polar aprotic solvent suchas DMF without needing to include an aprotic solvent capable of forminga low-boiling azeotrope with water or distilling water from the mixture.In this method the alkaline earth metal hydride serves both as a sourceof base to catalyze the condensation and a drying agent to remove waterformed as a byproduct. As the alkaline metal hydride serves as theprimary drying agent, stoichiometry requires a molar ratio of at least0.5 relative to the compounds of Formulae 2 and 3. Typically a ratio ofabout 1.3 provides a rapid rate of reaction and high product yields.Alkaline earth metal hydrides generally have little solubility insolvents inert to them, so small particle size improves mass transferand the availability of these reagents to react (e.g., with water).Although typically a molar ratio of alkaline metal hydride to thecompound of Formula 3 of not more than about 2 is needed for bestresults (i.e. high conversion and product yields), large particle sizeof alkaline earth metal hydrides may require a molar ratio of hydride tothe compound of Formula 3 of more than 2 for best results. This methodis typically conducted at a temperature of at least about 45° C., moretypically at least about 55° C., and typically not more than about 100°C., more typically not more than about 80° C.

In the method of the invention illustrated in Scheme 1 a, a compound ofFormula 1 is prepared by distilling water from a mixture comprising acompound of Formula 2, a compound of Formula 3, an alkali metalcarbonate base of Formula 4a, and an aprotic solvent capable of forminga low-boiling azeotrope with water.

wherein M¹ is Li, Na or K.

The first step of this reaction involves an aldol condensation to form acompound of Formula 11. The compound of Formula 11 is not isolated, butinstead under the reaction conditions is converted to the compound ofFormula 1.

The stoichiometry of this reaction involves equimolar amounts of thecompounds of Formula 2 and Formula 3 as described for Scheme 1.

Alkali metal carbonates of Formula 4a have been discovered to beparticularly efficacious in providing high yields of compounds ofFormula 1. These alkali metal carbonate bases include lithium, sodium orpotassium carbonate, with potassium carbonate preferred for its lowcost.

The alkali metal carbonate is added to form the reaction mixture suchthat the molar ratio of alkali metal carbonate to the compound ofFormula 3 is typically in the range of about 0.01 to about 0.2.Typically a ratio in the range of about 0.03 to about 0.05 providescomplete conversion of compounds of Formula 3 to compounds of Formula 1.The alkali metal carbonate can be added to the reaction mixture in smallportions so that the rate of reaction can be controlled, and the rate ofgeneration of water in the reaction vessel can be matched to the rate ofwater removal by distillation of the solvent/water azeotrope.

In the method of Scheme 1a, acetonitrile has been discovered to beparticularly useful as an aprotic solvent in the present method.Acetonitrile forms a water azeotrope boiling at 76.5° C. and containingabout 16.3% water and about 83.7% acetonitrile by weight, and thereforeis able to rapidly transfer water by distillation from the reactionmixture.

The reaction of the method of Scheme 1a can be conducted over a widerange of temperatures. Typically the reaction temperature is at leastabout 65° C. Although the reaction proceeds at lower temperatures, therates are slower, and aprotic solvent-water azeotropes boiling below 50°C. typically comprise relatively little water (e.g., dichloromethaneforms azeotrope containing 1.5% water), which slows water removal. Moretypically the reaction temperature is at least about 80° C. and mosttypically at least about 85° C. Although high temperatures increase thereaction rate, they can also cause side reactions decreasing productpurity and yield. Therefore typically the reaction temperature is notmore than about 110° C., more typically not more than about 100° C., andmost typically not more than about 90° C.

In the method of the invention illustrated in Scheme 1b, a compound ofFormula 1 is prepared by distilling water from a mixture comprising acompound of Formula 2, a compound of Formula 3, a base selected from1,5-diazabicyclo[4.3.0]non-5-ene, 1,8-diazabicyclo[5.4.0]undec-7-ene,and mixtures thereof, and an aprotic solvent capable of forming alow-boiling azeotrope with water.

wherein base is 1,5-diazabicyclo[4.3.0]non-5-ene,1,8-diazabicyclo[5.4.0]undec-7-ene or a mixture thereof.

The first step of this reaction involves an aldol condensation to form acompound of Formula 11. The compound of Formula 11 is not isolated, butinstead under the reaction conditions is converted to the compound ofFormula 1.

The stoichiometry of this reaction involves equimolar amounts of thecompounds of Formula 2 and Formula 3 as described for Scheme 1.

1,5-Diazabicyclo[4.3.0]non-5-ene, 1,8-diazabicyclo[5.4.0]undec-7-ene ormixtures thereof have been discovered to be particularly efficacious inproviding high yields of compounds of Formula 1. Both1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo-[5.4.0]undec-7-eneare liquids at 25° C. On a large (i.e. commercial) scale, liquids can beadded to a reaction mixture more accurately and with less material lossthan solids.

1,5-Diazabicyclo[4.3.0]non-5-ene, 1,8-diazabicyclo[5.4.0]undec-7-ene ora mixture thereof is added to form the reaction mixture such that themolar ratio of 1,5-diazabicyclo[4.3.0]non-5-ene,1,8-diazabicyclo[5.4.0]undec-7-ene or a mixture thereof to the compoundof Formula 3 is typically in the range of about 0.01 to about 0.2.Typically a ratio in the range of about 0.03 to about 0.05 provides arapid rate of reaction and high product yields. The1,5-diazabicyclo[4.3.0]non-5-ene, 1,8-diazabicyclo[5.4.0]undec-7-ene ormixture thereof can be added to the reaction mixture in small portionsso that the rate of reaction can be controlled, and the rate ofgeneration of water in the reaction vessel can be matched to the rate ofwater removal by distillation of the solvent/water azeotrope.

In the method of Scheme 1b, acetonitrile has been discovered to beparticularly useful as an aprotic solvent in the present method.Acetonitrile forms a water azeotrope boiling at 76.5° C. and containing16.3% water and 83.7% acetonitrile by weight, and therefore is able torapidly transfer water by distillation from the reaction mixture.

The reaction of the method of Scheme 1b can be conducted over a widerange of temperatures. Typically the reaction temperature is at leastabout 65° C. Although the reaction proceeds at lower temperatures, therates are slower, and aprotic solvent-water azeotropes boiling below 50°C. typically comprise relatively little water (e.g., dichloromethaneforms azeotrope containing 1.5% water), which slows water removal. Moretypically the reaction temperature is at least about 80° C. and mosttypically at least about 85° C. Although high temperatures increase thereaction rate, they can also cause side reactions decreasing productpurity and yield. Therefore typically the reaction temperature is notmore than about 110° C., more typically not more than about 100° C., andmost typically not more than about 90° C.

Regarding the methods of Schemes 1, 1a and 1b, and the above-describedalternative method for preparing compounds of Formula 1, in theirbroadest definitions Z in Formulae 1 and 2 is optionally substitutedphenyl, and Q in Formulae 1 and 3 is phenyl or 1-naphthalenyl, eachoptionally substituted. Q and Z are appendages not directly involved inthe aldol condensation and dehydration providing compounds of Formula 1.The reaction conditions for the present methods are relatively mild andthus accommodate a wide range of optional substituents on phenyl and1-naphthalenyl. Only functionalities most reactive to hydroxide basesare susceptible to being affected. Therefore the particular substituentson the phenyl and 1-naphthalenyl moieties of Q and Z described in theEmbodiments (e.g., 1 through 1G, 2 through 2O, A through A7) andelsewhere in the present disclosure should be regarded as merelyillustrative, as the scope of utility of the present methods is moregeneral.

In the method of the present invention illustrated in Scheme 2, acompound of Formula 2 is prepared from a corresponding compound ofFormula 5 by forming a Grignard reagent intermediate (depicted asFormula 12), and then reacting the Grignard reagent with a compound ofFormula 6.

In one embodiment of this method, a compound of Formula 5 is contactedwith magnesium metal in the presence of an ethereal solvent to form aGrignard reagent. In the context of the present disclosure and claims,an ethereal solvent contains one or more organic compounds consisting ofatoms selected hydrogen, carbon and oxygen and having at least one etherlinkage (i.e. C—O—C) but no other functionality. Common examples ofethers include diethyl ether, tetrahydrofuran, 1,4-dioxane and1,2-dimethoxyethane, but other ethers such as butyl diglyme(1,1′-[oxybis(2,1-ethanediyloxy)]bisbutane) are also employed to prepareand use Grignard reagents. Typically in this embodiment, the etherealsolvent comprises diethyl ether or tetrahydrofuran. More typically theethereal solvent comprises tetrahydrofuran. When the Grignard reagent isprepared using magnesium metal, X¹ in Scheme 2 is the same as X if noother anionic species are added to the reaction mixture. For preparingGrignard reagents from magnesium metal, the metal is typically in theform of turnings, shavings or powder to provide high surface area forreaction. Typically the magnesium metal is contacted with the compoundof Formula 5 at a temperature of at least about 0° C., more typically atleast about 20° C., and most typically at least about 25° C. Typicallythe temperature is no more than about 65° C., more typically no morethan about 40° C., and most typically no more than about 35° C. Asstoichiometry requires at least equimolar amounts of magnesium metalrelative to the compound of Formula 5 for complete conversion, the molarratio of magnesium metal to the compound of Formula 5 is typically atleast about 1, more typically at least about 1.02 and most typically atleast about 1.05. Although larger excesses of magnesium metal can beused, they provide no advantage and increase solid residues. Typicallythe molar ratio of magnesium metal to the compound of Formula 5 is nomore than about 1.2, and more typically no more than about 1.1.

Alternatively in another embodiment of this method, the Grignard reagentis prepared by contacting the compound of Formula 5 with analkylmagnesium halide. For an example of this general method of formingGrignard reagents, see J. L. Leazer and R. Cvetovich, Org. Syn. 2005,82, 115-119. The alkylmagnesium halide is typically a secondaryalkylmagnesium halide, which is more reactive than a primaryalkylmagnesium halide. Typically the alkylmagnesium halide is a C₁-C₄alkylmagnesium halide. Of note is the alkylmagnesium halide being anisopropylmagnesium halide, particularly isopropylmagnesium chloride. Inthis embodiment of the present method, X¹ in Scheme 2 represents amixture of anions provided both by X in the compound of Formula 5 andthe halide of the alkylmagnesium halide. For example, if X is I and thealkylmagnesium halide is isopropylmagnesium chloride, then X¹ representsa mixture of Cl and I (present as anions). In this embodiment, thecompound of Formula 5 is contacted with the alkylmagnesium halide in thepresence of an ethereal solvent. Typically the compound of Formula 5 iscontacted with the alkylmagnesium halide at a temperature of at least−30° C., more typically at least −20° C. and most typically at leastabout −10° C. Typically the temperature is no more than about 40° C.,more typically no more than about 20° C., and most typically no morethan about 10° C. Typically in this embodiment, the ethereal solventcomprises diethyl ether, tetrahydrofuran or a mixture thereof, and moretypically the ethereal solvent comprises tetrahydrofuran. Asstoichiometry requires at least equimolar amounts of alkylmagnesiumhalide relative to the compound of Formula 5 for complete conversion,the molar ratio of the alkyl magnesium halide to the compound of Formula5 is typically at least about 1, and more typically at least about 1.05.Although larger excesses of alkylmagnesium halide can be used, they cansubsequently react with the compound of Formula 6, so that more compoundof Formula 6 is required and more byproduct is produced. Typically themolar ratio of the alkyl magnesium halide to the compound of Formula 5is no more than about 1.2, and more typically no more than about 1.15.However, larger amounts of alkylmagnesium halide can be desirable tocompensate for water impurities in the reaction solvent.

As is well known in the art, Grignard reagents react very rapidly withsolvents containing hydroxy groups, including water, and thus solventsfor preparing and using Grignard reagents should contain as littleimpurity water as feasible, i.e. be anhydrous. Also, as Grignardreagents react with oxygen, the reaction mixtures are preferablyprotected from oxygen, e.g., by being blanketed by nitrogen or argongas.

For both embodiments of this method, and particularly the embodimentforming the Grignard reagent using an alkylmagnesium halide, the methodcan be conducted in the presence of an aromatic hydrocarbon solvent inaddition to the ethereal solvent. The term “aromatic hydrocarbonsolvent” in this method denotes a solvent comprising one or morearomatic hydrocarbon compounds. Aromatic hydrocarbon compounds containonly carbon and hydrogen atoms and for aromaticity comprise at least onebenzene ring, which can be substituted with hydrocarbon moieties such asalkyl groups. Aromatic hydrocarbon solvents commonly comprise one ormore of benzene, toluene and xylene (which is typically present as amixture of isomers). Because aromatic hydrocarbon solvents are higherboiling than common ethereal solvents such as diethyl ether andtetrahydrofuran, including aromatic hydrocarbon solvents in the reactionmixture forming the Grignard reagent improves the margin of safety inlarge-scale production. The formation of Grignard reagents is generallyexothermic, and in the event of loss of cooling and subsequent loss ofthe lower boiling ethereal solvent, the presence of the higher boilingaromatic hydrocarbon solvent will curtail the reaction. For the presentmethod, toluene is particularly preferred as the aromatic hydrocarbonsolvent, because of its low cost, relatively low toxicity, low freezingpoint and moderately high boiling point.

According to this method, the reaction mixture containing the Grignardreagent formed from the compound of Formula 5 is then contacted with acompound of Formula 6 to give a compound of Formula 2. The compound ofFormula 6 is typically contacted with the reaction mixture containingthe Grignard reagent at a temperature of at least about −80° C., moretypically at least about −25° C., and most typically at least about −5°C. The temperature is typically no more than about 0° C. Typically thecompound of Formula 6 is added to the reaction mixture containing theGrignard reagent in solution, and an excess of compound of Formula 6relative to the Grignard reagent formed from the compound of Formula 5is used. Alternatively, the reaction mixture containing the Grignardreagent formed from the compound of Formula 5 can be added to an excessof the compound of Formula 6. When the Grignard reagent is prepared frommagnesium metal, the molar ratio of compound of Formula 6 relative tothe compound of Formula 5 is typically at least about 1.05 and moretypically at least about 1.1, and typically no more than about 1.3 andmore typically no more than about 1.2. When the Grignard reagent isprepared from an alkylmagnesium halide, the amount of alkylmagnesiumhalide used is more relevant than the amount of the compound of Formula5 relative to the compound of Formula 6, because excess alkylmagnesiumhalide can also react with the compound of Formula 6. In this embodimentthe ratio of the compound of Formula 6 to the alkylmagnesium halide usedis typically at least about 1.05 and more typically at least about 1.1,and typically no more than about 1.3 and more typically no more thanabout 1.2.

The reaction mixture is typically worked up by addition of an aqueousmineral acid such as hydrochloric acid, and extracting the product intomoderately polar, water-immiscible organic solvent such as diethylether, dichloromethane or toluene. Usually the compound of Formula 2 isobtained in a mixture with its hydrate derivative and its alkylhemi-ketal derivative (from alkanol byproduct formed from the compoundof Formula 6 when Y is OR¹¹). Either or both of these derivatives of thecompound of Formula 2 can be conveniently converted to the compound ofFormula 2 by treatment (i.e. contact) with a strong acid such as anorganic sulfonic acid, e.g., p-toluenesulfonic acid, in the presence ofan aprotic organic solvent, and removing the water and/or alkanol formedby distillation. Preferably the aprotic organic solvent is immisciblewith water. Typically the aprotic organic solvent comprises one or moresolvents selected from hydrocarbons such as heptane or toluene andhalogenated hydrocarbons such as 1,2-dichloroethane. During thedistillation, the reaction mixture in the pot is typically heated to atleast about 45° C., more typically at least about 80° C., typically nomore than about 120° C., more typically no more than about 110° C., andmost typically no more than about 100° C. Solvents such as heptane,toluene and 1,2-dichloroethane and their azeotropes with water andalkanols have normal boiling points accommodating these reactiontemperatures. Solvents such as toluene that form low-boiling azeotropeswith water and alkanols are preferred. After removal of water andalkanols, the distillation can be continued to remove the solvent, andcontinued at reduced pressure to isolate the product compound of Formula2.

The method of Scheme 2 is particularly useful when X is I (i.e. iodo),because this facilitates preparation of compounds of Formula 2 wherein Zis a phenyl ring optionally substituted with up to 5 substituentsselected from not just F, alkyl, fluoroalkyl, alkoxy, fluoroalkoxy,alkylthio and fluoroalkylthio, but also Cl and Br, which would be morelikely to react with magnesium metal or alkylmagnesium halides if X wereCl or Br. Although Grignard reagents are more often prepared fromchloro- or bromophenyl compounds, iodophenyl compounds (i.e. X is I) arediscovered to work well in forming Grignard reagents, and moreover whenX is I the phenyl ring can be substituted with halogens at otherpositions, particularly the 3- and 5-positions (relative to X), which isespecially useful for forming insecticidal 4,5-dihydroisoxazolecompounds.

Of note is the method of Scheme 2 wherein X is I and Z is phenylsubstituted at the 3- and 5-positions relative to X with substituentsindependently selected from F, Cl, Br and CF₃, particularly wherein onesubstituent is CF₃ and the other substituent is CF₃, Cl or Br, moreparticularly wherein one substituent is CF₃ and the other substituent isCl or Br, and most particularly wherein one substituent is CF₃ and theother substituent is Cl.

Compounds of Formulae 5 and 6 can be prepared by a wide variety ofmethods known in the art. Many of these compounds are known, and asubstantial number are commercially available. The above notedembodiment of the method of Scheme 2 involves compounds of Formula 5wherein X is I (e.g., 1-chloro-3-iodo-5-(trifluoromethyl)benzene). Thesecompounds can be prepared by the method illustrated in Scheme 3. In thismethod a compound of Formula 13 is diazotized to form a diazonium saltintermediate, which is then reduced to form the compound of Formula 5a(i.e. Formula 5 wherein X is I).

wherein R^(a) are substituents such as R² as defined in Embodiment 3H.In this method, a compound of Formula 13 is contacted with sodiumnitrite in the presence of a mineral acid such as hydrochloric acid orsulfuric acid. Usually for best results two or more molar equivalents ofthe mineral acid are required relative to the number of moles of thecompound of Formula 5a used in the reaction. The reaction is typicallyconducted in a suitable solvent such as aqueous hydrochloric acid oracetic acid. A temperature in the range from about −5 to about 5° C. isusually employed for the preparation of the diazonium salt. Thediazonium salt of a compound of Formula 13 is then contacted with areducing agent such as hypophosphorous acid or ethanol to provide acompound of Formula 5a. The reduction reaction is usually conducted inthe same solvent as was used for the diazonium salt formation at atemperature from about 5 to about 20° C. The product of Formula 5a canbe isolated by standard techniques such as crystallization, extraction,and distillation. The diazotization and reduction of anilines by thisgeneral method is well known and has been reviewed; see, for example, N.Kornblum, Org. Reactions 1944, 2, 262-340.

2-Chloro-6-iodo-4-(trifluoromethyl)benzenamine,4-chloro-2-iodo-6-(trifluoromethyl)-benzenamine and2-chloro-4-iodo-6-(trifluoromethyl)benzenamine are of particular note ascompounds of Formula 13 for preparing1-chloro-3-iodo-5-(trifluoromethyl)benzene as the compound of Formula 5aby this method.

Compounds of Formula 13 can be prepared from compounds of Formula 14 byiodination as shown in Scheme 4.

wherein R^(a) are substituents such as R² as defined in Embodiment 3H.

In this method a compound of Formula 14 is contacted with an iodinationreagent such as iodine monochloride in a suitable solvent such as wateror acetic acid. Optionally hydrochloric acid can be included in thereaction mixture to increase the solubility of the compound of Formula14 and the iodine monochloride in the reaction medium. Usually onlyabout one molar equivalent of iodine monochloride is needed tocompletely convert the compound of Formula 14 to the compound of Formula13. Larger molar excesses of iodine monochloride can be used to shortenthe reaction time, but with increased process cost. The reaction can beconducted in a temperature range from about 0 to about 100° C.,typically at temperature of about 50° C. The product of Formula 13 canbe isolated by conventional means, such as filtration, extraction anddistillation.

As illustrated in Scheme 5, compounds of Formula 13a containing at leastone chlorine or bromine moiety can also be prepared by contactingcorresponding compounds of Formula 13 with a suitable chlorinating orbrominating agent such as chlorine, hydrochloric acid/hydrogen peroxide,or hydrobromic acid/hydrogen peroxide.

wherein R^(a) are substituents such as R² as defined in Embodiment 3H;at least one R^(b) is Cl (from chlorination) or Br (from bromination)and the other instances of R^(b) are R^(a) substituents of Formula 13;and p=n+number of chlorine or bromine atoms from chlorination orbromination, respectively.

The reaction is conducted in a solvent such as water or acetic acid. Thetemperature range can be from 0 to 100° C. with a temperature rangebetween 25 and 50° C. preferred.

In another aspect of the present invention, compounds of Formula 1prepared by the method of Scheme 1, are useful for preparing compoundsof Formula 7.

A variety of routes are possible for the preparation of compounds ofFormula 7 from compounds of Formula 1. In one method as shown in Scheme6, a compound of Formula 1 is contacted with hydroxylamine and a base toform a 5-(trifluoromethyl)-4,5-dihydroisoxazole compound of Formula 7.

Hydroxylamine can be generated from a mineral acid salt such ashydroxylamine sulfate or hydroxylamine chloride by treatment with a basein a suitable solvent, or can be obtained commercially as 50% aqueoussolution. In this method before contact with an enone of Formula 1,hydroxylamine or a mineral acid salt thereof is typically contacted witha base. When a mineral acid salt of hydroxylamine is used, the base iscontacted in an amount in excess of the amount needed to convert thehydroxylamine mineral acid salt to hydroxylamine. Base is not consumedin the reaction of Scheme 6, and appears to act as a catalyst for thedesired cyclization. Deprotonation of the hydroxylamine with a baseprior to contact with an enone of Formula 1 is necessary to obtain goodyields, because in the absence of base the reaction of hydroxylaminewith enones can afford products other than compounds of Formula 1.Therefore although often about one molar equivalent of base (in additionto any base used to convert a hydroxylamine mineral acid salt tohydroxylamine) is used relative to hydroxylamine, less than one molarequivalent of base can give excellent results. More than one molarequivalent (e.g., up to about 5 molar equivalents) of base relative tohydroxylamine can be used, provided that the excess base does not reactwith the enone of Formula 1 or the isoxazole of Formula 7.

A molar excess of one to three equivalents of hydroxylamine relative tothe enone of Formula 1 can be used. To ensure the cost-effective,complete, and expeditious conversion of the enone of Formula 1 to theisoxazole of Formula 7, in a manner suitable for large-scale production,between about one and about two molar equivalents of hydroxylaminerelative to the enone of Formula 1 are typically found to be mostsuitable.

Suitable bases can include, but are not limited to, alkali metalalkoxides such as sodium methoxide, alkali metal carbonates such assodium carbonate or potassium carbonate, alkali metal hydroxides such assodium hydroxide and potassium hydroxide, and organic bases. Preferredorganic bases are amine bases having at least one pair of free electronsavailable for protonation such as pyridine, triethylamine orN,N-diisopropylethylamine. Weaker bases such as pyridine can be used,but stronger bases which efficiently deprotonate hydroxylamine, such asan alkali metal alkoxide or an alkali metal hydroxide, typically providebetter results. Because water is an especially useful solvent fordeprotonating hydroxylamine, as well as forming hydroxylamine from itssalts, bases compatible with water are of particular note. Examples ofstrong bases that are soluble and compatible with water are alkali metalhydroxides. Sodium hydroxide is preferred, because it is inexpensive andworks well for deprotonating hydroxylamine, thereby forming the sodiumsalt of hydroxylamine in aqueous solution. Alkali metal alkoxides arefrequently used in solution in a lower alkanol, often the alkanolcorresponding to the alkoxide.

The method of Scheme 6 is conducted in the presence of a suitablesolvent. For best results the solvent should be inert to the base andhydroxylamine, and should be capable of dissolving the enone ofFormula 1. Suitable organic solvents include alcohols, ethers, nitrilesor aromatic hydrocarbons. Water-miscible solvents such as alcohols(e.g., methanol, isopropanol), ethers (e.g., tetrahydrofuran) ornitriles (e.g., acetonitrile) work well with alkali metal hydroxidebases. Solvents which are non-nucleophilic (e.g., ethers and nitriles)often provide the best results. Particularly when a single solvent isused, the most preferred solvents are tetrahydrofuran and acetonitrile.

Alternatively it may be more desirable to conduct the reaction using amixture of two solvents formed by contacting a solution of the enone ofFormula 1 in a solvent such as tetrahydrofuran or acetonitrile with asolution of hydroxylamine and a base such as sodium hydroxide in asecond solvent, which acts as the co-solvent in the solvent mixture.Water is particularly useful as a co-solvent, because mineral acid saltsof hydroxylamine and alkali metal hydroxide bases such as sodiumhydroxide are particularly soluble in water. The rapid generation ofhydroxylamine from its mineral acid salt and subsequent deprotonation ofhydroxylamine facilitated by water, and the solubility and stability ofthe deprotonated species in water are especially desirable. Inlarge-scale production, solutions rather than slurries are preferred,because they are easier to handle and transfer in process equipment.When water is the co-solvent, the other solvent is typically awater-miscible solvent such as tetrahydrofuran or acetonitrile.

Other highly polar, hydroxylic solvents such as lower alkanols (e.g.,methanol, ethanol) are also particularly useful as co-solvents, becauselike water they readily dissolve mineral acid salts of hydroxylamine andalkali metal hydroxides. Lower alkanols can give better results thanwater as a co-solvent when the other solvent is not water-miscible,e.g., tert-butyl methyl ether. When a lower alkanol is used as aco-solvent, particularly with another solvent that is notwater-miscible, the base added is often an alkali metal alkoxide insteadof an alkali metal hydroxide.

As long as base is present to deprotonate hydroxylamine, thehydroxylamine, the base and the enone of Formula 1 can be contacted in avariety of ways in the method of Scheme 6. For example, a mixture formedfrom hydroxylamine and the base (typically in a solvent such as water)can be added to the enone of Formula 1 (typically in a solvent such astetrahydrofuran or acetonitrile). Alternatively, the hydroxylamine andthe base can be concurrently added separately to the enone of Formula 1.In another embodiment, the enone of Formula 1 (typically in a solventsuch as tetrahydrofuran or acetonitrile) can be added to a mixtureformed from the hydroxylamine and the base (typically in a solvent suchas water). In these example embodiments other combinations of solventscan be used; for example, methanol with tert-butyl methyl ether insteadof water with tetrahydrofuran or acetonitrile.

The method of Scheme 6 can be conducted at a reaction temperaturebetween about 0 and 150° C., or most conveniently between 20 and 40° C.The product of Formula 7 is isolated by the usual methods known to thoseskilled in the art including extraction and crystallization.

Compounds of Formulae 7a, 7b and 7c are subsets of compounds of Formula7 that are of particular note as insecticides.

wherein R², R³, R⁴, R⁵ and R^(v) are as defined in the Summary of theInvention, Exhibit 1 and the Embodiments, and n is an integer from 0 to5.

Therefore for preparation of compounds of Formulae 7a, 7b and 7c ofparticular note are embodiments of the method of Scheme 6 shown inScheme 7 wherein the compound of Formula 1 is prepared by the method ofScheme 1.

Compounds of Formula 7 can often be prepared from other compounds ofFormula 7 by modification of substituents. For example, compounds ofFormula 7a can be prepared by aminocarbonylation of compounds of Formula7d with appropriately substituted amine compounds of Formula 15 as shownin Scheme 8.

This reaction is typically carried out with an aryl bromide of Formula7d in the presence of a palladium catalyst under a CO atmosphere. Thepalladium catalysts used for this method typically comprises palladiumin a formal oxidation state of either 0 (i.e. Pd(0)) or 2 (i.e. Pd(II)).A wide variety of such palladium-containing compounds and complexes areuseful as catalysts for this method. Examples of palladium-containingcompounds and complexes useful as catalysts in the method of Scheme 8include PdCl₂(PPh₃)₂ (bis(triphenylphosphine)palladium(II) dichloride),Pd(PPh₃)₄ (tetrakis(triphenylphosphine)-palladium(0)), Pd(C₅H₇O₂)₂(palladium(II) acetylacetonate), Pd₂(dba)₃(tris(dibenzylidene-acetone)dipalladium(0)), and[1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The methodof Scheme 8 is generally conducted in a liquid phase, and therefore tobe most effective the palladium catalyst preferably has good solubilityin the liquid phase. Useful solvents include, for example, ethers suchas 1,2-dimethoxyethane, amides such as N,N-dimethylacetamide, andnon-halogenated aromatic hydrocarbons such as toluene.

The method of Scheme 8 can be conducted over a wide range oftemperatures, ranging from about 25 to about 150° C. Of note aretemperatures from about 60 to about 110° C., which typically providefast reaction rates and high product yields. The general methods andprocedures for aminocarbonylation with an aryl bromide and an amine arewell known in the literature; see, for example, H. Horino et al.,Synthesis 1989, 715; and J. J. Li, G. W. Gribble, editors, Palladium inHeterocyclic Chemistry: A Guide for the Synthetic Chemist, 2000.

Compounds of Formula 7d can be prepared by the method of Scheme 6 fromcompounds of Formula 1, which are prepared by the method of Scheme 1according to the present invention.

Compounds of Formula 7a can also be prepared by coupling a carboxylicacid compound of Formula 7e with an appropriately substituted aminocompound of Formula 15 as shown in Scheme 9.

This reaction is generally carried out in the presence of a dehydratingcoupling reagent such as dicyclohexylcarbodiimide,1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-propanephosphonic acidcyclic anhydride or carbonyl diimidazole in the presence of a base suchas triethylamine, pyridine, 4-(dimethylamino)pyridine orN,N-diisopropylethylamine in an anhydrous aprotic solvent such asdichloromethane or tetrahydrofuran at a temperature typically betweenabout 20 and about 70° C.

Compounds of Formula 7e can be prepared by the method of Scheme 6 fromcompounds of Formula 1, which are prepared by the method of Scheme 1according to the present invention. Alternatively, compounds of Formula7e can be prepared by hydrolyzing ester compounds of Formula 7f as shownin Scheme 10.

wherein R^(5a) is, for example, methyl or ethyl.

In this method, an ester of Formula 7f is converted to a correspondingcarboxylic acid of Formula 7e by general procedures well known in theart. For example, treatment of a methyl or ethyl ester of Formula 7fwith aqueous lithium hydroxide in tetrahydrofuran, followed byacidification yields the corresponding carboxylic acid of Formula 7e.

Compounds of Formula 7f can be prepared by the method of Scheme 6 fromcompounds of Formula 1, which are prepared by the method of Scheme 1according to the present invention.

Without further elaboration, it is believed that one skilled in the artusing the preceding description can utilize the present invention to itsfullest extent. The following Examples are, therefore, to be construedas merely illustrative, and not limiting of the disclosure in any waywhatsoever. Steps in the following Examples illustrate a procedure foreach step in an overall synthetic transformation, and the startingmaterial for each step may not have necessarily been prepared by aparticular preparative run whose procedure is described in otherExamples or Steps. Percentages are by weight except for chromatographicsolvent mixtures or where otherwise indicated. Parts and percentages forchromatographic solvent mixtures are by volume unless otherwiseindicated. ¹H NMR spectra are reported in ppm downfield fromtetramethylsilane; “s” means singlet, “d” means doublet, “t” meanstriplet, “q” means quartet, “m” means multiplet, “dd” means doublet ofdoublets, “dt” means doublet of triplets and “br” means broad.

EXAMPLE 1 Preparation of methyl4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-1-naphthalenecarboxylateStep A: Preparation of methyl4-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-1-naphthalenecarboxylate

A mixture of methyl 4-acetyl-1-naphthalenecarboxylate (5.36 g, 23.4mmol), dichlorophenyl)-2,2,2-trifluoroethanone (5.68 g, 23.4 mmol),calcium hydroxide (0.172 g, 2.3 mmol), N,N-dimethylformamide (16 mL),and tert-butyl methyl ether (32 mL) was placed in a thermometer-equippedreaction vessel. The reaction vessel was connected to a ten-plateOldershaw column, the output of which was condensed and fed into adecanter initially filled with tert-butyl methyl ether. A nitrogenatmosphere was maintained in the apparatus. The upper part of thedecanter was connected to return condensate to the fifth plate of theOldershaw column. This arrangement ensured that wet (containingdissolved water) tert-butyl methyl ether from the decanter was notreturned to the reaction vessel. A drain valve at the bottom of thedecanter allowed removing tert-butyl methyl ether in addition to waterfrom the decanter. The reaction mixture was heated to distill thetert-butyl methyl ether/water azeotrope. As the decanter trap containedan amount of tert-butyl methyl ether sufficient to dissolve all of thewater formed by the reaction, the condensate in the trap did notseparate into layers containing predominately water and predominatelytert-butyl methyl ether. Because the reaction mixture initiallycontained mostly tert-butyl methyl ether, the mixture boiled at atemperature not much exceeding the normal boiling point of tert-butylmethyl ether (e.g., about 65-70° C.). The reaction appeared to proceedrelatively slowly at this temperature, so condensate was graduallydrained from the decanter trap to remove tert-butyl methyl ether. As theconcentration of tert-butyl methyl decreased in the reaction mixture,the temperature of the boiling mixture increased. Tert-butyl methylether was removed by draining the decanter until the temperature of theboiling reaction mixture reached about 75 to 80° C. To maintain thistemperature range, tert-butyl methyl ether was added as needed tocompensate for loss of solvent from the apparatus. The total time frombeginning heating the reaction mixture to stopping distillation, notincluding a shutdown period overnight, was about 15 h. During this timeperiod a further portion of calcium hydroxide (1.34 g, 18.1 mmol) wasadded to increase the reaction rate.

To isolate the product, the mixture was cooled to room temperature andfiltered. The collected solid was washed with tert-butyl methyl ether(10 mL). Water (100 mL) was added, and the aqueous layer was acidifiedwith hydrochloric acid. The organic phase was washed with water (100mL), dried, and evaporated to give the product as a yellow solid (10.1g, 95% yield) melting at 91-91.5° C. (after recrystallization fromhexanes). The following spectra were of the product recrystallized fromhexanes.

IR (nujol) 1723, 1670, 1560, 1280, 1257, 1230, 1186, 1171, 1132, 1098,1022, 804 cm⁻¹. ¹H NMR (CDCl₃) 8.78-8.76 (m, 1H), 8.32-8.30 (m, 1H) 8.02(d, J=7.6 Hz, 1H) 7.65-7.62 (m, 3H), 7.34 (s, 1H), 7.07-7.06 (m, 1H),6.94 (d, J=1.7 Hz, 2H), 4.03 (s, 3H).

Step B: Preparation of methyl4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazo-1-naphthalenecarboxylate

Sodium hydroxide (50%, 3.50 g, 43.7 mmol) was added to a solution ofhydroxylamine sulfate (1.8 g, 11.0 mmol) in water (22 mL). When themixture had cooled to room temperature a portion of the mixture (-50%)was added dropwise over 4 minutes to methyl4-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-1-naphthalene-carboxylate(i.e. the product of Step A) (5.00 g, 11.0 mmol) in tetrahydrofuran (55mL) at room temperature. After 30 minutes a further portion (˜10%) ofthe aqueous mixture was added. The mixture was stirred for a further 15minutes. The mixture was partitioned between hydrochloric acid (1 N, 50mL) and tert-butyl methyl ether (50 mL). The organic phase wasevaporated, and the solid obtained was stirred in hot methanol. Themixture was cooled and filtered to give the product as a white solid(4.50 g, 87%) melting at 137.3-138° C. (after recrystallization frommethanol). The following spectra were of the product recrystallized frommethanol.

IR(nujol) 1716, 1569, 1518, 1433, 1332, 1309, 1288, 1251, 1192, 1167,1139, 1114, 1102, 1027, 1006, 910, 867, 855 cm⁻¹.

¹H NMR (CDCl₃) 8.89-8.87 (m, 1H), 8.80-8.78 (m, 1H), 8.10 (d, J=7.6 Hz,1H), 7.69-7.66 (m, 2H), 7.56-7.53 (m, 3H), 7.46 (t, J=2 Hz, 1H), 4.27(1/2ABq, J=17 Hz, 1H), 4.03 (s, 3H), 3.91 (1/2ABq, J=17 Hz, 1H).

EXAMPLE 2 Preparation of methyl4-[5-[3,5-bis(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-1-naphthalenecarboxylateStep A: Preparation of methyl4-[3-[3,5-bis(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-1-naphthalenecarboxylate

A mixture of methyl 4-acetyl-1-naphthalenecarboxylate (5.36 g, 23.5mmol), 1-[3,5-bis(trifluoromethyl)phenyl]-2,2,2-trifluoroethanone (7.28g, 23.5 mmol), calcium hydroxide (1.40 g, 18.9 mmol),N,N-dimethylformamide (16 mL) and tert-butyl methyl ether (32 mL) wasboiled with provision of the apparatus comprising a ten-plate Oldershawcolumn and decanter described in Example 1, Step A for removal of thetert-butyl methyl ether/water azeotrope. As the decanter trap containedan amount of tert-butyl methyl ether sufficient to dissolve all of thewater formed by the reaction, the condensate in the trap did notseparate into layers containing predominately water and predominatelytert-butyl methyl ether. Tert-butyl methyl ether was removed bygradually draining the decanter trap until the pot temperature was 85°C. To maintain this temperature, tert-butyl methyl ether was added asneeded to compensate for loss of solvent from the apparatus. The totaltime from beginning heating the reaction mixture to stoppingdistillation, not including a shutdown period overnight, was about 10 h.During this time period no additional calcium hydroxide was added to thereaction mixture.

To isolate the product, the mixture was cooled to room temperature andwas filtered. The solid was washed with tert-butyl methyl ether and thefiltrate was washed with water (30 mL), and diluted with tert-butylether. The mixture was evaporated to give the product as a yellow solid(12.1 g, 99%) melting at 91.5-92° C. (after recrystallization fromhexanes). The following spectra were of the product recrystallized fromhexanes.

IR (nujol) 1720, 1685, 1515, 1441, 1405, 1345, 1280, 1261, 1187, 1171,1147, 1129, 1097, 1024, 899, 856 cm⁻¹.

¹H NMR (CDCl₃) 8.74-8.72 (m, 1H), 8.23-8.21 (m, 1H) 7.99 (d, J=7.3 Hz,1H), 7.67 (d, J=7.6 Hz, 1H), 7.64-7.57 (m, 3H), 7.51 (s, 2H), 7.47 (d,J=1.4 Hz, 1H), 4.04 (s, 3H).

Step B: Preparation of methyl4-[5-[3,5-bis(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-1-naphthalenecarboxylate

Sodium hydroxide (50%, 1.53 g, 38.2 mmol) was added to hydroxylaminesulfate (1.57 g, 9.57 mmol) in water (18 mL). A portion of the solution(˜51%, ˜9.8 mmol of hydroxyl amine) was added dropwise to methyl4-[3-[3,5-bis(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-1-naphthalenecarboxylate(i.e. the product of Step A) (5.00 g, 9.61 mmol) in tetrahydrofuran (45mL). After ˜45 min the mixture was poured into hydrochloric acid (1 N,100 mL) and was extracted with ether (3×80 mL).

The combined organic extracts were washed with water (80 mL), dried andevaporated. The material was stirred in hot methanol, then cooled toroom temperature, collected under filtration and dried in vacuum to givethe product as a white solid (4.14 g, 80% yield) melting at 130-131° C.(after recrystallization from methanol). The following spectra were ofthe product recrystallized from methanol.

IR (nujol) 1722, 1515, 1437, 1330, 1284, 1208, 1193, 1174, 1128, 1106,1025, 1009, 916, 903, 859, 842 cm⁻¹.

¹H NMR (CDCl₃) 8.89-8.87 (m, 1H), 8.82-8.79 (m, 1H), 8.14-8.09 (m, 3H),8.0 (s, 1H), 7.70-7.67 (m, 2H), 7.56 (d, J=7.6 Hz, 1H), 4.39 (1/2 ABq,J=17.3 Hz, 1H), 4.03 (s, 3H), 3.96 (1/2 ABq, J=17.6 Hz, 1H).

EXAMPLE 3 Alternative preparation of methyl4-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-1-naphthalenecarboxylate

A solution of 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone (1.42 g,5.84 mmol) in N,N-dimethylformamide (5.5 mL) was added to calciumhydride (0.280 g, 6.66 mmol). A solution of methyl4-acetyl-1-naphthalenecarboxylate (1.34 g, 5.88 mmol) inN,N-dimethylformamide (5.5 mL) was added to the mixture. The mixture waswarmed to 45-50° C. for 8 h. The mixture was cooled to room temperatureovernight. After a further 4 h at 60° C. the mixture was cooled to roomtemperature and was added dropwise to hydrochloric acid (1 N, 100 mL).The mixture was extracted with ethyl acetate (2×100 mL), and thecombined extracts were dried and evaporated to give the product (2.7 g,102% yield), which contained a little N,N-dimethylformamide. The ¹H NMRspectrum of the major isomer was recorded as follows.

¹H NMR (CDCl₃) 8.78-8.75 (m, 1H), 8.33-8.30 (m, 1H), 8.02 (d, J=7.7 Hz,1H), 7.66-7.61 (m, 3H), 7.34 (s, 1H), 7.07-7.04 (m, 1H), 6.94 (d, J=2Hz, 2H) 4.03 (s, 3H).

EXAMPLE 4 Preparation of 2-chloro-6-iodo-4-(trifluoromethyl)benzenamine

Iodine monochloride (17.2 g, 108 mmol) in hydrochloric acid (36%, 21.4g) and water (35 mL) was added dropwise to2-chloro-4-(trifluoromethyl)benzenamine (20.0 g, 102 mmol) inhydrochloric acid (36%, 20.7 g) and water (140 mL). The mixture waswarmed to 50° C. for a total of 8 h. Sodium hydroxide (50%, 33.5 g, 419mmol) was added to the mixture at room temperature. The mixture wasextracted with dichloromethane (2×250 mL), and the extracts were driedand evaporated to give the product as an oil (31.83 g, 97% yield).

¹H NMR (CDCl₃) 7.78 (s, 1H), 7.5 (s, 1H), 4.87 (br s, 2H).

EXAMPLE 5 Preparation of 1-chloro-3-iodo-5-(trifluoromethyl)benzene

2-Chloro-6-iodo-4-(trifluoromethyl)benzenamine (i.e. the product ofExample 4) (31.8 g, 98.9 mmol) was added to hydrochloric acid (36%, 190mL) and the mixture was warmed to 55-60° C. for 20 min. The mixture wascooled to 0° C. Sodium nitrite (13.6 g, 197 mmol) in water (36 mL) wasadded over 30 min. When the addition was complete the mixture wasstirred at 0-5° C. for 70 min. Hypophosphorous acid (50%, 36.5 mL, 351mmol) was added dropwise at 5-10° C. over 40 min. When the addition wascomplete the mixture spontaneously warmed briefly to 35° C., and wasthen cooled to 10-20° C. After stirring at 10-20° C. for 2 h, themixture was stored in a refrigerator overnight. Then thee mixture waswarmed to room temperature and was stirred for 1 h. The mixture wasdiluted with water (400 mL) and extracted with ether (2×250 mL). Thecombined extracts were dried and evaporated. Distillation gave theproduct as an oil (19.93 g, 66% yield), b.p. 98-112° C. at 2.0 kPa.

¹H NMR (CDCl₃) 7.89 (s, 1H), 7.84 (s, 1H), 7.58 (s, 1H).

EXAMPLE 6 Preparation of1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethanone

A tetrahydrofuran solution of isopropylmagnesium chloride (2 M, 36.0 mL,71.8 mmol) was added dropwise to a solution of1-chloro-3-iodo-5-(trifluoromethyl)benzene (i.e. the product of Example5) (20.0 g, 65.3 mmol) in tetrahydrofuran (30 mL) at −5° C. The mixturewas stirred for 1 h at 0-5° C. Methyl trifluoroacetate (10.0 g, 78.1mmol) was added dropwise to the mixture while maintaining thetemperature 0-5° C. When the addition was complete the mixture wasstirred for 90 min.

Hydrochloric acid (1 N, 100 mL) was added dropwise to the mixture at0-5° C. When the addition was complete the mixture was extracted withether (2×100 mL).

The combined extracts were dried and evaporated. The oil was dissolvedin toluene (55 mL), and p-toluenesulfonic acid monohydrate (0.100 g,0.525 mmol) was added to the mixture. The mixture was boiled for 30 min,and the water/toluene methanol/toluene azeotropes were removed bydistillation at atmospheric pressure. The distillation was continued atreduced pressure to give the product as an oil (12.4 g, 69% yield), b.p.93-103° C. at 6.7 kPa.

¹H NMR (CDCl₃) 8.21-8.19 (m, 2H), 7.95 (s, 1H).

EXAMPLE 7 Preparation of4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamideStep A: Preparation of 4-acetyl-1-naphthalenecarbonyl chloride

Thionyl chloride (35.00 g, 0.29 mol) was added to a solution of4-acetyl-1-naphthalenecarboxylic acid (51.70 g, 0.24 mol) in toluene(350 mL). The mixture was warmed to 90° C. for 8.5 h. After cooling to25° C., the solvent was removed under reduced pressure to give the titleproduct as an off-white solid (55.1 g, 98.7% yield).

IR (nujol) 1758, 1681, 1515, 1352, 1282, 1245,1218, 1190, 1117, 1053,923, 762 cm⁻¹.

¹H NMR (CDCl₃): 8.72-8.69 (m, 1H), 8.50 (d, J=7.6 Hz, 1H), 8.44-8.41 (m,1H), 7.82 (d, J=7.9 Hz, 1H), 7.76-7.65 (m, 2H), 2.77 (s, 3H).

Step B: Preparation of4-acetyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

A solution of 2-amino-N-(2,2,2-trifluoroethyl)acetamide (21.90 g, 0.14mol) in 1,2-dichloroethane (80 mL) was added dropwise over 15 min to asolution of the product of Example 7, Step A (32.50 g, 0.14 mol) in1,2-dichloroethane (160 mL) at a temperature of 25 to 30° C. Theresulting mixture was further stirred for 10 min at 25° C. A solution oftriethylamine (14.20 g, 0.14 mol) in 1,2-dichloroethane (80 mL) was thenadded dropwise over 44 min at 25° C., and the mixture was stirredfurther for 20 min at 25° C. The solvent was removed under reducedpressure, and the residue was dissolved in hot acetonitrile (50 mL). Themixture was then cooled to 25° C., and water (40 mL) was added dropwise.The mixture was further cooled to 0° C. and filtered. The isolated solidwas washed with water (100 mL) and dried overnight in a vacuum oven(approximately 16-33 kPa at 50° C.) to provide the title product as anoff-white solid (37 g, 75% yield) melting at 169-169° C.

IR (nujol) 3303, 3233, 3072, 1698, 1683, 1636, 1572, 1548, 1447, 1279,1241, 1186, 1159 cm⁻¹.

¹H NMR (CD₃S(═O)CD₃): 8.95 (t, J=5.8 Hz, 1H), 8.72 (t, J=6.5 Hz, 1H),8.55 (dd, J=6.5, 2 Hz, 1H), 8.37-8.33 (m, 1H), 8.13 (d, J=7.3 Hz, 1H),7.70-7.60 (m, 3H), 4.07-3.95 (m, 4H), 2.75 (s, 3H).

Step C: Preparation of4-[3-[3-chloro-5-(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

A mixture of the product of Example 7, Step B (10.00 g, 28.38 mmol),1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethanone (9.00 g,32.5 mmol), calcium hydroxide (1.05 g, 14.2 mmol), N,N-dimethylformamide(20 mL) and tert-butyl methyl ether (32 mL) was placed in athermometer-equipped reaction vessel. The reaction vessel was connectedto a ten-plate Oldershaw column, the output of which was condensed andfed into a decanter initially filled with tert-butyl methyl ether. Anitrogen atmosphere was maintained in the apparatus. The upper part ofthe decanter was connected to return condensate to the fifth plate ofthe Oldershaw column. This arrangement ensured that wet (containingdissolved water) tert-butyl methyl ether was not returned from thedecanter to the reaction vessel. A drain valve at the bottom of thedecanter allowed removing tert-butyl methyl ether in addition to waterfrom the decanter. The reaction mixture was heated to distill thetert-butyl methyl ether/water azeotrope. As the decanter trap containedan amount of tert-butyl methyl ether sufficient to dissolve all of thewater formed by the reaction, the condensate in the trap did notseparate into layers containing predominately water and predominatelytert-butyl methyl ether. Because the reaction mixture initiallycontained mostly tert-butyl methyl ether, the mixture boiled at atemperature not much exceeding the normal boiling point of tert-butylmethyl ether (e.g., about 65-70° C.). The reaction proceeded relativelyslowly at this temperature, so condensate was gradually drained from thedecanter trap to remove tert-butyl methyl ether. As the concentration oftert-butyl methyl ether decreased in the reaction mixture, thetemperature of the boiling reaction mixture increased. Tert-butyl methylether was removed by draining the decanter until the temperature of theboiling reaction mixture reached about 85° C. To maintain thistemperature, tert-butyl methyl ether was added as needed to compensatefor loss of solvent from the apparatus. The total time from the start ofheating the reaction mixture to stopping distillation, not including ashutdown period overnight, was about 6 h.

To isolate the product, the mixture was cooled to room temperature andthen added to a mixture of tert-butyl methyl ether (50 mL) and 1 Nhydrochloric acid (100 mL). The organic phase was separated, and heptane(60 mL) was added dropwise. The mixture was filtered to provide thetitle product as an off-white solid mixture of isomers (14 g, 81% yield)melting at 174.5-177° C.

IR (nujol) 3294, 1697, 1674, 1641, 1541, 1441, 1364, 1313, 1275, 1246,1163, 1104 cm⁻¹.

¹H NMR (CD₃S(═O)CD₃): (major isomer) 8.91 (t , J=6.2 Hz, 1H), 8.73 (t,J=6.4 Hz, 1H), 8.44-8.30 (m, 2H), 8.18 (d, J=7.7 Hz, 1H), 7.97-7.61 (m,7H), 4.06-3.95 (m, 4H).

Step D: Preparation of4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

Aqueous sodium hydroxide (50%, 3.04 g, 38.0 mmol) was added dropwise toa stirred solution of hydroxylamine sulfate (1.48 g, 9.02 mmol) in water(28 mL) at 25° C. After this addition was complete the product ofExample 7, Step C (10.00 g, 16.33 mmol) in tetrahydrofuran (60 mL) wasadded dropwise over 40 min. After the addition was complete the mixturewas stirred further for 30 min. The solvent was removed under reducedpressure and 1 N hydrochloric acid (100 mL) was added. The mixture wasextracted with ether (2×100 mL), and the combined extracts were driedand evaporated. The residue was dissolved in acetonitrile (30 mL),cooled to 0° C., and filtered to afford the title product as a whitesolid (7.84 g, 77% yield) melting at 107-108.5° C. (afterrecrystallisation from acetonitrile).

IR (nujol) 3312, 1681, 1642, 1536, 1328, 1304, 1271, 1237, 1173, 1116cm⁻¹.

¹H NMR (CD₃S(═O)CD₃): 8.98 (t, J=5.8 Hz, 1H), 8.82 (d, J=7.4 Hz, 1H),8.74 (t, J=6.5 Hz, 1H), 8.40 (d, J=9.7 Hz, 1H), 8.09 (d, J=15.3 Hz, 2H),7.93 (d, J=7.6 Hz, 2H), 7.75-7.04 (m, 3H), 4.63 (s, 2H), 4.07-3.96 (4H,m).

EXAMPLE 7A Alternative Preparation of4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamideStep A: Preparation of4-[3-[3-chloro-5-(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

A mixture of4-acetyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide(100.00 g, 267.23 mmol),1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethanone (86.92 g,288.6 mmol) and acetonitrile (500 mL) was placed in athermometer-equipped reaction vessel. The reaction vessel was connectedto a ten-plate Oldershaw column. A nitrogen atmosphere was maintained inthe apparatus. The mixture was heated to boiling, at which time thetemperature of the top of the column was 82° C. Potassium carbonate wasadded to the reaction mixture portionwise to control the rate ofreaction. Initially, 0.40 g of potassium carbonate was added, followedsequentially by individual 0.1 g additions 30, 60, 120 and 180 minutes,and 0.40 g additions 240 and 300 minutes after the initial addition ofpotassium carbonate. Prior to addition to the reaction mixture, thepotassium carbonate was slurried in a small amount of acetonitrile(approximately 3 mL of acetonitrile was used to slurry the 0.40 gquantities of potassium carbonate, and approximately 2 mL ofacetonitrile was used to slurry the 0.1 g quantities of potassiumcarbonate). The acetonitrile/water azeotrope (bp 76.5° C.) wascontinuously removed from the top of the column as it was formed. Afterthe final potassium carbonate addition the mixture was boiled for afurther 60 minutes. After a total time of 6 h from the initial additionof potassium carbonate, more acetonitrile was removed by distillationuntil a total of 265 mL of acetonitrile and acetonitrile/water azeotropehad been removed. The mixture was cooled to 25° C., and water (48 mL)was added to the mixture. The mixture was cooled to 0° C. over 30minutes, held at this temperature for 60 minutes, and then filtered. Theisolated solid was washed with acetonitrile:water (96 mL, 26:5acetonitrile:water).

The product was dried in a vacuum oven (approximately 16-33 kPa at 55°C.) overnight to give the product as an off-white solid (150.51 g as amixture of isomers, 92.2% yield).

The ¹H NMR spectrum of the major isomer was identical to the spectrum ofthe material prepared in Example 7, Step C.

Step B: Preparation of4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

A solution of sodium hydroxide (15.10 g of a 50% aqueous solution, 0.19mmol) in water (total volume 67.5 mL) and a solution of hydroxylaminesulfate (7.75 g, 47.3 mmol) in water (total volume 67.5 mL) were addedsimultaneously to the product of Example 7A, Step A (51.90 g, 81.78mmol) in tetrahydrofuran (300 mL) at 25° C. over 75 minutes. After theaddition was complete, the mixture was stirred further for 180 minutes.The mixture was acidified to approximately pH 3 by addition ofhydrochloric acid (concentrated, approximately 11 g). The aqueous layerwas removed, and the remaining organic solution was heated to boiling.Acetonitrile was added, and the acetonitrile/tetrahydrofuran distillatewas removed until the distillate temperature reached 82° C., indicatingthat all of the tetrahydrofuran had been removed. The mixture wasallowed to cool to 25° C., and the acetonitrile was removed underreduced pressure. The residue was dissolved in acetonitrile (200 mL),cooled to 0° C., and the resulting mixture was filtered to afford thetitle product as a white solid (43.45 g, 84% yield).

The ¹H NMR spectrum of the product was identical to the spectrum of thematerial prepared in Example 7, Step D.

EXAMPLE 7B Alternative Preparation of4-[3-[3-chloro-5-(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

A mixture of4-acetyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide(50.00 g, 135.1 mmol),1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethanone (43.93 g,145.8 mmol) and acetonitrile (250 mL) was placed in athermometer-equipped reaction vessel. The reaction vessel was connectedto a ten-plate Oldershaw column. A nitrogen atmosphere was maintained inthe apparatus. The mixture was heated to boiling, at which time thetemperature of the top of the column was 82° C.1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) was added to the reactionmixture portionwise to control the rate of reaction. Initially, 0.20 gof DBU was added, followed sequentially by individual 0.052 g additions30, 90, 150 and 210 minutes, and 0.20 g additions 270 and 330 minutesafter the initial addition of DBU. Each individual DBU portion wasdiluted with acetonitrile (2 mL) prior to addition to the reactionmixture. The acetonitrile/water azeotrope (bp 76.5° C.) was continouslyremoved from the top of the column as it was formed. After the final DBUaddition the mixture was boiled for a further 60 minutes. After a totaltime of 6 h from the initial addition of DBU, more acetonitrile wasremoved by distillation until a total of 138 mL of acetonitrile andacetonitrile/water azeotrope had been removed. The mixture was cooled to25° C., and water (24 mL) was added to the mixture. The mixture wascooled to 0° C. over 30 minutes, held at this temperature for 60minutes, and then filtered. The isolated solid was washed withacetonitrile:water (48 mL, 26:5 acetonitrile:water).

The product was dried in a vacuum oven (approximately 16-33 kPa at 55°C.) overnight to give the product as an off-white solid (76.0 g as amixture of isomers, 92.0% yield).

The ¹H NMR spectrum of the major isomer was identical to the spectrum ofthe material prepared in Example 7, Step C.

EXAMPLE 8 Preparation of methyl4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-1-naphthalenecarboxylateStep A: Preparation of methyl4-[3-[3-chloro-5-(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-1-naphthalenecarboxylate

A mixture of methyl 4-acetyl-1-naphthalenecarboxylate (7.83 g, 34.3mmol), 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethanone(10.43 g, 37.71 mmol), calcium hydroxide (1.25 g, 16.9 mmol),N,N-dimethylformamide (27 mL) and tert-butyl methyl ether (44 mL) washeated to reflux. The tert-butyl methyl ether/water azeotrope wasremoved as described in Example 7, Step C. As the decanter trapcontained an amount of tert-butyl methyl ether sufficient to dissolveall of the water formed by the reaction, the condensate in the trap didnot separate into layers containing predominately water andpredominately tert-butyl methyl ether. Tert-butyl methyl ether wasremoved by gradually draining the decanter trap until the reactiontemperature was 85° C. To maintain this temperature, tert-butyl methylether was added as needed to compensate for loss of solvent from theapparatus. The total time from the start of heating the reaction mixtureto stopping distillation was about 4.5 h.

The mixture was cooled to 25° C. and poured into a mixture of 0.5 Nhydrochloric acid (100 mL) and tert-butyl methyl ether (50 mL). Themixture was acidified with concentrated hydrochloric acid andevaporated, and the residue was crystallized from hexanes (40 mL) togive the title product as a yellow solid (13.24 g, 79% yield) melting at90-90.5° C. (after recrystallization from hexanes).

IR (nujol) 3071, 1721, 1710, 1671, 1516, 1439, 1316, 1280, 1252, 1178,1129, 1103, 1026, 888, 861 cm⁻¹.

¹H NMR (CDCl₃): 8.77-8.73 (m, 1H), 8.28-8.25 (m, 1H), 8.0 (d, J=7.6 Hz,1H), 7.67-7.60 (m, 3H), 7.40 (d, J=1.4 Hz, 1H), 7.32 (s, 1H), 7.23 (s,1H), 7.20 (s, 1H), 4.02 (s, 3H).

Step B: Preparation of methyl4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-1-naphthalenecarboxylate

Aqueous sodium hydroxide (50%, 2.08 g, 25.5 mmol) was added dropwise toa stirred solution of hydroxylamine sulfate (1.07 g, 6.52 mmol) in water(20 mL) at 25° C. After this addition was complete the product ofExample 8, Step A (5 g, 10.27 mmol) in tetrahydrofuran (20 mL) was addeddropwise over 40 min. After the addition was complete the mixture wasstirred further for 30 min. The organic phase was separated and added tohydrochloric acid (100 mL). The mixture was extracted with ethyl acetate(2×20 mL). The organic solvent was evaporated under reduced pressure.The residue was redissolved in acetic acid (16 mL) and then warmed to100° C. Water (2 mL) was added dropwise, and the mixture was cooled to50° C. The mixture was seeded with a small amount of previously preparedmethyl4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-1-naphthalenecarboxylateand then cooled to 25° C. Water (2 mL) was added and the mixture wascooled to 0° C. The mixture was filtered, and the solid was washed withacetic acid:water (8 mL:2 mL). The solid was dried in a vacuum oven togive the title product as a white solid (3.91 g, 76% yield) melting at111.5-112° C. (after recrystallisation from acetonitrile).

IR (nujol) 1716, 1328, 1306, 1287, 1253, 1242, 1197, 1173, 1137, 1114,1028, 771 cm⁻¹.

¹H NMR (CDCl₃): 8.90-8.87 (m, 1H), 8.82-8.79 (m, 1H), 8.10 (d, J=7.7Hz), 7.87 (s, 1H), 7.81 (s, 1H), 7.72-7.67 (m, 3H) 7.55 (d, J=7.6 Hz,1H), 4.34 (1/2 ABq, J=17.3 Hz, 1H), 4.03 (s, 3H), 3.93 (1/2 ABq, J=17.3Hz, 1H).

The following Tables 1-8 identify specific combinations of reactants,intermediates and products illustrating the methods of the presentinvention. These tables specifically disclose compounds as well asparticular transformations. In these tables: Et means ethyl, Me meansmethyl, CN means cyano, Ph means phenyl, Py means pyridinyl, c-Pr meanscyclopropyl, i-Pr means isopropyl, n-Pr means normal propyl, s-Bu meanssecondary butyl, t-Bu means tertiary butyl, SMe means methylthio, S(O)₂means sulfonyl and Thz means thiazole. Concatenations of groups areabbreviated similarly; for example, “S(O)₂Me” means methylsulfonyl.

Tables 1-6 relate to the method of Scheme 1 converting compounds ofFormulae 2 and 3 to corresponding compounds of Formula 1. Thistransformation is believed to occur through the intermediacy ofcompounds of Formula 11.

In the example transformations embodied in Tables 1-6, M is Ca, andwater is distilled as an azeotrope from a reaction mixture comprisingN,N-dimethylformamide as the polar aprotic solvent and text-butyl methylether as the aprotic solvent capable of forming a low-boiling azeotropewith water.

TABLE 1

R^(2a) R^(2b) R^(2c) R⁵ Cl H Cl CH₂CH₃ Cl H Cl CH₂—i-Pr Cl H Cl CH₂CH₂ClCl H Cl CH₂CH₂OH Cl H Cl CH(Me)CH₂OH Cl H Cl CH₂CH(Me)OH Cl H ClCH₂C(Me)₂OH Cl H Cl CH₂CH₂CH₂OH Cl H Cl CH₂C(Me)₂CH₂OH Cl H ClCH₂CH₂CH(Me)OH Cl H Cl CH₂C(═O)N(H)Et Cl H Cl CH₂C(═O)N(H)—i-Pr Cl H ClCH₂C(═O)N(H)CH₂—i-Pr Cl H Cl CH(Me)C(═O)N(H)CH₂—i-Pr Cl H ClCH₂C(═O)N(H)CH₂CH₂Cl Cl H Cl CH(Me)C(═O)N(H)CH₂CH₂Cl Cl H ClCH₂C(═O)N(H)CH₂CH₂F Cl H Cl CH(Me)C(═O)N(H)CH₂CH₂F Cl H Cl CH₂CF₃ Cl HCl CH₂—(2-Py) Cl H Cl CH₂—(4-Thz) Cl H Cl CH₂—c-Pr Cl H Cl CH₂CH₂SMe ClH Cl CH(Me)CH₂SMe Cl H Cl CH₂CH₂CH₂SMe Cl H Cl CH₂CH₂S(═O)Me Cl H ClCH(Me)CH₂S(═O)Me Cl H Cl CH₂CH₂CH₂S(═O)Me Cl H Cl CH₂CH₂S(O)₂Me Cl H ClCH(Me)CH₂S(O)₂Me Cl H Cl CH₂CH₂CH₂S(O)₂Me Cl H Cl CH₂C(═O)N(H)CH₂CF₃ ClH Cl CH(Me)C(═O)N(H)CH₂CF₃ Cl H Cl CH₂C(═O)N(H)CH₂CH₂SMe Cl H ClCH₂C(═O)N(H)CH₂CH₂S(O)₂Me Br H Br CH₂CH₃ Br H Br CH₂—i-Pr Br H BrCH₂CH₂Cl Br H Br CH₂CH₂OH Br H Br CH(Me)CH₂OH Br H Br CH₂CH(Me)OH Br HBr CH₂C(Me)₂OH Br H Br CH₂CH₂CH₂OH Br H Br CH₂C(Me)₂CH₂OH Br H BrCH₂CH₂CH(Me)OH Br H Br CH₂C(═O)N(H)Et Br H Br CH₂C(═O)N(H)—i-Pr Br H BrCH₂C(═O)N(H)CH₂—i-Pr Br H Br CH(Me)C(═O)N(H)CH₂—i-Pr Br H BrCH₂C(═O)N(H)CH₂CH₂Cl Br H Br CH(Me)C(═O)N(H)CH₂CH₂Cl Br H BrCH₂C(═O)N(H)CH₂CH₂F Br H Br CH(Me)C(═O)N(H)CH₂CH₂F Br H Br CH₂CF₃ Br HBr CH₂—(2-Py) Br H Br CH₂—(4-Thz) Br H Br CH₂—c-Pr Br H Br CH₂CH₂SMe BrH Br CH(Me)CH₂SMe Br H Br CH₂CH₂CH₂SMe Br H Br CH₂CH₂S(═O)Me Br H BrCH(Me)CH₂S(═O)Me Br H Br CH₂CH₂CH₂S(═O)Me Br H Br CH₂CH₂S(O)₂Me Br H BrCH(Me)CH₂S(O)₂Me Br H Br CH₂CH₂CH₂S(O)₂Me Br H Br CH₂C(═O)N(H)CH₂CF₃ BrH Br CH(Me)C(═O)N(H)CH₂CF₃ Br H Br CH₂C(═O)N(H)CH₂CH₂SMe Br H BrCH₂C(═O)N(H)CH₂CH₂S(O)₂Me CF₃ H H CH₂CH₃ CF₃ H H CH₂—i-Pr CF₃ H HCH₂CH₂Cl CF₃ H H CH₂CH₂OH CF₃ H H CH(Me)CH₂OH CF₃ H H CH₂CH(Me)OH CF₃ HH CH₂C(Me)₂OH CF₃ H H CH₂CH₂CH₂OH CF₃ H H CH₂C(Me)₂CH₂OH CF₃ H HCH₂CH₂CH(Me)OH CF₃ H H CH₂C(═O)N(H)Et CF₃ H H CH₂C(═O)N(H)—i-Pr CF₃ H HCH₂C(═O)N(H)CH₂—i-Pr CF₃ H H CH(Me)C(═O)N(H)CH₂—i-Pr CF₃ H HCH₂C(═O)N(H)CH₂CH₂Cl CF₃ H H CH(Me)C(═O)N(H)CH₂CH₂Cl CF₃ H HCH₂C(═O)N(H)CH₂CH₂F CF₃ H H CH(Me)C(═O)N(H)CH₂CH₂F CF₃ H H CH₂CF₃ CF₃ HH CH₂—(2-Py) CF₃ H H CH₂—(4-Thz) CF₃ H H CH₂—c-Pr CF₃ H H CH₂CH₂SMe CF₃H H CH(Me)CH₂SMe CF₃ H H CH₂CH₂CH₂SMe CF₃ H H CH₂CH₂S(═O)Me CF₃ H HCH(Me)CH₂S(═O)Me CF₃ H H CH₂CH₂CH₂S(═O)Me CF₃ H H CH₂CH₂S(O)₂Me CF₃ H HCH(Me)CH₂S(O)₂Me CF₃ H H CH₂CH₂CH₂S(O)₂Me CF₃ H H CH₂C(═O)N(H)CH₂CF₃ CF₃H H CH(Me)C(═O)N(H)CH₂CF₃ CF₃ H H CH₂C(═O)N(H)CH₂CH₂SMe CF₃ H HCH₂C(═O)N(H)CH₂CH₂S(O)₂Me CF₃ H F CH₂CH₃ CF₃ H F CH₂—i-Pr CF₃ H FCH₂CH₂Cl CF₃ H F CH₂CH₂OH CF₃ H F CH(Me)CH₂OH CF₃ H F CH₂CH(Me)OH CF₃ HF CH₂C(Me)₂OH CF₃ H F CH₂CH₂CH₂OH CF₃ H F CH₂C(Me)₂CH₂OH CF₃ H FCH₂CH₂CH(Me)OH CF₃ H F CH₂C(═O)N(H)Et CF₃ H F CH₂C(═O)N(H)—i-Pr CF₃ H FCH₂C(═O)N(H)CH₂—i-Pr CF₃ H F CH(Me)C(═O)N(H)CH₂—i-Pr CF₃ H FCH₂C(═O)N(H)CH₂CH₂Cl CF₃ H F CH(Me)C(═O)N(H)CH₂CH₂Cl CF₃ H FCH₂C(═O)N(H)CH₂CH₂F CF₃ H F CH(Me)C(═O)N(H)CH₂CH₂F CF₃ H F CH₂CF₃ CF₃ HF CH₂—(2-Py) CF₃ H F CH₂—(4-Thz) CF₃ H F CH₂—c-Pr CF₃ H F CH₂CH₂SMe CF₃H F CH(Me)CH₂SMe CF₃ H F CH₂CH₂CH₂SMe CF₃ H F CH₂CH₂S(═O)Me CF₃ H FCH(Me)CH₂S(═O)Me CF₃ H F CH₂CH₂CH₂S(═O)Me CF₃ H F CH₂CH₂S(O)₂Me CF₃ H FCH(Me)CH₂S(O)₂Me CF₃ H F CH₂CH₂CH₂S(O)₂Me CF₃ H F CH₂C(═O)N(H)CH₂CF₃ CF₃H F CH(Me)C(═O)N(H)CH₂CF₃ CF₃ H F CH₂C(═O)N(H)CH₂CH₂SMe CF₃ H FCH₂C(═O)N(H)CH₂CH₂S(O)₂Me CF₃ H Br CH₂CH₃ CF₃ H Br CH₂—i-Pr CF₃ H BrCH₂CH₂Cl CF₃ H Br CH₂CH₂OH CF₃ H Br CH(Me)CH₂OH CF₃ H Br CH₂CH(Me)OH CF₃H Br CH₂C(Me)₂OH CF₃ H Br CH₂CH₂CH₂OH CF₃ H Br CH₂C(Me)₂CH₂OH CF₃ H BrCH₂CH₂CH(Me)OH CF₃ H Br CH₂C(═O)N(H)Et CF₃ H Br CH₂C(═O)N(H)—i-Pr CF₃ HBr CH₂C(═O)N(H)CH₂—i-Pr CF₃ H Br CH(Me)C(═O)N(H)CH₂—i-Pr CF₃ H BrCH₂C(═O)N(H)CH₂CH₂Cl CF₃ H Br CH(Me)C(═O)N(H)CH₂CH₂Cl CF₃ H BrCH₂C(═O)N(H)CH₂CH₂F CF₃ H Br CH(Me)C(═O)N(H)CH₂CH₂F CF₃ H Br CH₂CF₃ CF₃H Br CH₂—(2-Py) CF₃ H Br CH₂—(4-Thz) CF₃ H Br CH₂—c-Pr CF₃ H BrCH₂CH₂SMe CF₃ H Br CH(Me)CH₂SMe CF₃ H Br CH₂CH₂CH₂SMe CF₃ H BrCH₂CH₂S(═O)Me CF₃ H Br CH(Me)CH₂S(═O)Me CF₃ H Br CH₂CH₂CH₂S(═O)Me CF₃ HBr CH₂CH₂S(O)₂Me CF₃ H Br CH(Me)CH₂S(O)₂Me CF₃ H Br CH₂CH₂CH₂S(O)₂Me CF₃H Br CH₂C(═O)N(H)CH₂CF₃ CF₃ H Br CH(Me)C(═O)N(H)CH₂CF₃ CF₃ H BrCH₂C(═O)N(H)CH₂CH₂SMe CF₃ H Br CH₂C(═O)N(H)CH₂CH₂S(O)₂Me CF₃ H Cl CH₂CH₃CF₃ H Cl CH₂—i-Pr CF₃ H Cl CH₂CH₂Cl CF₃ H Cl CH₂CH₂OH CF₃ H ClCH(Me)CH₂OH CF₃ H Cl CH₂CH(Me)OH CF₃ H Cl CH₂C(Me)₂OH CF₃ H ClCH₂CH₂CH₂OH CF₃ H Cl CH₂C(Me)₂CH₂OH CF₃ H Cl CH₂CH₂CH(Me)OH CF₃ H ClCH₂C(═O)N(H)Et CF₃ H Cl CH₂C(═O)N(H)—i-Pr CF₃ H Cl CH₂C(═O)N(H)CH₂—i-PrCF₃ H Cl CH(Me)C(43)N(H)CH₂—i-Pr CF₃ H Cl CH₂C(═O)N(H)CH₂CH₂Cl CF₃ H ClCH(Me)C(═O)N(H)CH₂CH₂Cl CF₃ H Cl CH₂C(═O)N(H)CH₂CH₂F CF₃ H ClCH(Me)C(═O)N(H)CH₂CH₂F CF₃ H Cl CH₂CF₃ CF₃ H Cl CH₂—(2-Py) CF₃ H ClCH₂—(4-Thz) CF₃ H Cl CH₂—c-Pr CF₃ H Cl CH₂CH₂SMe CF₃ H Cl CH(Me)CH₂SMeCF₃ H Cl CH₂CH₂CH₂SMe CF₃ H Cl CH₂CH₂S(═O)Me CF₃ H Cl CH(Me)CH₂S(═O)MeCF₃ H Cl CH₂CH₂CH₂S(═O)Me CF₃ H Cl CH₂CH₂S(O)₂Me CF₃ H ClCH(Me)CH₂S(O)₂Me CF₃ H Cl CH₂CH₂CH₂S(O)₂Me CF₃ H Cl CH₂C(═O)N(H)CH₂CF₃CF₃ H Cl CH(Me)C(═O)N(H)CH₂CF₃ CF₃ H Cl CH₂C(═O)N(H)CH₂CH₂SMe CF₃ H ClCH₂C(═O)N(H)CH₂CH₂S(O)₂Me CF₃ H CF₃ CH₂CH₃ CF₃ H CF₃ CH₂—i-Pr CF₃ H CF₃CH₂CH₂Cl CF₃ H CF₃ CH₂CH₂OH CF₃ H CF₃ CH(Me)CH₂OH CF₃ H CF₃ CH₂CH(Me)OHCF₃ H CF₃ CH₂C(Me)₂OH CF₃ H CF₃ CH₂CH₂CH₂OH CF₃ H CF₃ CH₂C(Me)₂CH₂OH CF₃H CF₃ CH₂CH₂CH(Me)OH CF₃ H CF₃ CH₂C(═O)N(H)Et CF₃ H CF₃CH₂C(═O)N(H)—i-Pr CF₃ H CF₃ CH₂C(═O)N(H)CH₂—i-Pr CF₃ H CF₃CH(Me)C(═O)N(H)CH₂—i-Pr CF₃ H CF₃ CH₂C(═O)N(H)CH₂CH₂Cl CF₃ H CF₃CH(Me)C(═O)N(H)CH₂CH₂Cl CF₃ H CF₃ CH₂C(═O)N(H)CH₂CH₂F CF₃ H CF₃CH(Me)C(═O)N(H)CH₂CH₂F CF₃ H CF₃ CH₂CF₃ CF₃ H CF₃ CH₂—(2-Py) CF₃ H CF₃CH₂—(4-Thz) CF₃ H CF₃ CH₂—c-Pr CF₃ H CF₃ CH₂CH₂SMe CF₃ H CF₃CH(Me)CH₂SMe CF₃ H CF₃ CH₂CH₂CH₂SMe CF₃ H CF₃ CH₂CH₂S(═O)Me CF₃ H CF₃CH(Me)CH₂S(═O)Me CF₃ H CF₃ CH₂CH₂CH₂S(═O)Me CF₃ H CF₃ CH₂CH₂S(O)₂Me CF₃H CF₃ CH(Me)CH₂S(O)₂Me CF₃ H CF₃ CH₂CH₂CH₂S(O)₂Me CF₃ H CF₃CH₂C(═O)N(H)CH₂CF₃ CF₃ H CF₃ CH(Me)C(═O)N(H)CH₂CF₃ CF₃ H CF₃CH₂C(O)N(H)CH₂CH₂SMe CF₃ H CF₃ CH₂C(═O)N(H)CH₂CH₂S(O)₂Me Cl Cl Cl CH₂CH₃Cl Cl Cl CH₂—i-Pr Cl Cl Cl CH₂CH₂Cl Cl Cl Cl CH₂CH₂OH Cl Cl ClCH(Me)CH₂OH Cl Cl Cl CH₂CH(Me)OH Cl Cl Cl CH₂C(Me)₂OH Cl Cl ClCH₂CH₂CH₂OH Cl Cl Cl CH₂C(Me)₂CH₂OH Cl Cl Cl CH₂CH₂CH(Me)OH Cl Cl ClCH₂C(═O)N(H)Et Cl Cl Cl CH₂C(═O)N(H)—i-Pr Cl Cl Cl CH₂C(═O)N(H)CH₂—i-PrCl Cl Cl CH(Me)C(═O)N(H)CH₂—i-Pr Cl Cl Cl CH₂C(═O)N(H)CH₂CH₂Cl Cl Cl ClCH(Me)C(═O)N(H)CH₂CH₂Cl Cl Cl Cl CH₂C(═O)N(H)CH₂CH₂F Cl Cl ClCH(Me)C(═O)N(H)CH₂CH₂F Cl Cl Cl CH₂CF₃ Cl Cl Cl CH₂—(2-Py) Cl Cl ClCH₂—(4-Thz) Cl Cl Cl CH₂—c-Pr Cl Cl Cl CH₂CH₂SMe Cl Cl Cl CH(Me)CH₂SMeCl Cl Cl CH₂CH₂CH₂SMe Cl Cl Cl CH₂CH₂S(═O)Me Cl Cl Cl CH(Me)CH₂S(═O)MeCl Cl Cl CH₂CH₂CH₂S(═O)Me Cl Cl Cl CH₂CH₂S(O)₂Me Cl Cl ClCH(Me)CH₂S(O)₂Me Cl Cl Cl CH₂CH₂CH₂S(O)₂Me Cl Cl Cl CH₂C(═O)N(H)CH₂CF₃Cl Cl Cl CH(Me)C(═O)N(H)CH₂CF₃ Cl Cl Cl CH₂C(═O)N(H)CH₂CH₂SMe Cl Cl ClCH₂C(═O)N(H)CH₂CH₂S(O)₂Me Cl F Cl CH₂CH₃ Cl F Cl CH₂—i-Pr Cl F ClCH₂CH₂Cl Cl F Cl CH₂CH₂OH Cl F Cl CH(Me)CH₂OH Cl F Cl CH₂CH(Me)OH Cl FCl CH₂C(Me)₂OH Cl F Cl CH₂CH₂CH₂OH Cl F Cl CH₂C(Me)₂CH₂OH Cl F ClCH₂CH₂CH(Me)OH Cl F Cl CH₂C(═O)N(H)Et Cl F Cl CH₂C(═O)N(H)—i-Pr Cl F ClCH₂C(═O)N(H)CH₂—i-Pr Cl F Cl CH(Me)C(═O)N(H)CH₂—i-Pr Cl F ClCH₂C(═O)N(H)CH₂CH₂Cl Cl F Cl CH(Me)C(═O)N(H)CH₂CH₂Cl Cl F ClCH₂C(═O)N(H)CH₂CH₂F Cl F Cl CH(Me)C(═O)N(H)CH₂CH₂F Cl F Cl CH₂CF₃ Cl FCl CH₂—(2-Py) Cl F Cl CH₂—(4-Thz) Cl F Cl CH₂—c-Pr Cl F Cl CH₂CH₂SMe ClF Cl CH(Me)CH₂SMe Cl F Cl CH₂CH₂CH₂SMe Cl F Cl CH₂CH₂S(═O)Me Cl F ClCH(Me)CH₂S(═O)Me Cl F Cl CH₂CH₂CH₂S(═O)Me Cl F Cl CH₂CH₂S(O)₂Me Cl F ClCH(Me)CH₂S(O)₂Me Cl F Cl CH₂CH₂CH₂S(O)₂Me Cl F Cl CH₂C(═O)N(H)CH₂CF₃ ClF Cl CH(Me)C(═O)N(H)CH₂CF₃ Cl F Cl CH₂C(═O)N(H)CH₂CH₂SMe Cl F ClCH₂C(═O)N(H)CH₂CH₂S(O)₂Me OCF₃ H Cl CH₂CH₃ OCF₃ H Cl CH₂—i-Pr OCF₃ H ClCH₂CH₂Cl OCF₃ H Cl CH₂CH₂OH OCF₃ H Cl CH(Me)CH₂OH OCF₃ H Cl CH₂CH(Me)OHOCF₃ H Cl CH₂C(Me)₂OH OCF₃ H Cl CH₂CH₂CH₂OH OCF₃ H Cl CH₂C(Me)₂CH₂OHOCF₃ H Cl CH₂CH₂CH(Me)OH OCF₃ H Cl CH₂C(═O)N(H)Et OCF₃ H ClCH₂C(═O)N(H)—i-Pr OCF₃ H Cl CH₂C(═O)N(H)CH₂—i-Pr OCF₃ H ClCH(Me)C(═O)N(H)CH₂—i-Pr OCF₃ H Cl CH₂C(═O)N(H)CH₂CH₂Cl OCF₃ H ClCH(Me)C(═O)N(H)CH₂CH₂Cl OCF₃ H Cl CH₂C(═O)N(H)CH₂CH₂F OCF₃ H ClCH(Me)C(═O)N(H)CH₂CH₂F OCF₃ H Cl CH₂CF₃ OCF₃ H Cl CH₂—(2-Py) OCF₃ H ClCH₂—(4-Thz) OCF₃ H Cl CH₂—c-Pr OCF₃ H Cl CH₂CH₂SMe OCF₃ H ClCH(Me)CH₂SMe OCF₃ H Cl CH₂CH₂CH₂SMe OCF₃ H Cl CH₂CH₂S(═O)Me OCF₃ H ClCH(Me)CH₂S(═O)Me OCF₃ H Cl CH₂CH₂CH₂S(═O)Me OCF₃ H Cl CH₂CH₂S(O)₂Me OCF₃H Cl CH(Me)CH₂S(O)₂Me OCF₃ H Cl CH₂CH₂CH₂S(O)₂Me OCF₃ H ClCH₂C(═O)N(H)CH₂CF₃ OCF₃ H Cl CH(Me)C(═O)N(H)CH₂CF₃ OCF₃ H ClCH₂C(═O)N(H)CH₂CH₂SMe OCF₃ H Cl CH₂C(═O)N(H)CH₂CH₂S(O)₂Me

TABLE 2

R^(2a) R^(2b) R^(2c) R⁵ Cl H Cl CH₃ Cl H Cl CH₂CH₃ Cl H Cl CH₂—i-Pr Cl HCl n-Pr Cl H Cl i-Pr Cl H Cl s-Bu Cl H Cl t-Bu Cl H Cl (CH₂)₅CH₃ Cl H ClCH₂Ph Br H Br CH₃ Br H Br CH₂CH₃ Br H Br CH₂—i-Pr Br H Br n-Pr Br H Bri-Pr Br H Br s-Bu Br H Br t-Bu Br H Br (CH₂)₅CH₃ Br H Br CH₂Ph CF₃ H HCH₃ CF₃ H H CH₂CH₃ CF₃ H H CH₂—i-Pr CF₃ H H n-Pr CF₃ H H i-Pr CF₃ H Hs-Bu CF₃ H H t-Bu CF₃ H H (CH₂)₅CH₃ CF₃ H H CH₂Ph CF₃ H F CH₃ CF₃ H FCH₂CH₃ CF₃ H F CH₂—i-Pr CF₃ H F n-Pr CF₃ H F i-Pr CF₃ H F s-Bu CF₃ H Ft-Bu CF₃ H F (CH₂)₅CH₃ CF₃ H F CH₂Ph CF₃ H Br CH₃ CF₃ H Br CH₂CH₃ CF₃ HBr CH₂—i-Pr CF₃ H Br n-Pr CF₃ H Br i-Pr CF₃ H Br s-Bu CF₃ H Br t-Bu CF₃H Br (CH₂)₅CH₃ CF₃ H Br CH₂Ph CF₃ H Cl CH₃ CF₃ H Cl CH₂CH₃ CF₃ H ClCH₂—i-Pr CF₃ H Cl n-Pr CF₃ H Cl i-Pr CF₃ H Cl s-Bu CF₃ H Cl t-Bu CF₃ HCl (CH₂)₅CH₃ CF₃ H Cl CH₂Ph CF₃ H CF₃ CH₃ CF₃ H CF₃ CH₂CH₃ CF₃ H CF₃CH₂—i-Pr CF₃ H CF₃ n-Pr CF₃ H CF₃ i-Pr CF₃ H CF₃ s-Bu CF₃ H CF₃ t-Bu CF₃H CF₃ (CH₂)₅CH₃ CF₃ H CF₃ CH₂Ph Cl Cl Cl CH₃ Cl Cl Cl CH₂CH₃ Cl Cl ClCH₂—i-Pr Cl Cl Cl n-Pr Cl Cl Cl i-Pr Cl Cl Cl s-Bu Cl Cl Cl t-Bu Cl ClCl (CH₂)₅CH₃ Cl Cl Cl CH₂Ph Cl F Cl CH₃ Cl F Cl CH₂CH₃ Cl F Cl CH₂—i-PrCl F Cl n-Pr Cl F Cl i-Pr Cl F Cl s-Bu Cl F Cl t-Bu Cl F Cl (CH₂)₅CH₃ ClF Cl CH₂Ph OCF₃ H Cl CH₃ OCF₃ H Cl CH₂CH₃ OCF₃ H Cl CH₂—i-Pr OCF₃ H Cln-Pr OCF₃ H Cl i-Pr OCF₃ H Cl s-Bu OCF₃ H Cl t-Bu OCF₃ H Cl (CH₂)₅CH₃OCF₃ H Cl CH₂Ph

TABLE 3

R^(2a) R^(2b) R^(2c) R³ Cl H Cl Cl Cl H Cl Br Cl H Cl I Cl H Cl OH Cl HCl OMe Cl H Cl OS(O)₂CF₃ Cl H Cl nitro Cl H Cl NH₂ Cl H Cl cyano Cl H ClMe Cl H Cl CH₂Cl Cl H Cl CH₂Br Cl H Cl CH₂OH Cl H Cl CH₂OC(O)Me Cl H ClCO₂H Cl H Cl n-Pr Br H Br Cl Br H Br Br Br H Br I Br H Br OH Br H Br OMeBr H Br OS(O)₂CF₃ Br H Br nitro Br H Br NH₂ Br H Br cyano Br H Br Me BrH Br CH₂Cl Br H Br CH₂Br Br H Br CH₂OH Br H Br CH₂OC(O)Me Br H Br CO₂HBr H Br n-Pr CF₃ H H Cl CF₃ H H Br CF₃ H H I CF₃ H H OH CF₃ H H OMe CF₃H H OS(O)₂CF₃ CF₃ H H nitro CF₃ H H NH₂ CF₃ H H cyano CF₃ H H Me CF₃ H HCH₂Cl CF₃ H H CH₂Br CF₃ H H CH₂OH CF₃ H H CH₂OC(O)Me CF₃ H H CO₂H CF₃ HH n-Pr CF₃ H F Cl CF₃ H F Br CF₃ H F I CF₃ H F OH CF₃ H F OMe CF₃ H FOS(O)₂CF₃ CF₃ H F nitro CF₃ H F NH₂ CF₃ H F cyano CF₃ H F Me CF₃ H FCH₂Cl CF₃ H F CH₂Br CF₃ H F CH₂OH CF₃ H F CH₂OC(O)Me CF₃ H F CO₂H CF₃ HF n-Pr CF₃ H Br Cl CF₃ H Br Br CF₃ H Br I CF₃ H Br OH CF₃ H Br OMe CF₃ HBr OS(O)₂CF₃ CF₃ H Br nitro CF₃ H Br NH₂ CF₃ H Br cyano CF₃ H Br Me CF₃H Br CH₂Cl CF₃ H Br CH₂Br CF₃ H Br CH₂OH CF₃ H Br CH₂OC(O)Me CF₃ H BrCO₂H CF₃ H Br n-Pr CF₃ H Cl Cl CF₃ H Cl Br CF₃ H Cl I CF₃ H Cl OH CF₃ HCl OMe CF₃ H Cl OS(O)₂CF₃ CF₃ H Cl nitro CF₃ H Cl NH₂ CF₃ H Cl cyano CF₃H Cl Me CF₃ H Cl CH₂Cl CF₃ H Cl CH₂Br CF₃ H Cl CH₂OH CF₃ H Cl CH₂OC(O)MeCF₃ H Cl CO₂H CF₃ H Cl n-Pr CF₃ H CF₃ Cl CF₃ H CF₃ Br CF₃ H CF₃ I CF₃ HCF₃ OH CF₃ H CF₃ OMe CF₃ H CF₃ OS(O)₂CF₃ CF₃ H CF₃ nitro CF₃ H CF₃ NH₂CF₃ H CF₃ cyano CF₃ H CF₃ Me CF₃ H CF₃ CH₂Cl CF₃ H CF₃ CH₂Br CF₃ H CF₃CH₂OH CF₃ H CF₃ CH₂OC(O)Me CF₃ H CF₃ CO₂H CF₃ H CF₃ n-Pr Cl Cl Cl Cl ClCl Cl Br Cl Cl Cl I Cl Cl Cl OH Cl Cl Cl OMe Cl Cl Cl OS(O)₂CF₃ Cl Cl Clnitro Cl Cl Cl NH₂ Cl Cl Cl cyano Cl Cl Cl Me Cl Cl Cl CH₂Cl Cl Cl ClCH₂Br Cl Cl Cl CH₂OH Cl Cl Cl CH₂OC(O)Me Cl Cl Cl CO₂H Cl Cl Cl n-Pr ClF Cl Cl Cl F Cl Br Cl F Cl I Cl F Cl OH Cl F Cl OMe Cl F Cl OS(O)₂CF₃ ClF Cl nitro Cl F Cl NH₂ Cl F Cl cyano Cl F Cl Me Cl F Cl CH₂Cl Cl F ClCH₂Br Cl F Cl CH₂OH Cl F Cl CH₂OC(O)Me Cl F Cl CO₂H Cl F Cl n-Pr OCF₃ HCl Cl OCF₃ H Cl Br OCF₃ H Cl I OCF₃ H Cl OH OCF₃ H Cl OMe OCF₃ H ClOS(O)₂CF₃ OCF₃ H Cl nitro OCF₃ H Cl NH₂ OCF₃ H Cl cyano OCF₃ H Cl MeOCF₃ H Cl CH₂Cl OCF₃ H Cl CH₂Br OCF₃ H Cl CH₂OH OCF₃ H Cl CH₂OC(O)MeOCF₃ H Cl CO₂H OCF₃ H Cl n-Pr

TABLE 4

R^(2a) R^(2b) R^(2c) R¹ R³ Cl H Cl CF₃ H Cl H Cl CF₃ Me Cl Cl CN CF₃ CNCF₃ H H CF₃ H CF₃ H Me CF₃ Me CF₃ H H CF₃ CN CF₃ H Cl CF₃ H CF₃ H Cl CF₃Me CF₃ H Cl CF₃ CN Cl Cl Cl CF₃ H Cl Cl Cl CF₃ CN Cl Cl Cl CF₃ Me Cl HCl CF₂Cl H Cl H Cl CF₂Cl CN Cl H Cl CCl₂F H Cl H Cl CCl₂F CN Br H Br CF₃H Br H Br CF₃ Me Br H Br CF₃ CN CF₃ H F CF₃ H CF₃ H F CF₃ Me CF₃ H F CF₃CN CF₃ H CF₃ CF₃ H CF₃ H CF₃ CF₃ Me CF₃ H CF₃ CF₃ CN Cl F Cl CF₃ H Cl FCl CF₃ CN Cl F Cl CF₃ Me Cl H Cl CF₂CF₂H H Cl H Cl CF₂CF₂H CN Cl H ClCF₂CF₃ H Cl H Cl CF₂CF₃ CN

TABLE 5

R^(2a) R^(2b) R^(2c) R¹ R³ Cl H Cl CF₃ H Cl H Cl CF₃ Me Cl Cl CN CF₃ CNCF₃ H H CF₃ H CF₃ H Me CF₃ Me CF₃ H H CF₃ CN CF₃ H Cl CF₃ H CF₃ H Cl CF₃Me CF₃ H Cl CF₃ CN Cl Cl Cl CF₃ H Cl Cl Cl CF₃ CN Cl Cl Cl CF₃ Me Cl HCl CF₂Cl H Cl H Cl CF₂Cl CN Cl H Cl CCl₂F H Cl H Cl CCl₂F CN Br H Br CF₃H Br H Br CF₃ Me Br H Br CF₃ CN CF₃ H F CF₃ H CF₃ H F CF₃ Me CF₃ H F CF₃CN CF₃ H CF₃ CF₃ H CF₃ H CF₃ CF₃ Me CF₃ H CF₃ CF₃ CN Cl F Cl CF₃ H Cl FCl CF₃ CN Cl F Cl CF₃ Me Cl H Cl CF₂CF₂H H Cl H Cl CF₂CF₂H CN Cl H ClCF₂CF₃ H Cl H Cl CF₂CF₃ CN

TABLE 6

R^(2a) R^(2b) R^(2c) R^(v) R³ Cl H Cl Br H Cl H Cl Br Me Cl Cl Cl Br CNCF₃ H H Br H CF₃ H H Br Me CF₃ H H Br CN CF₃ H Cl Br H CF₃ H Cl Br MeCF₃ H Cl Br CN Cl Cl Cl Br H Cl Cl Cl Br CN Cl Cl Cl Br Me Br H Br Br HBr H Br Br Me Br H Br Br CN CF₃ H F Br H CF₃ H F Br Me CF₃ H F Br CN CF₃H CF₃ Br H CF₃ H CF₃ Br Me CF₃ H CF₃ Br CN Cl F Cl Br H Cl F Cl Br CN ClF Cl Br Me

Tables 7-9 relate to the method of Scheme 1a converting compounds ofFormulae 2 and 3 to corresponding compounds of Formula 1. Thistransformation is believed to occur through the intermediacy ofcompounds of Formula 11.

In the example transformations embodied in Tables 7-9, M¹ is K (i.e. thebase is potassium carbonate), and water is distilled as an azeotropefrom a reaction mixture comprising acetonitrile as the aprotic solventcapable of forming a low-boiling azeotrope with water.

TABLE 7

R^(2a) R^(2b) R^(2c) R⁵ Cl H Cl CH₂CH₃ Cl H Cl CH₂—i-Pr Cl H Cl CH₂CH₂ClCl H Cl CH₂CH₂OH Cl H Cl CH(Me)CH₂OH Cl H Cl CH₂CH(Me)OH Cl H ClCH₂C(Me)₂OH Cl H Cl CH₂CH₂CH₂OH Cl H Cl CH₂C(Me)₂CH₂OH Cl H ClCH₂CH₂CH(Me)OH Cl H Cl CH₂C(═O)N(H)Et Cl H Cl CH₂C(═O)N(H)—i-Pr Cl H ClCH₂C(═O)N(H)CH₂—i-Pr Cl H Cl CH(Me)C(═O)N(H)CH₂—i-Pr Cl H ClCH₂C(═O)N(H)CH₂CH₂Cl Cl H Cl CH(Me)C(═O)N(H)CH₂CH₂Cl Cl H ClCH₂C(═O)N(H)CH₂CH₂F Cl H Cl CH(Me)C(═O)N(H)CH₂CH₂F Cl H Cl CH₂CF₃ Cl HCl CH₂—(2-Py) Cl H Cl CH₂—(4-Thz) Cl H Cl CH₂—c-Pr Cl H Cl CH₂CH₂SMe ClH Cl CH(Me)CH₂SMe Cl H Cl CH₂CH₂CH₂SMe Cl H Cl CH₂CH₂S(═O)Me Cl H ClCH(Me)CH₂S(═O)Me Cl H Cl CH₂CH₂CH₂S(═O)Me Cl H Cl CH₂CH₂S(O)₂Me Cl H ClCH(Me)CH₂S(O)₂Me Cl H Cl CH₂CH₂CH₂S(O)₂Me Cl H Cl CH₂C(═O)N(H)CH₂CF₃ ClH Cl CH(Me)C(═O)N(H)CH₂CF₃ Cl H Cl CH₂C(═O)N(H)CH₂CH₂SMe Cl H ClCH₂C(═O)N(H)CH₂CH₂S(O)₂Me Br H Br CH₂CH₃ Br H Br CH₂—i-Pr Br H BrCH₂CH₂Cl Br H Br CH₂CH₂OH Br H Br CH(Me)CH₂OH Br H Br CH₂CH(Me)OH Br HBr CH₂C(Me)₂OH Br H Br CH₂CH₂CH₂OH Br H Br CH₂C(Me)₂CH₂OH Br H BrCH₂CH₂CH(Me)OH Br H Br CH₂C(═O)N(H)Et Br H Br CH₂C(═O)N(H)—i-Pr Br H BrCH₂C(═O)N(H)CH₂—i-Pr Br H Br CH(Me)C(═O)N(H)CH₂—i-Pr Br H BrCH₂C(═O)N(H)CH₂CH₂Cl Br H Br CH(Me)C(═O)N(H)CH₂CH₂Cl Br H BrCH₂C(═O)N(H)CH₂CH₂F Br H Br CH(Me)C(═O)N(H)CH₂CH₂F Br H Br CH₂CF₃ Br HBr CH₂—(2-Py) Br H Br CH₂—(4-Thz) Br H Br CH₂—c-Pr Br H Br CH₂CH₂SMe BrH Br CH(Me)CH₂SMe Br H Br CH₂CH₂CH₂SMe Br H Br CH₂CH₂S(═O)Me Br H BrCH(Me)CH₂S(═O)Me Br H Br CH₂CH₂CH₂S(═O)Me Br H Br CH₂CH₂S(O)₂Me Br H BrCH(Me)CH₂S(O)₂Me Br H Br CH₂CH₂CH₂S(O)₂Me Br H Br CH₂C(═O)N(H)CH₂CF₃ BrH Br CH(Me)C(═O)N(H)CH₂CF₃ Br H Br CH₂C(═O)N(H)CH₂CH₂SMe Br H BrCH₂C(═O)N(H)CH₂CH₂S(O)₂Me CF₃ H H CH₂CH₃ CF₃ H H CH₂—i-Pr CF₃ H HCH₂CH₂Cl CF₃ H H CH₂CH₂OH CF₃ H H CH(Me)CH₂OH CF₃ H H CH₂CH(Me)OH CF₃ HH CH₂C(Me)₂OH CF₃ H H CH₂CH₂CH₂OH CF₃ H H CH₂C(Me)₂CH₂OH CF₃ H HCH₂CH₂CH(Me)OH CF₃ H H CH₂C(═O)N(H)Et CF₃ H H CH₂C(═O)N(H)—i-Pr CF₃ H HCH₂C(═O)N(H)CH₂—i-Pr CF₃ H H CH(Me)C(═O)N(H)CH₂—i-Pr CF₃ H HCH₂C(═O)N(H)CH₂CH₂Cl CF₃ H H CH(Me)C(═O)N(H)CH₂CH₂Cl CF₃ H HCH₂C(═O)N(H)CH₂CH₂F CF₃ H H CH(Me)C(═O)N(H)CH₂CH₂F CF₃ H H CH₂CF₃ CF₃ HH CH₂—(2-Py) CF₃ H H CH₂—(4-Thz) CF₃ H H CH₂—c-Pr CF₃ H H CH₂CH₂SMe CF₃H H CH(Me)CH₂SMe CF₃ H H CH₂CH₂CH₂SMe CF₃ H H CH₂CH₂S(═O)Me CF₃ H HCH(Me)CH₂S(═O)Me CF₃ H H CH₂CH₂CH₂S(═O)Me CF₃ H H CH₂CH₂S(O)₂Me CF₃ H HCH(Me)CH₂S(O)₂Me CF₃ H H CH₂CH₂CH₂S(O)₂Me CF₃ H H CH₂C(═O)N(H)CH₂CF₃ CF₃H H CH(Me)C(═O)N(H)CH₂CF₃ CF₃ H H CH₂C(═O)N(H)CH₂CH₂SMe CF₃ H HCH₂C(═O)N(H)CH₂CH₂S(O)₂Me CF₃ H F CH₂CH₃ CF₃ H F CH₂—i-Pr CF₃ H FCH₂CH₂Cl CF₃ H F CH₂CH₂OH CF₃ H F CH(Me)CH₂OH CF₃ H F CH₂CH(Me)OH CF₃ HF CH₂C(Me)₂OH CF₃ H F CH₂CH₂CH₂OH CF₃ H F CH₂C(Me)₂CH₂OH CF₃ H FCH₂CH₂CH(Me)OH CF₃ H F CH₂C(═O)N(H)Et CF₃ H F CH₂C(═O)N(H)—i-Pr CF₃ H FCH₂C(═O)N(H)CH₂—i-Pr CF₃ H F CH(Me)C(═O)N(H)CH₂—i-Pr CF₃ H FCH₂C(═O)N(H)CH₂CH₂Cl CF₃ H F CH(Me)C(═O)N(H)CH₂CH₂Cl CF₃ H FCH₂C(═O)N(H)CH₂CH₂F CF₃ H F CH(Me)C(═O)N(H)CH₂CH₂F CF₃ H F CH₂CF₃ CF₃ HF CH₂—(2-Py) CF₃ H F CH₂—(4-Thz) CF₃ H F CH₂—c-Pr CF₃ H F CH₂CH₂SMe CF₃H F CH(Me)CH₂SMe CF₃ H F CH₂CH₂CH₂SMe CF₃ H F CH₂CH₂S(═O)Me CF₃ H FCH(Me)CH₂S(═O)Me CF₃ H F CH₂CH₂CH₂S(═O)Me CF₃ H F CH₂CH₂S(O)₂Me CF₃ H FCH(Me)CH₂S(O)₂Me CF₃ H F CH₂CH₂CH₂S(O)₂Me CF₃ H F CH₂C(═O)N(H)CH₂CF₃ CF₃H F CH(Me)C(═O)N(H)CH₂CF₃ CF₃ H F CH₂C(═O)N(H)CH₂CH₂SMe CF₃ H FCH₂C(═O)N(H)CH₂CH₂S(O)₂Me CF₃ H Br CH₂CH₃ CF₃ H Br CH₂—i-Pr CF₃ H BrCH₂CH₂Cl CF₃ H Br CH₂CH₂OH CF₃ H Br CH(Me)CH₂OH CF₃ H Br CH₂CH(Me)OH CF₃H Br CH₂C(Me)₂OH CF₃ H Br CH₂CH₂CH₂OH CF₃ H Br CH₂C(Me)₂CH₂OH CF₃ H BrCH₂CH₂CH(Me)OH CF₃ H Br CH₂C(═O)N(H)Et CF₃ H Br CH₂C(═O)N(H)—i-Pr CF₃ HBr CH₂C(═O)N(H)CH₂—i-Pr CF₃ H Br CH(Me)C(═O)N(H)CH₂—i-Pr CF₃ H BrCH₂C(═O)N(H)CH₂CH₂Cl CF₃ H Br CH(Me)C(═O)N(H)CH₂CH₂Cl CF₃ H BrCH₂C(═O)N(H)CH₂CH₂F CF₃ H Br CH(Me)C(═O)N(H)CH₂CH₂F CF₃ H Br CH₂CF₃ CF₃H Br CH₂—(2-Py) CF₃ H Br CH₂—(4-Thz) CF₃ H Br CH₂—c-Pr CF₃ H BrCH₂CH₂SMe CF₃ H Br CH(Me)CH₂SMe CF₃ H Br CH₂CH₂CH₂SMe CF₃ H BrCH₂CH₂S(═O)Me CF₃ H Br CH(Me)CH₂S(═O)Me CF₃ H Br CH₂CH₂CH₂S(═O)Me CF₃ HBr CH₂CH₂S(O)₂Me CF₃ H Br CH(Me)CH₂S(O)₂Me CF₃ H Br CH₂CH₂CH₂S(O)₂Me CF₃H Br CH₂C(═O)N(H)CH₂CF₃ CF₃ H Br CH(Me)C(═O)N(H)CH₂CF₃ CF₃ H BrCH₂C(═O)N(H)CH₂CH₂SMe CF₃ H Br CH₂C(═O)N(H)CH₂CH₂S(O)₂Me CF₃ H Cl CH₂CH₃CF₃ H Cl CH₂—i-Pr CF₃ H Cl CH₂CH₂Cl CF₃ H Cl CH₂CH₂OH CF₃ H ClCH(Me)CH₂OH CF₃ H Cl CH₂CH(Me)OH CF₃ H Cl CH₂C(Me)₂OH CF₃ H ClCH₂CH₂CH₂OH CF₃ H Cl CH₂C(Me)₂CH₂OH CF₃ H Cl CH₂CH₂CH(Me)OH CF₃ H ClCH₂C(═O)N(H)Et CF₃ H Cl CH₂C(═O)N(H)—i-Pr CF₃ H Cl CH₂C(═O)N(H)CH₂—i-PrCF₃ H Cl CH(Me)C(═O)N(H)CH₂—i-Pr CF₃ H Cl CH₂C(═O)N(H)CH₂CH₂Cl CF₃ H ClCH(Me)C(═O)N(H)CH₂CH₂Cl CF₃ H Cl CH₂C(═O)N(H)CH₂CH₂F CF₃ H ClCH(Me)C(═O)N(H)CH₂CH₂F CF₃ H Cl CH₂CF₃ CF₃ H Cl CH₂—(2-Py) CF₃ H ClCH₂—(4-Thz) CF₃ H Cl CH₂—c-Pr CF₃ H Cl CH₂CH₂SMe CF₃ H Cl CH(Me)CH₂SMeCF₃ H Cl CH₂CH₂CH₂SMe CF₃ H Cl CH₂CH₂S(═O)Me CF₃ H Cl CH(Me)CH₂S(═O)MeCF₃ H Cl CH₂CH₂CH₂S(═O)Me CF₃ H Cl CH₂CH₂S(O)₂Me CF₃ H ClCH(Me)CH₂S(O)₂Me CF₃ H Cl CH₂CH₂CH₂S(O)₂Me CF₃ H Cl CH₂C(═O)N(H)CH₂CF₃CF₃ H Cl CH(Me)C(═O)N(H)CH₂CF₃ CF₃ H Cl CH₂C(═O)N(H)CH₂CH₂SMe CF₃ H ClCH₂C(═O)N(H)CH₂CH₂S(O)₂Me CF₃ H CF₃ CH₂CH₃ CF₃ H CF₃ CH₂—i-Pr CF₃ H CF₃CH₂CH₂Cl CF₃ H CF₃ CH₂CH₂OH CF₃ H CF₃ CH(Me)CH₂OH CF₃ H CF₃ CH₂CH(Me)OHCF₃ H CF₃ CH₂C(Me)₂OH CF₃ H CF₃ CH₂CH₂CH₂OH CF₃ H CF₃ CH₂C(Me)₂CH₂OH CF₃H CF₃ CH₂CH₂CH(Me)OH CF₃ H CF₃ CH₂C(═O)N(H)Et CF₃ H CF₃CH₂C(═O)N(H)—i-Pr CF₃ H CF₃ CH₂C(═O)N(H)CH₂—i-Pr CF₃ H CF₃CH(Me)C(═O)N(H)CH₂—i-Pr CF₃ H CF₃ CH₂C(═O)N(H)CH₂CH₂Cl CF₃ H CF₃CH(Me)C(═O)N(H)CH₂CH₂Cl CF₃ H CF₃ CH₂C(═O)N(H)CH₂CH₂F CF₃ H CF₃CH(Me)C(═O)N(H)CH₂CH₂F CF₃ H CF₃ CH₂CF₃ CF₃ H CF₃ CH₂—(2-Py) CF₃ H CF₃CH₂—(4-Thz) CF₃ H CF₃ CH₂—c-Pr CF₃ H CF₃ CH₂CH₂SMe CF₃ H CF₃CH(Me)CH₂SMe CF₃ H CF₃ CH₂CH₂CH₂SMe CF₃ H CF₃ CH₂CH₂S(═O)Me CF₃ H CF₃CH(Me)CH₂S(═O)Me CF₃ H CF₃ CH₂CH₂CH₂S(═O)Me CF₃ H CF₃ CH₂CH₂S(O)₂Me CF₃H CF₃ CH(Me)CH₂S(O)₂Me CF₃ H CF₃ CH₂CH₂CH₂S(O)₂Me CF₃ H CF₃CH₂C(═O)N(H)CH₂CF₃ CF₃ H CF₃ CH(Me)C(═O)N(H)CH₂CF₃ CF₃ H CF₃CH₂C(═O)N(H)CH₂CH₂SMe CF₃ H CF₃ CH₂C(═O)N(H)CH₂CH₂S(O)₂Me Cl Cl ClCH₂CH₃ Cl Cl Cl CH₂—i-Pr Cl Cl Cl CH₂CH₂Cl Cl Cl Cl CH₂CH₂OH Cl Cl ClCH(Me)CH₂OH Cl Cl Cl CH₂CH(Me)OH Cl Cl Cl CH₂C(Me)₂OH Cl Cl ClCH₂CH₂CH₂OH Cl Cl Cl CH₂C(Me)₂CH₂OH Cl Cl Cl CH₂CH₂CH(Me)OH Cl Cl ClCH₂C(═O)N(H)Et Cl Cl Cl CH₂C(═O)N(H)—i-Pr Cl Cl Cl CH₂C(═O)N(H)CH₂—i-PrCl Cl Cl CH(Me)C()N(H)CH₂—i-Pr Cl Cl Cl CH₂C(═O)N(H)CH₂CH₂Cl Cl Cl ClCH(Me)C(═O)N(H)CH₂CH₂Cl Cl Cl Cl CH₂C(═O)N(H)CH₂CH₂F Cl Cl ClCH(Me)C(═O)N(H)CH₂CH₂F Cl Cl Cl CH₂CF₃ Cl Cl Cl CH₂—(2-Py) Cl Cl ClCH₂—(4-Thz) Cl Cl Cl CH₂—c-Pr Cl Cl Cl CH₂CH₂SMe Cl Cl Cl CH(Me)CH₂SMeCl Cl Cl CH₂CH₂CH₂SMe Cl Cl Cl CH₂CH₂S(═O)Me Cl Cl Cl CH(Me)CH₂S(═O)MeCl Cl Cl CH₂CH₂CH₂S(═O)Me Cl Cl Cl CH₂CH₂S(O)₂Me Cl Cl ClCH(Me)CH₂S(O)₂Me Cl Cl Cl CH₂CH₂CH₂S(O)₂Me Cl Cl Cl CH₂C(═O)N(H)CH₂CF₃Cl Cl Cl CH(Me)C(═O)N(H)CH₂CF₃ Cl Cl Cl CH₂C(═O)N(H)CH₂CH₂SMe Cl Cl ClCH₂C(═O)N(H)CH₂CH₂S(O)₂Me Cl F Cl CH₂CH₃ Cl F Cl CH₂—i-Pr Cl F ClCH₂CH₂Cl Cl F Cl CH₂CH₂OH Cl F Cl CH(Me)CH₂OH Cl F Cl CH₂CH(Me)OH Cl FCl CH₂C(Me)₂OH Cl F Cl CH₂CH₂CH₂OH Cl F Cl CH₂C(Me)₂CH₂OH Cl F ClCH₂CH₂CH(Me)OH Cl F Cl CH₂C(═O)N(H)Et Cl F Cl CH₂C(═O)N(H)—i-Pr Cl F ClCH₂C(═O)N(H)CH₂—i-Pr Cl F Cl CH(Me)C()N(H)CH₂—i-Pr Cl F ClCH₂C(═O)N(H)CH₂CH₂Cl Cl F Cl CH(Me)C(═O)N(H)CH₂CH₂Cl Cl F ClCH₂C(═O)N(H)CH₂CH₂F Cl F Cl CH(Me)C(═O)N(H)CH₂CH₂F Cl F Cl CH₂CF₃ Cl FCl CH₂—(2-Py) Cl F Cl CH₂—(4-Thz) Cl F Cl CH₂—c-Pr Cl F Cl CH₂CH₂SMe ClF Cl CH(Me)CH₂SMe Cl F Cl CH₂CH₂CH₂SMe Cl F Cl CH₂CH₂S(═O)Me Cl F ClCH(Me)CH₂S(═O)Me Cl F Cl CH₂CH₂CH₂S(═O)Me Cl F Cl CH₂CH₂S(O)₂Me Cl F ClCH(Me)CH₂S(O)₂Me Cl F Cl CH₂CH₂CH₂S(O)₂Me Cl F Cl CH₂C(═O)N(H)CH₂CF₃ ClF Cl CH(Me)C(═O)N(H)CH₂CF₃ Cl F Cl CH₂C(═O)N(H)CH₂CH₂SMe Cl F ClCH₂C(═O)N(H)CH₂CH₂S(O)₂Me OCF₃ H Cl CH₂CH₃ OCF₃ H Cl CH₂—i-Pr OCF₃ H ClCH₂CH₂Cl OCF₃ H Cl CH₂CH₂OH OCF₃ H Cl CH(Me)CH₂OH OCF₃ H Cl CH₂CH(Me)OHOCF₃ H Cl CH₂C(Me)₂OH OCF₃ H Cl CH₂CH₂CH₂OH OCF₃ H Cl CH₂C(Me)₂CH₂OHOCF₃ H Cl CH₂CH₂CH(Me)OH OCF₃ H Cl CH₂C(═O)N(H)Et OCF₃ H ClCH₂C(═O)N(H)—i-Pr OCF₃ H Cl CH₂C(═O)N(H)CH₂—i-Pr OCF₃ H ClCH(Me)C(═O)N(H)CH₂—i-Pr OCF₃ H Cl CH₂C(═O)N(H)CH₂CH₂Cl OCF₃ H ClCH(Me)C(═O)N(H)CH₂CH₂Cl OCF₃ H Cl CH₂C(═O)N(H)CH₂CH₂F OCF₃ H ClCH(Me)C(═O)N(H)CH₂CH₂F OCF₃ H Cl CH₂CF₃ OCF₃ H Cl CH₂—(2-Py) OCF₃ H ClCH₂—(4-Thz) OCF₃ H Cl CH₂—c-Pr OCF₃ H Cl CH₂CH₂SMe OCF₃ H ClCH(Me)CH₂SMe OCF₃ H Cl CH₂CH₂CH₂SMe OCF₃ H Cl CH₂CH₂S(═O)Me OCF₃ H ClCH(Me)CH₂S(═O)Me OCF₃ H Cl CH₂CH₂CH₂S(═O)Me OCF₃ H Cl CH₂CH₂S(O)₂Me OCF₃H Cl CH(Me)CH₂S(O)₂Me OCF₃ H Cl CH₂CH₂CH₂S(O)₂Me OCF₃ H ClCH₂C(═O)N(H)CH₂CF₃ OCF₃ H Cl CH(Me)C(═O)N(H)CH₂CF₃ OCF₃ H ClCH₂C(═O)N(H)CH₂CH₂SMe OCF₃ H Cl CH₂C(═O)N(H)CH₂CH₂S(O)₂Me

TABLE 8

R^(2a) R^(2b) R^(2c) R⁵ Cl H Cl CH₃ Cl H Cl CH₂CH₃ Cl H Cl CH₂—i-Pr Cl HCl n-Pr Cl H Cl i-Pr Cl H Cl s-Bu Cl H Cl t-Bu Cl H Cl (CH₂)₅CH₃ Cl H ClCH₂Ph Br H Br CH₃ Br H Br CH₂CH₃ Br H Br CH₂—i-Pr Br H Br n-Pr Br H Bri-Pr Br H Br s-Bu Br H Br t-Bu Br H Br (CH₂)₅CH₃ Br H Br CH₂Ph CF₃ H HCH₃ CF₃ H H CH₂CH₃ CF₃ H H CH₂—i-Pr CF₃ H H n-Pr CF₃ H H i-Pr CF₃ H Hs-Bu CF₃ H H t-Bu CF₃ H H (CH₂)₅CH₃ CF₃ H H CH₂Ph CF₃ H F CH₃ CF₃ H FCH₂CH₃ CF₃ H F CH₂—i-Pr CF₃ H F n-Pr CF₃ H F i-Pr CF₃ H F s-Bu CF₃ H Ft-Bu CF₃ H F (CH₂)₅CH₃ CF₃ H F CH₂Ph CF₃ H Br CH₃ CF₃ H Br CH₂CH₃ CF₃ HBr CH₂—i-Pr CF₃ H Br n-Pr CF₃ H Br i-Pr CF₃ H Br s-Bu CF₃ H Br t-Bu CF₃H Br (CH₂)₅CH₃ CF₃ H Br CH₂Ph CF₃ H Cl CH₃ CF₃ H Cl CH₂CH₃ CF₃ H ClCH₂—i-Pr CF₃ H Cl n-Pr CF₃ H Cl i-Pr CF₃ H Cl s-Bu CF₃ H Cl t-Bu CF₃ HCl (CH₂)₅CH₃ CF₃ H Cl CH₂Ph CF₃ H CF₃ CH₃ CF₃ H CF₃ CH₂CH₃ CF₃ H CF₃CH₂—i-Pr CF₃ H CF₃ n-Pr CF₃ H CF₃ i-Pr CF₃ H CF₃ s-Bu CF₃ H CF₃ t-Bu CF₃H CF₃ (CH₂)₅CH₃ CF₃ H CF₃ CH₂Ph Cl Cl Cl CH₃ Cl Cl Cl CH₂CH₃ Cl Cl ClCH₂—i-Pr Cl Cl Cl n-Pr Cl Cl Cl i-Pr Cl Cl Cl s-Bu Cl Cl Cl t-Bu Cl ClCl (CH₂)₅CH₃ Cl Cl Cl CH₂Ph Cl F Cl CH₃ Cl F Cl CH₂CH₃ Cl F Cl CH₂—i-PrCl F Cl n-Pr Cl F Cl i-Pr Cl F Cl s-Bu Cl F Cl t-Bu Cl F Cl (CH₂)₅CH₃ ClF Cl CH₂Ph OCF₃ H Cl CH₃ OCF₃ H Cl CH₂CH₃ OCF₃ H Cl CH₂—i-Pr OCF₃ H Cln-Pr OCF₃ H Cl i-Pr OCF₃ H Cl s-Bu OCF₃ H Cl t-Bu OCF₃ H Cl (CH₂)₅CH₃OCF₃ H Cl CH₂Ph

TABLE 9

R^(2a) R^(2b) R^(2c) R³ Cl H Cl Cl Cl H Cl Br Cl H Cl I Cl H Cl OH Cl HCl OMe Cl H Cl OS(O)₂CF₃ Cl H Cl nitro Cl H Cl NH₂ Cl H Cl cyano Cl H ClMe Cl H Cl CH₂Cl Cl H Cl CH₂Br Cl H Cl CH₂OH Cl H Cl CH₂OC(O)Me Cl H ClCO₂H Cl H Cl n-Pr Br H Br Cl Br H Br Br Br H Br I Br H Br OH Br H Br OMeBr H Br OS(O)₂CF₃ Br H Br nitro Br H Br NH₂ Br H Br cyano Br H Br Me BrH Br CH₂Cl Br H Br CH₂Br Br H Br CH₂OH Br H Br CH₂OC(O)Me Br H Br CO₂HBr H Br n-Pr CF₃ H H Cl CF₃ H H Br CF₃ H H I CF₃ H H OH CF₃ H H OMe CF₃H H OS(O)₂CF₃ CF₃ H H nitro CF₃ H H NH₂ CF₃ H H cyano CF₃ H H Me CF₃ H HCH₂Cl CF₃ H H CH₂Br CF₃ H H CH₂OH CF₃ H H CH₂OC(O)Me CF₃ H H CO₂H CF₃ HH n-Pr CF₃ H F Cl CF₃ H F Br CF₃ H F I CF₃ H F OH CF₃ H F OMe CF₃ H FOS(O)₂CF₃ CF₃ H F nitro CF₃ H F NH₂ CF₃ H F cyano CF₃ H F Me CF₃ H FCH₂Cl CF₃ H F CH₂Br CF₃ H F CH₂OH CF₃ H F CH₂OC(O)Me CF₃ H F CO₂H CF₃ HF n-Pr CF₃ H Br Cl CF₃ H Br Br CF₃ H Br I CF₃ H Br OH CF₃ H Br OMe CF₃ HBr OS(O)₂CF₃ CF₃ H Br nitro CF₃ H Br NH₂ CF₃ H Br cyano CF₃ H Br Me CF₃H Br CH₂Cl CF₃ H Br CH₂Br CF₃ H Br CH₂OH CF₃ H Br CH₂OC(O)Me CF₃ H BrCO₂H CF₃ H Br n-Pr CF₃ H Cl Cl CF₃ H Cl Br CF₃ H Cl I CF₃ H Cl OH CF₃ HCl OMe CF₃ H Cl OS(O)₂CF₃ CF₃ H Cl nitro CF₃ H Cl NH₂ CF₃ H Cl cyano CF₃H Cl Me CF₃ H Cl CH₂Cl CF₃ H Cl CH₂Br CF₃ H Cl CH₂OH CF₃ H Cl CH₂OC(O)MeCF₃ H Cl CO₂H CF₃ H Cl n-Pr CF₃ H CF₃ Cl CF₃ H CF₃ Br CF₃ H CF₃ I CF₃ HCF₃ OH CF₃ H CF₃ OMe CF₃ H CF₃ OS(O)₂CF₃ CF₃ H CF₃ nitro CF₃ H CF₃ NH₂CF₃ H CF₃ cyano CF₃ H CF₃ Me CF₃ H CF₃ CH₂Cl CF₃ H CF₃ CH₂Br CF₃ H CF₃CH₂OH CF₃ H CF₃ CH₂OC(O)Me CF₃ H CF₃ CO₂H CF₃ H CF₃ n-Pr Cl Cl Cl Cl ClCl Cl Br Cl Cl Cl I Cl Cl Cl OH Cl Cl Cl OMe Cl Cl Cl OS(O)₂CF₃ Cl Cl Clnitro Cl Cl Cl NH₂ Cl Cl Cl cyano Cl Cl Cl Me Cl Cl Cl CH₂Cl Cl Cl ClCH₂Br Cl Cl Cl CH₂OH Cl Cl Cl CH₂OC(O)Me Cl Cl Cl CO₂H Cl Cl Cl n-Pr ClF Cl Cl Cl F Cl Br Cl F Cl I Cl F Cl OH Cl F Cl OMe Cl F Cl OS(O)₂CF₃ ClF Cl nitro Cl F Cl NH₂ Cl F Cl cyano Cl F Cl Me Cl F Cl CH₂Cl Cl F ClCH₂Br Cl F Cl CH₂OH Cl F Cl CH₂OC(O)Me Cl F Cl CO₂H Cl F Cl n-Pr OCF₃ HCl Cl OCF₃ H Cl Br OCF₃ H Cl I OCF₃ H Cl OH OCF₃ H Cl OMe OCF₃ H ClOS(O)₂CF₃ OCF₃ H Cl nitro OCF₃ H Cl NH₂ OCF₃ H Cl cyano OCF₃ H Cl MeOCF₃ H Cl CH₂Cl OCF₃ H Cl CH₂Br OCF₃ H Cl CH₂OH OCF₃ H Cl CH₂OC(O)MeOCF₃ H Cl CO₂H OCF₃ H Cl n-Pr

Tables 10-12 relate to the method of Scheme 1b converting compounds ofFormulae 2 and 3 to corresponding compounds of Formula 1. Thistransformation is believed to occur through the intermediacy ofcompounds of Formula 11.

In the example transformations embodied in Tables 10-12, the base is1,8-diazabicyclo[5.4.0]undec-7-ene, and water is distilled as anazeotrope from a reaction mixture comprising acetonitrile as the aproticsolvent capable of forming a low-boiling azeotrope with water.

TABLE 10

R^(2a) R^(2b) R^(2c) R⁵ Cl H Cl CH₂CH₃ Cl H Cl CH₂—i-Pr Cl H Cl CH₂CH₂ClCl H Cl CH₂CH₂OH Cl H Cl CH(Me)CH₂OH Cl H Cl CH₂CH(Me)OH Cl H ClCH₂C(Me)₂OH Cl H Cl CH₂CH₂CH₂OH Cl H Cl CH₂C(Me)₂CH₂OH Cl H ClCH₂CH₂CH(Me)OH Cl H Cl CH₂C(═O)N(H)Et Cl H Cl CH₂C(═O)N(H)—i-Pr Cl H ClCH₂C(═O)N(H)CH₂—i-Pr Cl H Cl CH(Me)C(═O)N(H)CH₂—i-Pr Cl H ClCH₂C(═O)N(H)CH₂CH₂Cl Cl H Cl CH(Me)C(═O)N(H)CH₂CH₂Cl Cl H ClCH₂C(═O)N(H)CH₂CH₂F Cl H Cl CH(Me)C(═O)N(H)CH₂CH₂F Cl H Cl CH₂CF₃ Cl HCl CH₂—(2-Py) Cl H Cl CH₂—(4-Thz) Cl H Cl CH₂—c-Pr Cl H Cl CH₂CH₂SMe ClH Cl CH(Me)CH₂SMe Cl H Cl CH₂CH₂CH₂SMe Cl H Cl CH₂CH₂S(═O)Me Cl H ClCH(Me)CH₂S(═O)Me Cl H Cl CH₂CH₂CH₂S(═O)Me Cl H Cl CH₂CH₂S(O)₂Me Cl H ClCH(Me)CH₂S(O)₂Me Cl H Cl CH₂CH₂CH₂S(O)₂Me Cl H Cl CH₂C(═O)N(H)CH₂CF₃ ClH Cl CH(Me)C(═O)N(H)CH₂CF₃ Cl H Cl CH₂C(═O)N(H)CH₂CH₂SMe Cl H ClCH₂C(═O)N(H)CH₂CH₂S(O)₂Me Br H Br CH₂CH₃ Br H Br CH₂—i-Pr Br H BrCH₂CH₂Cl Br H Br CH₂CH₂OH Br H Br CH(Me)CH₂OH Br H Br CH₂CH(Me)OH Br HBr CH₂C(Me)₂OH Br H Br CH₂CH₂CH₂OH Br H Br CH₂C(Me)₂CH₂OH Br H BrCH₂CH₂CH(Me)OH Br H Br CH₂C(═O)N(H)Et Br H Br CH₂C(═O)N(H)—i-Pr Br H BrCH₂C(═O)N(H)CH₂—i-Pr Br H Br CH(Me)C(═O)N(H)CH₂—i-Pr Br H BrCH₂C(═O)N(H)CH₂CH₂Cl Br H Br CH(Me)C(═O)N(H)CH₂CH₂Cl Br H BrCH₂C(═O)N(H)CH₂CH₂F Br H Br CH(Me)C(═O)N(H)CH₂CH₂F Br H Br CH₂CF₃ Br HBr CH₂—(2-Py) Br H Br CH₂—(4-Thz) Br H Br CH₂—c-Pr Br H Br CH₂CH₂SMe BrH Br CH(Me)CH₂SMe Br H Br CH₂CH₂CH₂SMe Br H Br CH₂CH₂S(═O)Me Br H BrCH(Me)CH₂S(═O)Me Br H Br CH₂CH₂CH₂S(═O)Me Br H Br CH₂CH₂S(O)₂Me Br H BrCH(Me)CH₂S(O)₂Me Br H Br CH₂CH₂CH₂S(O)₂Me Br H Br CH₂C(═O)N(H)CH₂CF₃ BrH Br CH(Me)C(═O)N(H)CH₂CF₃ Br H Br CH₂C(═O)N(H)CH₂CH₂SMe Br H BrCH₂C(═O)N(H)CH₂CH₂S(O)₂Me CF₃ H H CH₂CH₃ CF₃ H H CH₂—i-Pr CF₃ H HCH₂CH₂Cl CF₃ H H CH₂CH₂OH CF₃ H H CH(Me)CH₂OH CF₃ H H CH₂CH(Me)OH CF₃ HH CH₂C(Me)₂OH CF₃ H H CH₂CH₂CH₂OH CF₃ H H CH₂C(Me)₂CH₂OH CF₃ H HCH₂CH₂CH(Me)OH CF₃ H H CH₂C(═O)N(H)Et CF₃ H H CH₂C(═O)N(H)—i-Pr CF₃ H HCH₂C(═O)N(H)CH₂—i-Pr CF₃ H H CH(Me)C(═O)N(H)CH₂—i-Pr CF₃ H HCH₂C(═O)N(H)CH₂CH₂Cl CF₃ H H CH(Me)C(═O)N(H)CH₂CH₂Cl CF₃ H HCH₂C(═O)N(H)CH₂CH₂F CF₃ H H CH(Me)C(═O)N(H)CH₂CH₂F CF₃ H H CH₂CF₃ CF₃ HH CH₂—(2-Py) CF₃ H H CH₂—(4-Thz) CF₃ H H CH₂—c-Pr CF₃ H H CH₂CH₂SMe CF₃H H CH(Me)CH₂SMe CF₃ H H CH₂CH₂CH₂SMe CF₃ H H CH₂CH₂S(═O)Me CF₃ H HCH(Me)CH₂S(═O)Me CF₃ H H CH₂CH₂CH₂S(═O)Me CF₃ H H CH₂CH₂S(O)₂Me CF₃ H HCH(Me)CH₂S(O)₂Me CF₃ H H CH₂CH₂CH₂S(O)₂Me CF₃ H H CH₂C(═O)N(H)CH₂CF₃ CF₃H H CH(Me)C(═O)N(H)CH₂CF₃ CF₃ H H CH₂C(═O)N(H)CH₂CH₂SMe CF₃ H HCH₂C(═O)N(H)CH₂CH₂S(O)₂Me CF₃ H F CH₂CH₃ CF₃ H F CH₂—i-Pr CF₃ H FCH₂CH₂Cl CF₃ H F CH₂CH₂OH CF₃ H F CH(Me)CH₂OH CF₃ H F CH₂CH(Me)OH CF₃ HF CH₂C(Me)₂OH CF₃ H F CH₂CH₂CH₂OH CF₃ H F CH₂C(Me)₂CH₂OH CF₃ H FCH₂CH₂CH(Me)OH CF₃ H F CH₂C(═O)N(H)Et CF₃ H F CH₂C(═O)N(H)—i-Pr CF₃ H FCH₂C(═O)N(H)CH₂—i-Pr CF₃ H F CH(Me)C(═O)N(H)CH₂—i-Pr CF₃ H FCH₂C(═O)N(H)CH₂CH₂Cl CF₃ H F CH(Me)C(═O)N(H)CH₂CH₂Cl CF₃ H FCH₂C(═O)N(H)CH₂CH₂F CF₃ H F CH(Me)C(═O)N(H)CH₂CH₂F CF₃ H F CH₂CF₃ CF₃ HF CH₂—(2-Py) CF₃ H F CH₂—(4-Thz) CF₃ H F CH₂—c-Pr CF₃ H F CH₂CH₂SMe CF₃H F CH(Me)CH₂SMe CF₃ H F CH₂CH₂CH₂SMe CF₃ H F CH₂CH₂S(═O)Me CF₃ H FCH(Me)CH₂S(═O)Me CF₃ H F CH₂CH₂CH₂S(═O)Me CF₃ H F CH₂CH₂S(O)₂Me CF₃ H FCH(Me)CH₂S(O)₂Me CF₃ H F CH₂CH₂CH₂S(O)₂Me CF₃ H F CH₂C(═O)N(H)CH₂CF₃ CF₃H F CH(Me)C(═O)N(H)CH₂CF₃ CF₃ H F CH₂C(═O)N(H)CH₂CH₂SMe CF₃ H FCH₂C(═O)N(H)CH₂CH₂S(O)₂Me CF₃ H Br CH₂CH₃ CF₃ H Br CH₂—i-Pr CF₃ H BrCH₂CH₂Cl CF₃ H Br CH₂CH₂OH CF₃ H Br CH(Me)CH₂OH CF₃ H Br CH₂CH(Me)OH CF₃H Br CH₂C(Me)₂OH CF₃ H Br CH₂CH₂CH₂OH CF₃ H Br CH₂C(Me)₂CH₂OH CF₃ H BrCH₂CH₂CH(Me)OH CF₃ H Br CH₂C(═O)N(H)Et CF₃ H Br CH₂C(═O)N(H)—i-Pr CF₃ HBr CH₂C(═O)N(H)CH₂—i-Pr CF₃ H Br CH(Me)C(═O)N(H)CH₂—i-Pr CF₃ H BrCH₂C(═O)N(H)CH₂CH₂Cl CF₃ H Br CH(Me)C(═O)N(H)CH₂CH₂Cl CF₃ H BrCH₂C(═O)N(H)CH₂CH₂F CF₃ H Br CH(Me)C(═O)N(H)CH₂CH₂F CF₃ H Br CH₂CF₃ CF₃H Br CH₂—(2-Py) CF₃ H Br CH₂—(4-Thz) CF₃ H Br CH₂—c-Pr CF₃ H BrCH₂CH₂SMe CF₃ H Br CH(Me)CH₂SMe CF₃ H Br CH₂CH₂CH₂SMe CF₃ H BrCH₂CH₂S(═O)Me CF₃ H Br CH(Me)CH₂S(═O)Me CF₃ H Br CH₂CH₂CH₂S(═O)Me CF₃ HBr CH₂CH₂S(O)₂Me CF₃ H Br CH(Me)CH₂S(O)₂Me CF₃ H Br CH₂CH₂CH₂S(O)₂Me CF₃H Br CH₂C(═O)N(H)CH₂CF₃ CF₃ H Br CH(Me)C(═O)N(H)CH₂CF₃ CF₃ H BrCH₂C(═O)N(H)CH₂CH₂SMe CF₃ H Br CH₂C(═O)N(H)CH₂CH₂S(O)₂Me CF₃ H Cl CH₂CH₃CF₃ H Cl CH₂—i-Pr CF₃ H Cl CH₂CH₂Cl CF₃ H Cl CH₂CH₂OH CF₃ H ClCH(Me)CH₂OH CF₃ H Cl CH₂CH(Me)OH CF₃ H Cl CH₂C(Me)₂OH CF₃ H ClCH₂CH₂CH₂OH CF₃ H Cl CH₂C(Me)₂CH₂OH CF₃ H Cl CH₂CH₂CH(Me)OH CF₃ H ClCH₂C(═O)N(H)Et CF₃ H Cl CH₂C(═O)N(H)—i-Pr CF₃ H Cl CH₂C(═O)N(H)CH₂—i-PrCF₃ H Cl CH(Me)C(═O)N(H)CH₂—i-Pr CF₃ H Cl CH₂C(═O)N(H)CH₂CH₂Cl CF₃ H ClCH(Me)C(═O)N(H)CH₂CH₂Cl CF₃ H Cl CH₂C(═O)N(H)CH₂CH₂F CF₃ H ClCH(Me)C(═O)N(H)CH₂CH₂F CF₃ H Cl CH₂CF₃ CF₃ H Cl CH₂—(2-Py) CF₃ H ClCH₂—(4-Thz) CF₃ H Cl CH₂—c-Pr CF₃ H Cl CH₂CH₂SMe CF₃ H Cl CH(Me)CH₂SMeCF₃ H Cl CH₂CH₂CH₂SMe CF₃ H Cl CH₂CH₂S(═O)Me CF₃ H Cl CH(Me)CH₂S(═O)MeCF₃ H Cl CH₂CH₂CH₂S(═O)Me CF₃ H Cl CH₂CH₂S(O)₂Me CF₃ H ClCH(Me)CH₂S(O)₂Me CF₃ H Cl CH₂CH₂CH₂S(O)₂Me CF₃ H Cl CH₂C(═O)N(H)CH₂CF₃CF₃ H Cl CH(Me)C(═O)N(H)CH₂CF₃ CF₃ H Cl CH₂C(═O)N(H)CH₂CH₂SMe CF₃ H ClCH₂C(═O)N(H)CH₂CH₂S(O)₂Me CF₃ H CF₃ CH₂CH₃ CF₃ H CF₃ CH₂—i-Pr CF₃ H CF₃CH₂CH₂Cl CF₃ H CF₃ CH₂CH₂OH CF₃ H CF₃ CH(Me)CH₂OH CF₃ H CF₃ CH₂CH(Me)OHCF₃ H CF₃ CH₂C(Me)₂OH CF₃ H CF₃ CH₂CH₂CH₂OH CF₃ H CF₃ CH₂C(Me)₂CH₂OH CF₃H CF₃ CH₂CH₂CH(Me)OH CF₃ H CF₃ CH₂C(═O)N(H)Et CF₃ H CF₃CH₂C(═O)N(H)—i-Pr CF₃ H CF₃ CH₂C(═O)N(H)CH₂—i-Pr CF₃ H CF₃CH(Me)C(═O)N(H)CH₂—i-Pr CF₃ H CF₃ CH₂C(═O)N(H)CH₂CH₂Cl CF₃ H CF₃CH(Me)C(═O)N(H)CH₂CH₂Cl CF₃ H CF₃ CH₂C(═O)N(H)CH₂CH₂F CF₃ H CF₃CH(Me)C(═O)N(H)CH₂CH₂F CF₃ H CF₃ CH₂CF₃ CF₃ H CF₃ CH₂—(2-Py) CF₃ H CF₃CH₂—(4-Thz) CF₃ H CF₃ CH₂—c-Pr CF₃ H CF₃ CH₂CH₂SMe CF₃ H CF₃CH(Me)CH₂SMe CF₃ H CF₃ CH₂CH₂CH₂SMe CF₃ H CF₃ CH₂CH₂S(═O)Me CF₃ H CF₃CH(Me)CH₂S(═O)Me CF₃ H CF₃ CH₂CH₂CH₂S(═O)Me CF₃ H CF₃ CH₂CH₂S(O)₂Me CF₃H CF₃ CH(Me)CH₂S(O)₂Me CF₃ H CF₃ CH₂CH₂CH₂S(O)₂Me CF₃ H CF₃CH₂C(═O)N(H)CH₂CF₃ CF₃ H CF₃ CH(Me)C(═O)N(H)CH₂CF₃ CF₃ H CF₃CH₂C(═O)N(H)CH₂CH₂SMe CF₃ H CF₃ CH₂C(═O)N(H)CH₂CH₂S(O)₂Me Cl Cl ClCH₂CH₃ Cl Cl Cl CH₂—i-Pr Cl Cl Cl CH₂CH₂Cl Cl Cl Cl CH₂CH₂OH Cl Cl ClCH(Me)CH₂OH Cl Cl Cl CH₂CH(Me)OH Cl Cl Cl CH₂C(Me)₂OH Cl Cl ClCH₂CH₂CH₂OH Cl Cl Cl CH₂C(Me)₂CH₂OH Cl Cl Cl CH₂CH₂CH(Me)OH Cl Cl ClCH₂C(═O)N(H)Et Cl Cl Cl CH₂C(═O)N(H)—i-Pr Cl Cl Cl CH₂C(═O)N(H)CH₂—i-PrCl Cl Cl CH(Me)C(═O)N(H)CH₂—i-Pr Cl Cl Cl CH₂C(═O)N(H)CH₂CH₂Cl Cl Cl ClCH(Me)C(═O)N(H)CH₂CH₂Cl Cl Cl Cl CH₂C(═O)N(H)CH₂CH₂F Cl Cl ClCH(Me)C(═O)N(H)CH₂CH₂F Cl Cl Cl CH₂CF₃ Cl Cl Cl CH₂—(2-Py) Cl Cl ClCH₂—(4-Thz) Cl Cl Cl CH₂—c-Pr Cl Cl Cl CH₂CH₂SMe Cl Cl Cl CH(Me)CH₂SMeCl Cl Cl CH₂CH₂CH₂SMe Cl Cl Cl CH₂CH₂S(═O)Me Cl Cl Cl CH(Me)CH₂S(═O)MeCl Cl Cl CH₂CH₂CH₂S(═O)Me Cl Cl Cl CH₂CH₂S(O)₂Me Cl Cl ClCH(Me)CH₂S(O)₂Me Cl Cl Cl CH₂CH₂CH₂S(O)₂Me Cl Cl Cl CH₂C(═O)N(H)CH₂CF₃Cl Cl Cl CH(Me)C(═O)N(H)CH₂CF₃ Cl Cl Cl CH₂C(═O)N(H)CH₂CH₂SMe Cl Cl ClCH₂C(═O)N(H)CH₂CH₂S(O)₂Me Cl F Cl CH₂CH₃ Cl F Cl CH₂—i-Pr Cl F ClCH₂CH₂Cl Cl F Cl CH₂CH₂OH Cl F Cl CH(Me)CH₂OH Cl F Cl CH₂CH(Me)OH Cl FCl CH₂C(Me)₂OH Cl F Cl CH₂CH₂CH₂OH Cl F Cl CH₂C(Me)₂CH₂OH Cl F ClCH₂CH₂CH(Me)OH Cl F Cl CH₂C(═O)N(H)Et Cl F Cl CH₂C(═O)N(H)—i-Pr Cl F ClCH₂C(═O)N(H)CH₂—i-Pr Cl F Cl CH(Me)C(═O)N(H)CH₂—i-Pr Cl F ClCH₂C(═O)N(H)CH₂CH₂Cl Cl F Cl CH(Me)C(═O)N(H)CH₂CH₂Cl Cl F ClCH₂C(═O)N(H)CH₂CH₂F Cl F Cl CH(Me)C(═O)N(H)CH₂CH₂F Cl F Cl CH₂CF₃ Cl FCl CH₂—(2-Py) Cl F Cl CH₂—(4-Thz) Cl F Cl CH₂—c-Pr Cl F Cl CH₂CH₂SMe ClF Cl CH(Me)CH₂SMe Cl F Cl CH₂CH₂CH₂SMe Cl F Cl CH₂CH₂S(═O)Me Cl F ClCH(Me)CH₂S(═O)Me Cl F Cl CH₂CH₂CH₂S(═O)Me Cl F Cl CH₂CH₂S(O)₂Me Cl F ClCH(Me)CH₂S(O)₂Me Cl F Cl CH₂CH₂CH₂S(O)₂Me Cl F Cl CH₂C(═O)N(H)CH₂CF₃ ClF Cl CH(Me)C(═O)N(H)CH₂CF₃ Cl F Cl CH₂C(═O)N(H)CH₂CH₂SMe Cl F ClCH₂C(═O)N(H)CH₂CH₂S(O)₂Me OCF₃ H Cl CH₂CH₃ OCF₃ H Cl CH₂—i-Pr OCF₃ H ClCH₂CH₂Cl OCF₃ H Cl CH₂CH₂OH OCF₃ H Cl CH(Me)CH₂OH OCF₃ H Cl CH₂CH(Me)OHOCF₃ H Cl CH₂C(Me)₂OH OCF₃ H Cl CH₂CH₂CH₂OH OCF₃ H Cl CH₂C(Me)₂CH₂OHOCF₃ H Cl CH₂CH₂CH(Me)OH OCF₃ H Cl CH₂C(═O)N(H)Et OCF₃ H ClCH₂C(═O)N(H)—i-Pr OCF₃ H Cl CH₂C(═O)N(H)CH₂—i-Pr OCF₃ H ClCH(Me)C(═O)N(H)CH₂—i-Pr OCF₃ H Cl CH₂C(═O)N(H)CH₂CH₂Cl OCF₃ H ClCH(Me)C(═O)N(H)CH₂CH₂Cl OCF₃ H Cl CH₂C(═O)N(H)CH₂CH₂F OCF₃ H ClCH(Me)C(═O)N(H)CH₂CH₂F OCF₃ H Cl CH₂CF₃ OCF₃ H Cl CH₂—(2-Py) OCF₃ H ClCH₂—(4-Thz) OCF₃ H Cl CH₂—c-Pr OCF₃ H Cl CH₂CH₂SMe OCF₃ H ClCH(Me)CH₂SMe OCF₃ H Cl CH₂CH₂CH₂SMe OCF₃ H Cl CH₂CH₂S(═O)Me OCF₃ H ClCH(Me)CH₂S(═O)Me OCF₃ H Cl CH₂CH₂CH₂S(═O)Me OCF₃ H Cl CH₂CH₂S(O)₂Me OCF₃H Cl CH(Me)CH₂S(O)₂Me OCF₃ H Cl CH₂CH₂CH₂S(O)₂Me OCF₃ H ClCH₂C(═O)N(H)CH₂CF₃ OCF₃ H Cl CH(Me)C(═O)N(H)CH₂CF₃ OCF₃ H ClCH₂C(═O)N(H)CH₂CH₂SMe OCF₃ H Cl CH₂C(═O)N(H)CH₂CH₂S(O)₂Me

TABLE 11

R^(2a) R^(2b) R^(2c) R⁵ Cl H Cl CH₃ Cl H Cl CH₂CH₃ Cl H Cl CH₂—i-Pr Cl HCl n-Pr Cl H Cl i-Pr Cl H Cl s-Bu Cl H Cl t-Bu Cl H Cl (CH₂)₅CH₃ Cl H ClCH₂Ph Br H Br CH₃ Br H Br CH₂CH₃ Br H Br CH₂—i-Pr Br H Br n-Pr Br H Bri-Pr Br H Br s-Bu Br H Br t-Bu Br H Br (CH₂)₅CH₃ Br H Br CH₂Ph CF₃ H HCH₃ CF₃ H H CH₂CH₃ CF₃ H H CH₂—i-Pr CF₃ H H n-Pr CF₃ H H i-Pr CF₃ H Hs-Bu CF₃ H H t-Bu CF₃ H H (CH₂)₅CH₃ CF₃ H H CH₂Ph CF₃ H F CH₃ CF₃ H FCH₂CH₃ CF₃ H F CH₂—i-Pr CF₃ H F n-Pr CF₃ H F i-Pr CF₃ H F s-Bu CF₃ H Ft-Bu CF₃ H F (CH₂)₅CH₃ CF₃ H F CH₂Ph CF₃ H Br CH₃ CF₃ H Br CH₂CH₃ CF₃ HBr CH₂—i-Pr CF₃ H Br n-Pr CF₃ H Br i-Pr CF₃ H Br s-Bu CF₃ H Br t-Bu CF₃H Br (CH₂)₅CH₃ CF₃ H Br CH₂Ph CF₃ H Cl CH₃ CF₃ H Cl CH₂CH₃ CF₃ H ClCH₂—i-Pr CF₃ H Cl n-Pr CF₃ H Cl i-Pr CF₃ H Cl s-Bu CF₃ H Cl t-Bu CF₃ HCl (CH₂)₅CH₃ CF₃ H Cl CH₂Ph CF₃ H CF₃ CH₃ CF₃ H CF₃ CH₂CH₃ CF₃ H CF₃CH₂—i-Pr CF₃ H CF₃ n-Pr CF₃ H CF₃ i-Pr CF₃ H CF₃ s-Bu CF₃ H CF₃ t-Bu CF₃H CF₃ (CH₂)₅CH₃ CF₃ H CF₃ CH₂Ph Cl Cl Cl CH₃ Cl Cl Cl CH₂CH₃ Cl Cl ClCH₂—i-Pr Cl Cl Cl n-Pr Cl Cl Cl i-Pr Cl Cl Cl s-Bu Cl Cl Cl t-Bu Cl ClCl (CH₂)₅CH₃ Cl Cl Cl CH₂Ph Cl F Cl CH₃ Cl F Cl CH₂CH₃ Cl F Cl CH₂—i-PrCl F Cl n-Pr Cl F Cl i-Pr Cl F Cl s-Bu Cl F Cl t-Bu Cl F Cl (CH₂)₅CH₃ ClF Cl CH₂Ph OCF₃ H Cl CH₃ OCF₃ H Cl CH₂CH₃ OCF₃ H Cl CH₂—i-Pr OCF₃ H Cln-Pr OCF₃ H Cl i-Pr OCF₃ H Cl s-Bu OCF₃ H Cl t-Bu OCF₃ H Cl (CH₂)₅CH₃OCF₃ H Cl CH₂Ph

TABLE 12

R^(2a) R^(2b) R^(2c) R³ Cl H Cl Cl Cl H Cl Br Cl H Cl I Cl H Cl OH Cl HCl OMe Cl H Cl OS(O)₂CF₃ Cl H Cl nitro Cl H Cl NH₂ Cl H Cl cyano Cl H ClMe Cl H Cl CH₂Cl Cl H Cl CH₂Br Cl H Cl CH₂OH Cl H Cl CH₂OC(O)Me Cl H ClCO₂H Cl H Cl n-Pr Br H Br Cl Br H Br Br Br H Br I Br H Br OH Br H Br OMeBr H Br OS(O)₂CF₃ Br H Br nitro Br H Br NH₂ Br H Br cyano Br H Br Me BrH Br CH₂Cl Br H Br CH₂Br Br H Br CH₂OH Br H Br CH₂OC(O)Me Br H Br CO₂HBr H Br n-Pr CF₃ H H Cl CF₃ H H Br CF₃ H H I CF₃ H H OH CF₃ H H OMe CF₃H H OS(O)₂CF₃ CF₃ H H nitro CF₃ H H NH₂ CF₃ H H cyano CF₃ H H Me CF₃ H HCH₂Cl CF₃ H H CH₂Br CF₃ H H CH₂OH CF₃ H H CH₂OC(O)Me CF₃ H H CO₂H CF₃ HH n-Pr CF₃ H F Cl CF₃ H F Br CF₃ H F I CF₃ H F OH CF₃ H F OMe CF₃ H FOS(O)₂CF₃ CF₃ H F nitro CF₃ H F NH₂ CF₃ H F cyano CF₃ H F Me CF₃ H FCH₂Cl CF₃ H F CH₂Br CF₃ H F CH₂OH CF₃ H F CH₂OC(O)Me CF₃ H F CO₂H CF₃ HF n-Pr CF₃ H Br Cl CF₃ H Br Br CF₃ H Br I CF₃ H Br OH CF₃ H Br OMe CF₃ HBr OS(O)₂CF₃ CF₃ H Br nitro CF₃ H Br NH₂ CF₃ H Br cyano CF₃ H Br Me CF₃H Br CH₂Cl CF₃ H Br CH₂Br CF₃ H Br CH₂OH CF₃ H Br CH₂OC(O)Me CF₃ H BrCO₂H CF₃ H Br n-Pr CF₃ H Cl Cl CF₃ H Cl Br CF₃ H Cl I CF₃ H Cl OH CF₃ HCl OMe CF₃ H Cl OS(O)₂CF₃ CF₃ H Cl nitro CF₃ H Cl NH₂ CF₃ H Cl cyano CF₃H Cl Me CF₃ H Cl CH₂Cl CF₃ H Cl CH₂Br CF₃ H Cl CH₂OH CF₃ H Cl CH₂OC(O)MeCF₃ H Cl CO₂H CF₃ H Cl n-Pr CF₃ H CF₃ Cl CF₃ H CF₃ Br CF₃ H CF₃ I CF₃ HCF₃ OH CF₃ H CF₃ OMe CF₃ H CF₃ OS(O)₂CF₃ CF₃ H CF₃ nitro CF₃ H CF₃ NH₂CF₃ H CF₃ cyano CF₃ H CF₃ Me CF₃ H CF₃ CH₂Cl CF₃ H CF₃ CH₂Br CF₃ H CF₃CH₂OH CF₃ H CF₃ CH₂OC(O)Me CF₃ H CF₃ CO₂H CF₃ H CF₃ n-Pr Cl Cl Cl Cl ClCl Cl Br Cl Cl Cl I Cl Cl Cl OH Cl Cl Cl OMe Cl Cl Cl OS(O)₂CF₃ Cl Cl Clnitro Cl Cl Cl NH₂ Cl Cl Cl cyano Cl Cl Cl Me Cl Cl Cl CH₂Cl Cl Cl ClCH₂Br Cl Cl Cl CH₂OH Cl Cl Cl CH₂OC(O)Me Cl Cl Cl CO₂H Cl Cl Cl n-Pr ClF Cl Cl Cl F Cl Br Cl F Cl I Cl F Cl OH Cl F Cl OMe Cl F Cl OS(O)₂CF₃ ClF Cl nitro Cl F Cl NH₂ Cl F Cl cyano Cl F Cl Me Cl F Cl CH₂Cl Cl F ClCH₂Br Cl F Cl CH₂OH Cl F Cl CH₂OC(O)Me Cl F Cl CO₂H Cl F Cl n-Pr OCF₃ HCl Cl OCF₃ H Cl Br OCF₃ H Cl I OCF₃ H Cl OH OCF₃ H Cl OMe OCF₃ H ClOS(O)₂CF₃ OCF₃ H Cl nitro OCF₃ H Cl NH₂ OCF₃ H Cl cyano OCF₃ H Cl MeOCF₃ H Cl CH₂Cl OCF₃ H Cl CH₂Br OCF₃ H Cl CH₂OH OCF₃ H Cl CH₂OC(O)MeOCF₃ H Cl CO₂H OCF₃ H Cl n-Pr

Tables 13-14 relate to the method of Scheme 2 converting compounds ofFormula 5 to Grignard reagents, which are contacted with compounds ofFormula 6 to prepare compounds of Formula 2. X¹ can be the same as ordifferent than X, as explained in the description of the method ofScheme 2.

In the example transformations embodied in these tables the solventcomprises tetrahydrofuran.

TABLE 13

R^(2a) R^(2b) R^(2c) X Y Cl H Cl I OMe Cl H Cl I OEt Cl H Cl I O—i-Pr ClH Cl I O(CH₂)₄CH₃ Cl H Cl I N(CH₃)₂ Cl H Cl I N(CH₃)(CH₂CH₃) Cl H Cl INCH₂CH₂OCH₂CH₂ Cl H Cl Br OMe Cl H Cl Br OEt Cl H Cl Br O—i-Pr Cl H ClBr O(CH₂)₄CH₃ Cl H Cl Br N(CH₃)₂ Cl H Cl Br N(CH₃)(CH₂CH₃) Cl H Cl BrNCH₂CH₂OCH₂CH₂ CF₃ H Br I OMe CF₃ H Br I OEt CF₃ H Br I O—i-Pr CF₃ HBr I O(CH₂)₄CH₃ CF₃ H Br I N(CH₃)₂ CF₃ H Br I N(CH₃)(CH₂CH₃) CF₃ H Br INCH₂CH₂OCH₂CH₂ CF₃ H H I OMe CF₃ H H I OEt CF₃ H H I O—i-Pr CF₃ H H IO(CH₂)₄CH₃ CF₃ H H I N(CH₃)₂ CF₃ H H I N(CH₃)(CH₂CH₃) CF₃ H H INCH₂CH₂OCH₂CH₂ CF₃ H H Br OMe CF₃ H H Br OEt CF₃ H H Br O—i-Pr CF₃ H HBr O(CH₂)₄CH₃ CF₃ H H Br N(CH₃)₂ CF₃ H H Br N(CH₃)(CH₂CH₃) CF₃ H H BrNCH₂CH₂OCH₂CH₂ CF₃ H H Cl OMe CF₃ H H Cl OEt CF₃ H H Cl O—i-Pr CF₃ H HCl O(CH₂)₄CH₃ CF₃ H H Cl N(CH₃)₂ CF₃ H H Cl N(CH₃)(CH₂CH₃) CF₃ H H ClNCH₂CH₂OCH₂CH₂ CF₃ H F I OMe CF₃ H F I OEt CF₃ H F I O—i-Pr CF₃ H F IO(CH₂)₄CH₃ CF₃ H F I N(CH₃)₂ CF₃ H F I N(CH₃)(CH₂CH₃) CF₃ H F INCH₂CH₂OCH₂CH₂ CF₃ H F Br OMe CF₃ H F Br OEt CF₃ H F Br O—i-Pr CF₃ H FBr O(CH₂)₄CH₃ CF₃ H F Br N(CH₃)₂ CF₃ H F Br N(CH₃)(CH₂CH₃) CF₃ H F BrNCH₂CH₂OCH₂CH₂ CF₃ H F Cl OMe CF₃ H F Cl OEt CF₃ H F Cl O—i-Pr CF₃ H FCl O(CH₂)₄CH₃ CF₃ H F Cl N(CH₃)₂ CF₃ H F Cl N(CH₃)(CH₂CH₃) CF₃ H F ClNCH₂CH₂OCH₂CH₂ CF₃ H Cl I OMe CF₃ H Cl I OEt CF₃ H Cl I O—i-Pr CF₃ HCl I O(CH₂)₄CH₃ CF₃ H Cl I N(CH₃)₂ CF₃ H Cl I N(CH₃)(CH₂CH₃) CF₃ H Cl INCH₂CH₂OCH₂CH₂ CF₃ H Cl Br OMe CF₃ H Cl Br OEt CF₃ H Cl Br O—i-Pr CF₃H Cl Br O(CH₂)₄CH₃ CF₃ H Cl Br N(CH₃)₂ CF₃ H Cl Br N(CH₃)(CH₂CH₃) CF₃ HCl Br NCH₂CH₂OCH₂CH₂ CF₃ H CF₃ I OMe CF₃ H CF₃ I OEt CF₃ H CF₃ IO—i-Pr CF₃ H CF₃ I O(CH₂)₄CH₃ CF₃ H CF₃ I N(CH₃)₂ CF₃ H CF₃ IN(CH₃)(CH₂CH₃) CF₃ H CF₃ I NCH₂CH₂OCH₂CH₂ CF₃ H CF₃ Br OMe CF₃ H CF₃Br OEt CF₃ H CF₃ Br O—i-Pr CF₃ H CF₃ Br O(CH₂)₄CH₃ CF₃ H CF₃ Br N(CH₃)₂CF₃ H CF₃ Br N(CH₃)(CH₂CH₃) CF₃ H CF₃ Br NCH₂CH₂OCH₂CH₂ CF₃ H CF₃ ClOMe CF₃ H CF₃ Cl OEt CF₃ H CF₃ Cl O—i-Pr CF₃ H CF₃ Cl O(CH₂)₄CH₃ CF₃ HCF₃ Cl N(CH₃)₂ CF₃ H CF₃ Cl N(CH₃)(CH₂CH₃) CF₃ H CF₃ Cl NCH₂CH₂OCH₂CH₂Cl Cl Cl I OMe Cl Cl Cl I OEt Cl Cl Cl I O—i-Pr Cl Cl Cl I O(CH₂)₄CH₃ ClCl Cl I N(CH₃)₂ Cl Cl Cl I N(CH₃)(CH₂CH₃) Cl Cl Cl I NCH₂CH₂OCH₂CH₂ ClCl Cl Br OMe Cl Cl Cl Br OEt Cl Cl Cl Br O—i-Pr Cl Cl Cl Br O(CH₂)₄CH₃Cl Cl Cl Br N(CH₃)₂ Cl Cl Cl Br N(CH₃)(CH₂CH₃) Cl Cl Cl BrNCH₂CH₂OCH₂CH₂ Cl F Cl I OMe Cl F Cl I OEt Cl F Cl I O—i-Pr Cl F Cl IO(CH₂)₄CH₃ Cl F Cl I N(CH₃)₂ Cl F Cl I N(CH₃)(CH₂CH₃) Cl F Cl INCH₂CH₂OCH₂CH₂ Cl F Cl Br OMe Cl F Cl Br OEt Cl F Cl Br O—i-Pr Cl F ClBr O(CH₂)₄CH₃ Cl F Cl Br N(CH₃)₂ Cl F Cl Br N(CH₃)(CH₂CH₃) Cl F Cl BrNCH₂CH₂OCH₂CH₂

TABLE 14

R^(2a) R^(2b) R^(2c) X Y Cl H Cl I OMe Cl H Cl I OEt Cl H Cl I O—i-Pr ClH Cl I O(CH₂)₄CH₃ Cl H Cl I N(CH₃)₂ Cl H Cl I N(CH₃)(CH₂CH₃) Cl H Cl INCH₂CH₂OCH₂CH₂ Cl H Cl Br OMe Cl H Cl Br OEt Cl H Cl Br O—i-Pr Cl H ClBr O(CH₂)₄CH₃ Cl H Cl Br N(CH₃)₂ Cl H Cl Br N(CH₃)(CH₂CH₃) Cl H Cl BrNCH₂CH₂OCH₂CH₂ CF₃ H Br I OMe CF₃ H Br I OEt CF₃ H Br I O—i-Pr CF₃ HBr I O(CH₂)₄CH₃ CF₃ H Br I N(CH₃)₂ CF₃ H Br I N(CH₃)(CH₂CH₃) CF₃ H Br INCH₂CH₂OCH₂CH₂ CF₃ H H I OMe CF₃ H H I OEt CF₃ H H I O—i-Pr CF₃ H H IO(CH₂)₄CH₃ CF₃ H H I N(CH₃)₂ CF₃ H H I N(CH₃)(CH₂CH₃) CF₃ H H INCH₂CH₂OCH₂CH₂ CF₃ H H Br OMe CF₃ H H Br OEt CF₃ H H Br O—i-Pr CF₃ H HBr O(CH₂)₄CH₃ CF₃ H H Br N(CH₃)₂ CF₃ H H Br N(CH₃)(CH₂CH₃) CF₃ H H BrNCH₂CH₂OCH₂CH₂ CF₃ H H Cl OMe CF₃ H H Cl OEt CF₃ H H Cl O—i-Pr CF₃ H HCl O(CH₂)₄CH₃ CF₃ H H Cl N(CH₃)₂ CF₃ H H Cl N(CH₃)(CH₂CH₃) CF₃ H H ClNCH₂CH₂OCH₂CH₂ CF₃ H F I OMe CF₃ H F I OEt CF₃ H F I O—i-Pr CF₃ H F IO(CH₂)₄CH₃ CF₃ H F I N(CH₃)₂ CF₃ H F I N(CH₃)(CH₂CH₃) CF₃ H F INCH₂CH₂OCH₂CH₂ CF₃ H F Br OMe CF₃ H F Br OEt CF₃ H F Br O—i-Pr CF₃ H FBr O(CH₂)₄CH₃ CF₃ H F Br N(CH₃)₂ CF₃ H F Br N(CH₃)(CH₂CH₃) CF₃ H F BrNCH₂CH₂OCH₂CH₂ CF₃ H F Cl OMe CF₃ H F Cl OEt CF₃ H F Cl O—i-Pr CF₃ H FCl O(CH₂)₄CH₃ CF₃ H F Cl N(CH₃)₂ CF₃ H F Cl N(CH₃)(CH₂CH₃) CF₃ H F ClNCH₂CH₂OCH₂CH₂ CF₃ H Cl I OMe CF₃ H Cl I OEt CF₃ H Cl I O—i-Pr CF₃ HCl I O(CH₂)₄CH₃ CF₃ H Cl I N(CH₃)₂ CF₃ H Cl I N(CH₃)(CH₂CH₃) CF₃ H Cl INCH₂CH₂OCH₂CH₂ CF₃ H Cl Br OMe CF₃ H Cl Br OEt CF₃ H Cl Br O—i-Pr CF₃H Cl Br O(CH₂)₄CH₃ CF₃ H Cl Br N(CH₃)₂ CF₃ H Cl Br N(CH₃)(CH₂CH₃) CF₃ HCl Br NCH₂CH₂OCH₂CH₂ CF₃ H CF₃ I OMe CF₃ H CF₃ I OEt CF₃ H CF₃ IO—i-Pr CF₃ H CF₃ I O(CH₂)₄CH₃ CF₃ H CF₃ I N(CH₃)₂ CF₃ H CF₃ IN(CH₃)(CH₂CH₃) CF₃ H CF₃ I NCH₂CH₂OCH₂CH₂ CF₃ H CF₃ Br OMe CF₃ H CF₃Br OEt CF₃ H CF₃ Br O—i-Pr CF₃ H CF₃ Br O(CH₂)₄CH₃ CF₃ H CF₃ Br N(CH₃)₂CF₃ H CF₃ Br N(CH₃)(CH₂CH₃) CF₃ H CF₃ Br NCH₂CH₂OCH₂CH₂ CF₃ H CF₃ ClOMe CF₃ H CF₃ Cl OEt CF₃ H CF₃ Cl O—i-Pr CF₃ H CF₃ Cl O(CH₂)₄CH₃ CF₃ HCF₃ Cl N(CH₃)₂ CF₃ H CF₃ Cl N(CH₃)(CH₂CH₃) CF₃ H CF₃ Cl NCH₂CH₂OCH₂CH₂Cl Cl Cl I OMe Cl Cl Cl I OEt Cl Cl Cl I O—i-Pr Cl Cl Cl I O(CH₂)₄CH₃ ClCl Cl I N(CH₃)₂ Cl Cl Cl I N(CH₃)(CH₂CH₃) Cl Cl Cl I NCH₂CH₂OCH₂CH₂ ClCl Cl Br OMe Cl Cl Cl Br OEt Cl Cl Cl Br O—i-Pr Cl Cl Cl Br O(CH₂)₄CH₃Cl Cl Cl Br N(CH₃)₂ Cl Cl Cl Br N(CH₃)(CH₂CH₃) Cl Cl Cl BrNCH₂CH₂OCH₂CH₂ Cl F Cl I OMe Cl F Cl I OEt Cl F Cl I O—i-Pr Cl F Cl IO(CH₂)₄CH₃ Cl F Cl I N(CH₃)₂ Cl F Cl I N(CH₃)(CH₂CH₃) Cl F Cl INCH₂CH₂OCH₂CH₂ Cl F Cl Br OMe Cl F Cl Br OEt Cl F Cl Br O—i-Pr Cl F ClBr O(CH₂)₄CH₃ Cl F Cl Br N(CH₃)₂ Cl F Cl Br N(CH₃)(CH₂CH₃) Cl F Cl BrNCH₂CH₂OCH₂CH₂

The following compounds of Formula 3 defined in Table 15 are ofparticular note as intermediates for preparing the correspondingcompounds of Formula 1 as shown in Schemes 1, 1a and 1b by theprocedures described herein together with methods known in the art.

TABLE 15

R⁵ CH₂CH₃ CH₂—i-Pr CH₂CH₂Cl CH₂CH₂OH CH(Me)CH₂OH CH₂CH(Me)OH CH₂C(Me)₂OHCH₂CH₂CH₂OH CH₂C(Me)₂CH₂OH CH₂CH₂CH(Me)OH CH₂C(O)N(H)Et CH₂C(O)N(H)—i-PrCH₂C(O)N(H)CH₂—i-Pr CH(Me)C(O)N(H)CH₂—i-Pr CH₂C(O)N(H)CH₂CH₂ClCH(Me)C(O)N(H)CH₂CH₂Cl CH₂C(O)N(H)CH₂CH₂F CH(Me)C(O)N(H)CH₂CH₂F CH₂CF₃CH₂—(2-Py) CH₂—(4-Thz) CH₂—c-Pr CH₂CH₂SMe CH(Me)CH₂SMe CH₂CH₂CH₂SMeCH₂CH₂S(O)Me CH(Me)CH₂S(O)Me CH₂CH₂CH₂S(O)Me CH₂CH₂SO₂Me CH(Me)CH₂SO₂MeCH₂CH₂CH₂SO₂Me CH₂C(O)N(H)CH₂CF₃ CH(Me)C(O)N(H)CH₂CF₃CH₂C(O)N(H)CH₂CH₂SMe CH₂C(O)N(H)CH₂CH₂SO₂Me CH₂CH₂SEt CH₂CH₂S(n-Pr)CH₂CH₂CH₂SEt CH₂CH₂S(O)Et CH₂CH₂S(O)(n-Pr) CH₂CH₂CH₂S(O)Et CH₂CH₂SO₂EtCH₂CH₂SO₂(n-Pr) CH₂CH₂CH₂SO₂Et CH₂C(O)NH(Me) CH₂C(O)NH(n-Pr)CH₂C(O)NH(s-Bu) CH₂C(O)NMe₂ CH₂C(O)NMe(Et) CH(Me)C(O)NH(Me)CH(Me)C(O)NH(Et) CH(Me)C(O)NH(n-Pr) CH(Me)C(O)NH(i-Pr)CH(Me)C(O)NH(s-Bu) CH₂C(O)NHCH₂CHF₂ CH₂C(O)NHCH₂CH₂CF₃CH₂C(O)NHCH(Me)CF₃ CH₂C(O)NHCH₂CH(Me)CF₃ CH(Me)C(O)NHCH₂CHF₂CH(Me)C(O)NHCH₂CH₂CF₃ CH(Me)C(O)NHCH(Me)CF₃ CH(Me)C(O)NHCH₂CH(Me)CF₃

1. A method for preparing a compound of Formula 1

wherein Z is optionally substituted phenyl; and Q is phenyl or1-naphthalenyl, each optionally substituted; comprising distilling waterfrom a mixture comprising a compound of Formula 2

a compound of Formula 3

a base comprising at least one compound selected from the groupconsisting of alkaline earth metal hydroxides of Formula 4M(OH)₂   4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula4a(M¹)₂CO₃   4a wherein M¹ is Li, Na or K,1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene,and an aprotic solvent capable of forming a low-boiling azeotrope withwater. 2-5. (canceled)
 6. The method of claim 1 wherein the basecomprises an alkali metal carbonate of Formula 4a.
 7. The method ofclaim 6 wherein M¹ is K.
 8. (canceled)
 9. The method of claim 6, whereinthe aprotic solvent capable of forming a low-boiling azeotrope withwater comprises acetonitrile.
 10. The method of claim 1 wherein Z isphenyl optionally substituted with up to 5 substituents independentlyselected from R²; Q is phenyl or 1-naphthalenyl, each optionallysubstituted with up to four substituents independently selected from R³;each R² is independently halogen, C₁-C₆ alkyl, C₁-C₆ haloalkyl, C₁-C₆alkoxy, C₁-C₆ haloalkoxy, C₁-C₆ alkylthio, C₁-C₆ haloalkylthio, C₁-C₆alkylamino, C₂-C₆ dialkylamino, —CN or —NO₂; each R³ is independentlyhalogen, C₁-C₆ alkyl, C₁-C₆ haloalkyl, C₂-C₆ alkenyl, C₂-C₆ haloalkenyl,C₂-C₆ alkynyl, C₃-C₆ haloalkynyl, C₃-C₆ cycloalkyl, C₃-C₆halocycloalkyl, C₁-C₆ alkoxy, C₁-C₆ haloalkoxy, C₁-C₆ alkylthio, C₂-C₇alkylcarbonyl, C₂-C₇ haloalkylcarbonyl, C₁-C₆ haloalkylthio, C₁-C₆alkylsulfinyl, C₁-C₆ haloalkylsulfinyl, C₁-C₆ alkylsulfonyl, C₁-C₆haloalkylsulfonyl, —N(R⁴)R⁵, —C(═W)N(R⁴)R⁵, —C(═W)OR⁵, —CN, —OR¹¹ or—NO₂; or a phenyl ring or a 5- or 6-membered saturated or unsaturatedheterocyclic ring, each ring optionally substituted with one or moresubstituents independently selected from halogen, C₁-C₆ alkyl, C₁-C₆haloalkyl, C₃-C₆ cycloalkyl, C₃-C₆ halocycloalkyl, C₁-C₆ alkoxy, C₁-C₆haloalkoxy, C₁-C₆ alkylthio, C₁-C₆ haloalkylthio, C₁-C₆ alkylsulfinyl,C₁-C₆ haloalkylsulfinyl, C₁-C₆ alkylsulfonyl, C₁-C₆ haloalkylsulfonyl,—CN, —NO₂, —N(R⁴)R⁵, —C(═W)N(R⁴)R⁵, —C(═O)OR⁵ and R⁷; each R⁴ isindependently H, C₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, C₃-C₆cycloalkyl, C₄-C₇ alkylcycloalkyl, C₄-C₇ cycloalkylalkyl, C₂-C₇alkylcarbonyl or C₂-C₇ alkoxycarbonyl; each R⁵ is independently H; orC₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, C₃-C₆ cycloalkyl, C₄-C₇alkylcycloalkyl or C₄-C₇ cycloalkylalkyl, each optionally substitutedwith one or more substituents independently selected from R⁶; each R⁶ isindependently halogen, C₁-C₆ alkyl, C₁-C₆ alkoxy, C₁-C₆ alkylthio, C₁-C₆alkylsulfinyl, C₁-C₆ alkylsulfonyl, C₁-C₆ alkylamino, C₂-C₈dialkylamino, C₃-C₆ cycloalkylamino, C₂-C₇ alkylcarbonyl, C₂-C₇alkoxycarbonyl, C₂-C₇ alkylaminocarbonyl, C₃-C₉ dialkylaminocarbonyl,C₂-C₇ haloalkylcarbonyl, C₂-C₇ haloalkoxycarbonyl, C₂-C₇haloalkylaminocarbonyl, C₃-C₉ halodialkylaminocarbonyl, —OH, —NH₂, —CNor —NO₂; or Q¹; each R⁷ is independently a phenyl ring or a pyridinylring, each ring optionally substituted with one or more substituentsindependently selected from R⁸; each R⁸ is independently halogen, C₁-C₆alkyl, C₁-C₆ haloalkyl, C₁-C₆ alkoxy, C₁-C₆ haloalkoxy, C₁-C₆ alkylthio,C₁-C₆ haloalkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆ haloalkylsulfinyl, C₁-C₆alkylsulfonyl, C₁-C₆ haloalkylsulfonyl, C₁-C₆ alkylamino, C₂-C₆dialkylamino, C₂-C₄ alkylcarbonyl, C₂-C₄ alkoxycarbonyl, C₂-C₇alkylaminocarbonyl, C₃-C₇ dialkylaminocarbonyl, —OH, —NH₂, —C(═O)OH, —CNor —NO₂; each Q¹ is independently a phenyl ring or a 5- or 6-memberedsaturated or unsaturated heterocyclic ring, each ring optionallysubstituted with one or more substituents independently selected fromhalogen, C₁-C₆ alkyl, C₁-C₆ haloalkyl, C₃-C₆ cycloalkyl, C₃-C₆halocycloalkyl, C₁-C₆ alkoxy, C₁-C₆ haloalkoxy, C₁-C₆ alkylthio, C₁-C₆haloalkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆ haloalkylsulfinyl, C₁-C₆alkylsulfonyl, C₁-C₆ haloalkylsulfonyl, C₁-C₆ alkylamino, C₂-C₆dialkylamino, —CN, —NO₂, —C(═W)N(R⁹)R¹⁰ and —C(═O)OR¹⁰; each R⁹ isindependently H, C₁-C₆ alkyl, C₁-C₆ haloalkyl, C₂-C₆ alkenyl, C₂-C₆alkynyl, C₃-C₆ cycloalkyl, C₄-C₇ alkylcycloalkyl, C₄-C₇ cycloalkylalkyl,C₂-C₇ alkylcarbonyl or C₂-C₇ alkoxycarbonyl; each R¹⁰ is independentlyH; or C₁-C₆ alkyl, C₁-C₆ haloalkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, C₃-C₆cycloalkyl, C₄-C₇ alkylcycloalkyl or C₄-C₇ cycloalkylalkyl; each R¹¹ isindependently H; or C₂-C₆ alkenyl, C₂-C₆ alkynyl, C₃-C₆ cycloalkyl,C₄-C₇ alkylcycloalkyl, C₄-C₇ cycloalkylalkyl, C₂-C₇ alkylcarbonyl, C₂-C₇alkoxycarbonyl, C₁-C₆ alkylsulfonyl or C₁-C₆ haloalkylsulfonyl; and eachW is independently O or S.
 11. The method of claim 10 wherein Z is

Q is

R^(2a) is halogen, C₁-C₂ haloalkyl or C₁-C₂ haloalkoxy; R^(2b) is H,halogen or cyano; R^(2c) is H, halogen or CF₃; R³ is C(O)N(R⁴)R⁵ orC(O)OR^(5a); R⁴ is H, C₂-C₇ alkylcarbonyl or C₂-C₇ alkoxycarbonyl; andR⁵ is C₁-C₆ alkyl or C₁-C₆ haloalkyl, each substituted with onesubstituent independently selected from hydroxy, C₁-C₆ alkoxy, C₁-C₆alkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆ alkylsulfonyl, C₂-C₇alkylaminocarbonyl, C₃-C₉ dialkylaminocarbonyl, C₂-C₇haloalkylaminocarbonyl and C₃-C₉ halodialkylaminocarbonyl; and R^(5a) isC₁-C₆ alkyl, C₂-C₆ alkenyl or C₂-C₆ alkynyl, each optionally substitutedwith one or more substituents independently selected from halogen, C₁-C₂alkoxy and phenyl optionally substituted with up to 5 substituentsselected from halogen and C₁-C₃ alkyl.
 12. The method of claim 1 whereinZ is phenyl optionally substituted with up to 5 substituentsindependently selected from R²; and each R² is independently F, Cl, Br,C₁-C₆ alkyl, C₁-C₆ fluoroalkyl, C₁-C₆ alkoxy, C₁-C₆ fluoroalkoxy, C₁-C₆alkylthio or C₁-C₆ fluoroalkylthio; further comprising preparing thecompound of Formula 2 by (1) forming a reaction mixture comprising aGrignard reagent derived from a compound of Formula 5Z—X   5 wherein X is Cl, Br or I, by contacting the compound of Formula5 with (a) magnesium metal, or (b) an alkylmagnesium halide in thepresence of an ethereal solvent; and then (2) contacting the reactionmixture with a compound of Formula 6

wherein Y is OR¹¹ or NR¹²R¹³; R¹¹ is C₁-C₅ alkyl; and R¹² and R¹³ areindependently C₁-C₂ alkyl; or R¹² and R¹³ are taken together as—CH₂CH₂OCH₂CH₂—.
 13. The method of claim 12 wherein Z is

R^(2a) is F, Cl, Br, C₁-C₂ fluoroalkyl or C₁-C₂ fluoroalkoxy; R^(2b) isH, F, Cl or Br; and R^(2c) is H, F, Cl, Br or CF₃. 14-22. (canceled) 23.The method of claim 7, wherein the aprotic solvent capable of forming alow-boiling azeotrope with water comprises acetonitrile.
 24. The methodof claim 10 wherein the base comprises an alkali metal carbonate ofFormula 4a.
 25. The method of claim 24 wherein M¹ is K.
 26. The methodof claim 11 wherein the base comprises an alkali metal carbonate ofFormula 4a.
 27. The method of claim 26 wherein M¹ is K.
 28. The methodof claim 12 wherein the base comprises an alkali metal carbonate ofFormula 4a.
 29. The method of claim 28 wherein M¹ is K.
 30. The methodof claim 13 wherein the base comprises an alkali metal carbonate ofFormula 4a.
 31. The method of claim 30 wherein M¹ is K.